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The Role of Endothelin-1 in Sickle Cell Disease

Endothelin-1 在镰状细胞病中的作用

基本信息

批准号：
8467879
负责人：
Abdullah Kutlar
金额：
$ 166.04万
依托单位：
AUGUSTA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-15 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8467879
关键词：
Adult Albuminuria Area Basic Science Blood Circulation Blood flow Childhood Clinical Clinical Sciences Clinical Trials Development Development Plans Education Endothelin Endothelin-1 Functional disorder Funding Funding Opportunities Goals Grant Health Sciences Hematological Disease Hemoglobinopathies Hypoxia Inflammation Informatics Inherited Injury Interdisciplinary Study Kidney Kidney Diseases Knowledge Laboratories Lung Mentors Nociception Nociceptors Organ Pain Pain Research Pathogenesis Patients Peripheral Preparation Problem Solving Recording of previous events Renal function Research Research Activity Research Infrastructure Research Personnel Research Project Grants Research Training Role Sickle Cell Sickle Cell Anemia Staging Students Testing Training Training Programs Transgenic Mice Translational Research Universities Vascular Diseases Writing career career development chronic pain experience high school improved interest mouse model multidisciplinary programs receptor safety study sickling skills social science research

项目摘要

DESCRIPTION (provided by applicant): The Sickle Cell Center at Georgia Health Sciences University has a long-standing history of excellence in hemoglobinopathies research, particularly in the area of sickle cell disease. This funding opportunity brings together a group of distinguished researchers in the fields of sickle cell disease (basic, clinical, and translational), endothelin, basic research in kidney disease, studies in a mouse model of sickle cell disease (SCD), and pain research. The goal of this project is tripartite: 1) To study the role of endothelin-1 in SCD with regards to inflammation, vasculopathy, lung and kidney injury, and pain; 2) To train new investigators in multidisciplinary research activities in sickle cell disease and promote research interest in high school students through a summer student program; 3) To provide administrative and informatics infrastructure for the centers funded through this initiative. To achieve these goals, a multidisciplinary team of experts has been assembled to identify the role of endothelin-1 in SC. The role of endothelin-1 in the pathogenesis of vasculopathy, inflammation, organ damage, and pain and nociception will be studied in a transgenic mouse model of SCD. In Years 4 and 5 of this project, a small pilot clinical trial will be initiated to study safety and efficacy of an ETA receptor blockade on inflammation, pain, nociception, and the progression of sickle nephropathy and on microvascular blood flow and pulmonary arterial circulation in adults with SCD. The Translational Research Skills Development Core will train early stage investigators how to conduct high impact, multidisciplinary, translational, hemoglobinopathy research. This core will also train scholars to write competitive K or ROI grants to support transition to independent translational research careers. The Administrative Coordinating Center will provide support for the administrative and coordinating activities and create and maintain the informatics infrastructure necessary to support the activities of the EHRA program.

描述（由申请人提供）：