Vector Core

矢量核心

• 批准号: 8375800
• 负责人: BARRY J BYRNE
• 金额: $ 18.57万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8375800
• 关键词: Baculoviruses; Clinical Trials; Cystic Fibrosis; Genes; Methods; Primates; Production; Program Research Project Grants; Recombinants; Research; System; Testing; Toxicology; Viral Vector; pre-clinical; programs; vector

The Vector Core's primary function is to supply recombinant Adeno-associated (rAAV) viral vector stocks that are used by all subprojects of this program. In addition to supplying research grade rAAV, the Core will develop a modified scalable baculovirus production system for rAAV1 that will be used for the anticipated clinical trial described in Project 1. Finally, the Core will supply GLP grade rAAV1 for preclinical toxicology studies and primate studies for Project 1.

向量核心的主要功能是提供重组腺相关（RAAV）病毒载体库存 该程序的所有子标题都使用。除了提供研究级RAAV外，核心还将 为RAAV1开发一个可改进的可伸缩杆病毒生产系统，该系统将用于预期 项目1中描述的临床试验。最后，核心将为临床前毒理学提供GLP级RAAV1 项目1的研究和灵长类动物研究。