Metal mixtures, children's cognition, and sensitive developmental windows
金属混合物、儿童认知和敏感发育窗口
基本信息
- 批准号:8566379
- 负责人:
- 金额:$ 10.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-05 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:13 year old4 year old7 year oldAddressAdolescenceAdolescentAreaAwardBiologicalBiological MarkersBiometryBirthBloodBody BurdenChemicalsChildChild DevelopmentChildhoodCitiesCognitionCognitiveComplexComplex MixturesCross-Sectional StudiesDataDevelopmentDimensionsElementsEnvironmental EpidemiologyEnvironmental ExposureEnvironmental HealthEpidemiologistEpidemiologyEquationExposure toGoalsHairHealthIndividualInstructionItalyJointsLeadLifeLinkLongitudinal StudiesMachine LearningMeasuresMentorshipMetal exposureMetalsMethodsMexicoModelingNail plateNational Institute of Environmental Health SciencesNeurologyNeurotoxinsPerinatal ExposurePhasePhenotypePredispositionPrincipal InvestigatorPublic HealthResearchResearch PersonnelResearch TrainingRisk AssessmentSamplingScienceScientistSourceStagingStatistical MethodsTestingTimeToxic effectToxicologyTrainingUncertaintyUrineanalytical toolcohortcost effectivedeciduous toothearly life exposureexperienceforestinnovationlead exposurelongitudinal designneurodevelopmentneurotoxicneurotoxicitynovelprenatalpublic health prioritiespublic health relevanceskillssymposiumsynergismtoxicant
项目摘要
DESCRIPTION (provided by applicant)
Mixtures are a common exposure scenario but are rarely studied. Metals comprise a class of chemicals to which co-exposure is common and whose neurotoxic effects, particularly, can be severe, making them a potentially paradigm class of chemicals for mixtures research. Research on individual metals, such as lead, has been robust; but research on metal mixtures is lacking. Major challenges impeding progress in mixtures research include the lack of sufficient exposure data for multiple metals. Even when multiple metal exposure biomarkers are collected, there remains a lack of analytical tools to fully evaluate interactions. Under the mentorship of Drs. Coull and Lucchini, Dr. Claus Henn (principal investigator) will overcome barriers in mixtures research by using cutting-edge statistical learning methods, combined with robust data on host exposure to mixed metals. By doing so, she will evaluate the joint effects of multiple metals on neurodevelopment. This K99/R00 application builds upon Dr. Claus Henn's experience in environmental epidemiology and exposure science to cross train her in child development and biostatistics and prepare her to become an independent investigator specializing in chemical mixtures and pediatric environmental health. In the K99 phase of the award, Dr. Claus Henn will use tutorials, didactic instruction, and seminars/conferences to receive training in: 1) advanced quantitative methods for use in analyzing combined exposures, and 2) childhood neurodevelopment from the prenatal period through adolescence. These areas of training represent a new cross-disciplinary goal for Dr. Claus Henn. Her training will subsequently be applied in an existing cohort of 750 Italian adolescents in the Public Health Impact of Mixed Element exposure (PHIME) study. Dr. Claus Henn will apply structural equation models, random forests, and kernel regression machines to examine cognitive effects of concurrent exposure to combinations of metals. In the R00 phase, Dr. Claus Henn will evaluate whether cognitive effects of exposure to combinations of metals depend on exposure timing. Using data from the Early Life Exposure in Mexico to Environmental NeuroToxicants (ELEMENT) longitudinal birth cohort, she will apply the aforementioned methods at multiple exposure time points, across the prenatal period and childhood. This cross-disciplinary proposal represents a unique opportunity to efficiently use existing data in an innovative yet cost-effective manner. The
proposed training and research will provide Dr. Claus Henn with the skills to study the joint effects of multiple chemicals and multiple time points on neurodevelopment in future research. This research will 1) address the large data gap on health effects of chemical mixtures, and 2) help characterize critical windows of susceptibility to neurotoxicants; both are NIEHS strategic goals and public health priorities.
描述(由申请人提供)
混合物是一种常见的接触情况,但很少研究。金属是一类共同接触的化学品,其神经毒性效应尤其严重,使其成为混合物研究的潜在化学品范例。对铅等单一金属的研究一直很活跃,但对金属混合物的研究却很缺乏。 阻碍混合物研究取得进展的主要挑战包括缺乏多种金属的充分接触数据。即使收集了多种金属暴露生物标志物,仍然缺乏分析工具来充分评估相互作用。在Coull和Lucchini博士的指导下,Claus Henn博士(首席研究员)将通过使用尖端的统计学习方法,结合宿主暴露于混合金属的可靠数据,克服混合物研究中的障碍。 通过这样做,她将评估多种金属对神经发育的联合影响。这个K99/R 00应用程序建立在Claus Henn博士在环境流行病学和暴露科学方面的经验基础上,对她进行儿童发育和生物统计学方面的交叉培训,并使她成为一名专门从事化学混合物和儿科环境健康的独立调查员。 在K99阶段,Claus Henn博士将使用教程、教学指导和研讨会/会议来接受以下方面的培训:1)用于分析组合暴露的先进定量方法,以及2)从产前到青春期的儿童神经发育。这些培训领域代表了Claus Henn博士新的跨学科目标。她的培训随后将应用于现有的750名意大利青少年的混合元素暴露(PHIME)研究的公共卫生影响。 Claus Henn博士将应用结构方程模型、随机森林和核回归机器来研究同时接触金属组合的认知影响。在R 00阶段,Claus Henn博士将评估暴露于金属组合的认知影响是否取决于暴露时间。使用来自墨西哥环境神经毒物(ELEMENT)纵向出生队列的早期生命暴露数据,她将在产前和童年的多个暴露时间点应用上述方法。这一跨学科的建议是一个独特的机会,以创新但具有成本效益的方式有效地利用现有数据。的
拟议的培训和研究将为Claus Henn博士提供在未来研究中研究多种化学物质和多个时间点对神经发育的联合影响的技能。这项研究将1)解决化学混合物对健康影响的巨大数据缺口,2)帮助描述神经毒物敏感性的关键窗口;两者都是NIEHS的战略目标和公共卫生优先事项。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Birgit Gunhild Claus Henn其他文献
Birgit Gunhild Claus Henn的其他文献
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