SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS

该研究与开发(R&D)合同的目的是为国家毒理学计划(NTP)替代毒理学方法评估机构间中心(NICEATM)提供科学和行政支持。NICEATM研究支持机构间替代方法验证协调委员会(ICCVAM)的活动。NICEATM负责确保遵守《ICCVAM授权法案200》(《美国法典》第42编第285l-3条)的职责和规定。NICEATM通过执行独立的研发活动来履行其使命，包括审查拟议的测试方法、组织研讨会和促进同行审查。拟议的测试方法包括由开发人员提交给ICCVAM的方法，以及由公众或组成ICCVAM的成员机构提名的需要进行额外验证研究的方法。NICEATM将利用其研发支持合同，开发和验证各种体外和计算方法，这些方法可以用来更准确地预测对人类健康的影响，同时还可以取代或减少在毒性测试中使用动物。

The objective of this Research and Development (R&D) contract is to provide scientific and administrative support to the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NICEATM research supports activities of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). NICEATM is responsible for ensuring compliance with the duties and provisions of the ICCVAM Authorization Act of 200 (42 U.S.C. 285l-3). NICEATM carries out its mission by performing independent R&D activities including reviewing proposed test methods, organizing workshops, and facilitating peer reviews. Proposed test methods include those submitted to ICCVAM by developers as well as those nominated by the general public or Member Agencies making up ICCVAM that require additional validation studies. NICEATM, through use of its R&D support contract, will develop and validate a variety of in vitro and computational approaches that can be used to more accurately predict human health effects while also replacing or reducing the use of animals in toxicity testing.