2013 Molecular and Cellular Biology of Lipids Gordon Research Conference

描述(由申请者提供)：本申请请求部分支持2013年脂质分子和细胞生物学戈登研究会议(GRC)，该会议汇集了脂质领域的领先科学家，介绍和讨论他们的研究，并促进研究进展。近50年来，脂类GRC每隔一年举行一次，是国际公认的展示脂类生物化学和分子生物学开创性和创新性研究的主要论坛。2013年，会议将重点关注血脂的持续出现，以了解肥胖、肝脏脂肪变性、心肌病、动脉粥样硬化和糖尿病等慢性疾病发生的潜在机制。创新包括：a)选择新参加会议的发言者，b)以前没有受到关注的新主题，c)增加初级和高级研究人员参与科学讨论的机会。新的主题包括自噬，以脂肪酸为配体的G偶联蛋白受体，硫代酯酶的代谢和功能，磷脂酸盐信号，以及全球调节脂质代谢的microRNAs。在2013年的另一项创新中，我们将留出特定的桌子，让初级参与者可以与演讲者共进午餐。会议将于7月17日至22日在密西西比州沃特维尔山谷的沃特维尔山谷度假村举行，将包括9个讲座和4个下午的海报会议。讲座将涵盖广泛的主题，包括调节细胞新陈代谢的脂肪信号，脂肪酶和酰基转移酶的新作用，膜生物发生和周转，细胞脂肪代谢，脂肪酸代谢，脂类的转录控制，磷脂酸盐的聚焦，以及通过microRNAs对脂类的遗传调控。在这些会议上，35名演讲者将介绍使用多种实验方法在一系列生物系统中所做的研究，包括人类、寄生虫、斑马鱼和酵母。在脂质的分子和细胞生物学GRC上的演讲，以及大型而生动的海报会议，传统上会在与会者之间引发激烈和动态的讨论，其中包括生物化学家、细胞生物学家、遗传学家、分子生物学家、结构生物学家、生理学家和内科医生。会议的亲密气氛限制在200人以内，使与会科学家能够近距离互动。由此产生的讨论推动了该领域未来的进步和多学科合作。与会者和演讲者已经并将被挑选出来，以反映这一与医学相关的科学领域的国际卓越表现，并在青年和经验之间取得理想的平衡。该项目包括杰出的女性和男性，以及不同种族的科学家。设有设施以收容残疾人士。

DESCRIPTION (provided by applicant): This application requests partial support for the 2013 Molecular and Cellular Biology of Lipids Gordon Research Conference (GRC), a meeting that brings together leading scientists in the lipid field to present and discuss their research and to facilitate research advances. This Lipids GRC has been held every other year for almost 50 years and is internationally recognized as the major forum for the presentation of ground breaking and innovative research in lipid biochemistry and molecular biology. In 2013, the conference will focus heavily on the continuing emergence of lipids in understanding underlying mechanisms involved in the development of chronic diseases like obesity, hepatic steatosis, cardiomyopathy, atherosclerosis, and diabetes. Innovations include the selection of a) speakers who are new to this conference, b) novel topics that have not previously received attention, and c) enhanced opportunities for junior and senior investigators to engage in scientific discussion. New topics include autophagy, G-coupled protein receptors whose ligands are fatty acids, thioesterase metabolism and function, phosphatidate signaling, and microRNAs that globally regulate lipid metabolism. In another 2013 innovation, we will set aside specific tables where junior participants can meet the speakers for lunch. The meeting will be held July 17 - 22 at the Waterville Valley Resort in Waterville Valley, NH, and will include nine lecture sessions and four afternoon poster sessions. Lecture sessions will cover a broad range of topics, including Lipid signals that regulate cell metabolism, New roles for lipases and acyltransferases, Membrane biogenesis and turnover, Cellular lipid metabolism, Fatty acid metabolism, Transcriptional control of lipids, a Spotlight on phosphatidate, and the Genetic regulation of lipids via microRNAs. The >35 speakers in these sessions will describe research done in an array of biological systems, including humans, parasites, zebra-fish, and yeast, using multiple experimental approaches. The talks at the Molecular and Cellular Biology of Lipids GRC, as well as the large and lively poster sessions, traditionally stimulate intense and dynamic discussions among the attendees who include biochemists, cell biologists, geneticists, molecular biologists, structural biologists, physiologists, and physicians. The intimate atmosphere of the meeting, which is limited to 200 participants, enables attending scientists to interact closely with each other. The resulting discussions drive future advances and multidisciplinary collaborations in the field. Participants and speakers have been and will be chosen to reflect international excellence in this medically-relevant area of science, with an ideal balance between youth and experience. The program includes outstanding women and men, and scientists of different ethnicities. Facilities are available to accommodate handicapped individuals.