SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS

NTP 跨机构中心的支持合同/替代方法的验证

• 批准号: 8655502
• 负责人: DAVID ALLEN
• 金额: $ 127.69万
• 依托单位: INTEGRATED LABORATORY SYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-16 至 2013-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8655502
• 关键词: Animals; Authorization documentation; Chemicals; Contracts; Educational workshop; Ensure; Evaluation; General Population; Goals; Hazard Identification; Health; Human; In Vitro; Interagency Coordinating Committee on the Validation of Alternative Methods; Knowledge; Methods; Mission; National Toxicology Program; Peer Review; Preparation; Research Support; Risk Assessment; Support Contracts; Testing; Toxicity Tests; Validation; meetings; member; novel; research and development; validation studies; web site

The objective of this Research and Development (R&D) contract is to provide scientific and administrative support to the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NICEATM research supports activities of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). NICEATM is responsible for ensuring compliance with the duties and provisions of the ICCVAM Authorization Act of 200 (42 U.S.C. 285l-3). NICEATM carries out its mission by performing independent R&D activities including reviewing proposed test methods, organizing workshops, and facilitating peer reviews. Proposed test methods include those submitted to ICCVAM by developers as well as those nominated by the general public or Member Agencies making up ICCVAM that require additional validation studies. NICEATM, through use of its R&D support contract, will develop and validate a variety of in vitro and computational approaches that can be used to more accurately predict human health effects while also replacing or reducing the use of animals in toxicity testing.

该研发 (R&D) 合同的目的是为国家毒理学计划 (NTP) 替代毒理学方法评估跨机构中心 (NICEATM) 提供科学和行政支持。 NICEATM 研究支持替代方法验证机构间协调委员会 (ICCVAM) 的活动。 NICEATM 负责确保遵守 ICCVAM 授权法案 200 (42 U.S.C. 285l-3) 的职责和规定。 NICEATM 通过开展独立研发活动来履行其使命，包括审查提议的测试方法、组织研讨会和促进同行评审。提议的测试方法包括由开发人员提交给 ICCVAM 的测试方法以及由公众或组成 ICCVAM 的成员机构提名的需要额外验证研究的测试方法。 NICEATM 通过利用其研发支持合同，将开发和验证各种体外和计算方法，这些方法可用于更准确地预测人类健康影响，同时取代或减少毒性测试中动物的使用。