X-ray/Fluorescence Molecular and Diffuse Optical Tomography of Glioma
胶质瘤的 X 射线/荧光分子和漫反射光学断层扫描
基本信息
- 批准号:8292191
- 负责人:
- 金额:$ 18.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2012-10-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAffectAlgorithmsAnimalsAppointmentAreaBackBedsBiochemistryBiologicalBiomedical EngineeringBiometryBrainBrain NeoplasmsCancer CenterCareer Transition AwardCervicalClinicalClinical ResearchClinical TrialsCollectionDataDecision MakingDetectionDevelopmentDiffuseDisease ProgressionDisease regressionElementary ParticlesEngineeringEventEvolutionExcisionFluorescenceFrequenciesFundingGermanyGliomaGoalsGraduate EducationGroup MeetingsGrowth Factor ReceptorsHemoglobinHumanHybridsImageImaging DeviceImaging TechniquesKnowledgeLabelLeadLeftLightMalignant GliomaMalignant NeoplasmsMammary NeoplasmsMapsMeasurementMedicalMedical ImagingMedical centerMetabolismMethodsMicroscopeModelingModificationMolecularMonitorMorphologic artifactsMusNeurosurgeonNorris Cotton Cancer CenterOperative Surgical ProceduresOptical TomographyOpticsOrganismOutcomePathologicPathologic ProcessesPatientsPhotonsPhysicsPhysiologic pulsePhysiologicalPrincipal InvestigatorProcessRadiology SpecialtyResearchResearch PersonnelResearch Project GrantsResourcesRoentgen RaysSchoolsScienceScientistSignal TransductionSourceStructureSurfaceSystemTechniquesTechnologyTestingThree-Dimensional ImageTimeTissue EngineeringTissuesTrainingVariantWidthWorkX-Ray Computed Tomographybasecareerclinical applicationcollegecraniumdata acquisitiondesigndetectordiffuse optical tomographyexperiencefluorescence imagingfluorophoreimage reconstructionimaging modalityimprovedin vivoinsightinstrumentinterestlectureslight emissionmedical schoolsmicrosystemsmolecular imagingneoplastic cellnon-invasive monitornoveloncologyoptical fiberoptical imagingpre-clinicalprogramsreceptor expressionsymposiumtheoriestherapy designtomographytumortumor growthtumor progression
项目摘要
Program Director/Principal Investigator (Last, First, Middle): Leblond, Frederic
PROJECT SUMMARY (Seeinstructions):
Before changing fields to optical imaging, the candidate has worked doing research in elementary
particle physics and general relativity in the area of superstring theory. The long term career goal of the
candidate is to become an independent researcher who has a unique set of knowledge and breadth of
experience in numerical and analytical modeling as well as in biomedical engineering and medical sciences
in order to develop new medical imaging tools and applications contributing to understanding tumor
management. The immediate goal of the candidate is to upgrade an existing hybrid x-ray/near-infrared
tomography system for pre-clinical time-domain measurements, making it optimal for imaging glioma tumors
grown in mice. The main research objective of this proposal is to develop new data acquisition methods and
algorithms to create tomography images that provide synergistic anatomical and functional information
pertaining to glioma tumor growth. Fluorescence molecular tomography and diffuse optical tomography
studies will be performed based on different optical markers potentially providing complementaryinformation.
The proposed methods will use structural anatomical images from x-ray tomography as prior information
enhancing the utility of optical tomography data. The research will be conducted in synergy with a clinical
trial underway at Dartmouth College evaluating how glioma tumor resection guided by fluoresence imaging
can positively affect patient survival. Darmouth has significant resources in the field of medical and
engineering graduate education, and the candidate will use this career transition award to train at Dartmouth
Hitchcock Medical Center, the Medical School and the Norris Cotton Cancer Center, with a central
appointment in the Engineering School. The candidate's research career will be developed by (i) taking
courses in medical engineering, tissue biochemistry and biostatistics, (ii)taking part in related events and
lectures, (iii)attending group meetings at the NCI funded Cancer Center, (iv) presenting research results at
oncology, radiology and imaging conferences, (v) planning with scientists working in biomedical companies
developing pre-clinical instruments, and (vi)making use of the NCI resources in molecular imaging agent
development.
RELEVANCE (Seeinstructions):
-The proposed project will lead to the development of a pre-clinical imaging system that can be used to
develop and test novel therapies designed to treat certain forms of cancer
-The results of this research will help us understand better the dynamics of a glioma brain tumor growth and
how they can be tracked and detected diagnostically.
项目负责人/主要研究者(最后,第一,中间):Leblond,Frederic
项目总结(见说明):
在转向光学成像领域之前,候选人曾在基础科学领域进行研究。
超弦理论领域的粒子物理学和广义相对论。长期职业目标
候选人是成为一个独立的研究人员谁拥有一套独特的知识和广度
在数值和分析建模以及生物医学工程和医学科学方面的经验
为了开发新的医学成像工具和应用,
管理候选人的近期目标是升级现有的混合X射线/近红外
用于临床前时域测量的断层扫描系统,使其成为神经胶质瘤成像的最佳选择
在老鼠身上长大。本提案的主要研究目标是开发新的数据采集方法,
创建断层扫描图像的算法,提供协同解剖和功能信息
与神经胶质瘤生长有关。荧光分子层析和扩散光学层析
将基于可能提供补充信息的不同光学标记进行研究。
所提出的方法将使用结构解剖图像从x射线断层扫描作为先验信息
增强了光学层析成像数据的效用。该研究将与临床研究协同进行。
达特茅斯学院正在进行的一项试验,评估如何通过荧光成像引导胶质瘤切除术
对病人的生存有积极的影响达茅斯在医疗领域拥有丰富的资源,
工程研究生教育,候选人将使用此职业过渡奖在达特茅斯接受培训
希区柯克医疗中心,医学院和诺里斯棉花癌症中心,与中央
在工程学院任职。候选人的研究生涯将通过(i)采取
医学工程、组织生物化学和生物统计学课程,㈡参加相关活动,
讲座,(iii)参加NCI资助的癌症中心的小组会议,(iv)在
肿瘤学、放射学和成像会议,(v)与在生物医学公司工作的科学家一起规划
开发临床前仪器,以及(vi)利用NCI在分子成像剂方面的资源
发展
相关性(参见说明):
- 拟议的项目将导致开发一个临床前成像系统,可用于
开发和测试旨在治疗某些类型癌症的新疗法
- 这项研究的结果将帮助我们更好地了解神经胶质瘤脑肿瘤生长的动力学,
如何跟踪和诊断它们。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Frederic Leblond其他文献
Frederic Leblond的其他文献
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{{ truncateString('Frederic Leblond', 18)}}的其他基金
X-ray/Fluorescence Molecular and Diffuse Optical Tomography of Glioma
胶质瘤的 X 射线/荧光分子和漫反射光学断层扫描
- 批准号:
7639764 - 财政年份:2009
- 资助金额:
$ 18.64万 - 项目类别:
X-ray/Fluorescence Molecular and Diffuse Optical Tomography of Glioma
胶质瘤的 X 射线/荧光分子和漫反射光学断层扫描
- 批准号:
8082790 - 财政年份:2009
- 资助金额:
$ 18.64万 - 项目类别:
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