NICEATM Support Contract: Contractor Travel

这是一份研发(R&D)合同，为国家毒理学计划(NTP)替代毒理学方法评估机构间中心(NICEATM)提供科学和行政支持。NICEATM研究总体上支持NTP的活动，特别是NTP的生物分子筛选处(BSB)、Tox21联盟和替代方法验证机构间协调委员会(ICCVAM)。 承包商必须获得和应用新的和现有的科学知识，以开发、评估和验证可用于与人类健康直接相关的化学危险识别和风险评估的新的计算方法。数据开发、分析和评估代表了此需求的大部分工作。这些方法包括但不限于：暴露建模、基于生理的药代动力学/药效学(PBPK/PD)建模、反向毒代动力学(R-TK)建模、定量构效关系(QSAR)建模、定量高通量筛选(QHTS)和高含量(HC)数据的分析，以及使用体内、体外和/或硅系统开发新型集成测试和决策策略(ITDS)。承包商通常使用来自不同数据类型和多个数据库(例如，ToxRef DB、ToxCastDB、ExpoCastDB、DSSTox、CEBS等)的信息。开发和评估以上列出的方法。 为了探索替代方法的实用性，承包商识别、检索和比较从新方法产生的数据和从出版的文献中找到的传统方法的现有数据。承包商使用公共和专有数据库，收集选定化学品和混合物的所有相关生产、使用、暴露和毒理学信息，这些信息目前包括在Tox21相关工作或NTP感兴趣的工作中或供考虑纳入。承包商审查和评估从文献搜索中收集的数据和信息，并根据需要编写全面的书面报告。

This is a Research and Development (R&D) contract to provide scientific and administrative support for the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NICEATM research supports activities of NTP in general, and specifically, NTP’s Biomolecular Screening Branch (BSB), the Tox21 consortium, and the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). The Contractor is required to acquire and apply new and existing scientific knowledge to develop, evaluate, and validate novel computational approaches that can be used for chemical hazard identification and risk assessment with direct relevance to human health. Data development, analysis, and evaluation represents a large portion of the work of this requirement. These approaches include, but are not limited to: exposure modeling, physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling, reverse toxicokinetic (R-TK) modeling, Quantitative Structure-Activity Relationship (QSAR) modeling, analysis of quantitative high throughput screening (qHTS) and high content (HC) data, and development of novel Integrated Testing and Decision Strategies (ITDS) using in vivo, in vitro and/or in silico systems. The Contractor routinely utilizes information from diverse data types and multiple databases (e.g., ToxRef DB, ToxCastDB, ExpoCastDB, DSSTox, CEBS, etc.) to develop and evaluate the above listed approaches. To explore the utility of alternative methods, the Contractor identifies, retrieves, and compares data generated from novel methods with extant data from traditional methods found in the published literature. Using public and proprietary databases, the Contractor gathers all relevant production, use, exposure, and toxicological information on selected chemicals and mixtures currently included in or inder consideration for inclusion in Tox21-related efforts or of interest to the NTP. The Contractor reviews and evaluates the data and information gathered from the literature searches and prepares comprehensive written reports, as needed.