Prevention of Thrombosis by NO Secreting Polymers

通过分泌 NO 的聚合物预防血栓形成

• 批准号: 8522219
• 负责人: Hitesh Handa
• 金额: $ 14.79万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-03 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8522219
• 关键词: Address; Adherence; Adhesions; Air; Artificial Organs; Award; Biocompatible Materials; Biological Sciences; Biology; Biomedical Engineering; Biomedical Research; Blood; Blood Platelets; Blood flow; Caring; Catheters; Chemistry; Chronic; Clinical; Clinical Engineering; Coagulation Process; Collagen; Complex; Conscious; Data; Development; Devices; Endothelium; Engineering; Environment; Exhibits; Exposure to; Extracorporeal Circulation; Faculty; Fibrin; Foundations; Generations; Glycolates; Goals; Grant; Health Care Costs; Heparin; Heparin Binding; Hour; Image; Indwelling Catheter; Infection; Intensive Care Units; Knowledge; Laboratories; Medical; Medical Device; Medicine; Mentors; Metals; Michigan; Microbial Biofilms; Modeling; Modern Medicine; Modification; Molecular; Nitric Oxide; Operative Surgical Procedures; Oryctolagus cuniculus; Patients; Physiology; Plastics; Platelet Activation; Polymers; Prevention; Prosthesis; Research; Research Personnel; Research Project Grants; Role; Science; Scientist; Simulate; Solid; Stents; Students; Surface; Surgeon; System; Testing; Thrombin; Thrombosis; Thrombus; Tissues; Training; Translational Research; Transplantation; Universities; Venipunctures; Venous; Venous Thrombosis; base; career; clinical application; diazeniumdiolate; experience; implantation; in vitro testing; member; novel; prevent; prototype; research study; skills; success

DESCRIPTION (provided by applicant): The goal of this award is to develop an expert in blood/materials science. Why this project; why this candidate; and why this environment? Blood flows through the envelope of endothelium for a lifetime without clotting. When blood contacts anything but endothelium (collagen tissue, air, metal, plastic) it clots in a few seconds. This is normal physiology. Most of modern medicine depends on understanding these phenomena. We take advantage of it to allow all surgical procedures from venipuncture to transplantation. We try to prevent it when blood contacts medical devices from simple catheters to complex artificial organs. Better understanding of the physiology will result in better, safer blood contact devices which will impact all of medicine. For 100 years this research was focused on the components of the blood. Now it is focused on the endothelium. A blood/materials expert brings basic engineering and biologic science to the benefit of patients in every field of medicine. Dr. Hitesh Handa has the basic engineering knowledge. He also has the practical experience in development of blood contact devices. To this background he will add the chemistry of the endothelium, the biologic systems to evaluate materials, and experience in clinical application. In five years he will be on the small but vital roster of experts in blood/materials science. The combination of mentors, facilities and expertise at the University of Michigan provides an outstanding environment for Dr. Handa's development. Dr. Bartlett is a clinical surgeon and intensivist who has taken clinical problems to the biology laboratory for decades. Dr. Mark Meyerhoff is a basic scientist who has taken molecular chemistry to the biology laboratory for decades. Their combined research is focused on simulating the normal endothelium. Their students are among the experts in blood/materials science, from chemists and research biologists to industrial developers to clinical practitioners. .

描述（由申请人提供）：该奖项的目标是培养血液/材料科学领域的专家。为什么这个项目；为什么选择这个候选人；为什么是这个环境？血液终生流经内皮细胞膜而不发生凝结。当血液接触内皮以外的任何物质（胶原组织、空气、金属、塑料）时，它会在几秒钟内凝结。这是正常的生理现象。大多数现代医学依赖于对这些现象的理解。我们利用它来允许从静脉穿刺到移植的所有外科手术。当血液接触医疗设备（从简单的导管到复杂的人造器官）时，我们尽力防止这种情况发生。对生理学的更好理解将带来更好、更安全的血液接触装置，这将影响所有医学。一百年来，这项研究一直集中在血液成分上。现在它的重点是内皮细胞。血液/材料专家将基础工程和生物科学带给各个医学领域的患者。 Hitesh Handa 博士拥有基本的工程知识。他还拥有血液接触装置开发的实践经验。在此背景下，他将添加内皮化学、评估材料的生物系统以及临床应用经验。五年后，他将跻身血液/材料科学领域虽小但至关重要的专家名册上。密歇根大学的导师、设施和专业知识相结合，为Handa博士的发展提供了优越的环境。 Bartlett 博士是一名临床外科医生和重症监护医师，几十年来一直将临床问题带入生物实验室。马克·迈耶霍夫 (Mark Meyerhoff) 博士是一位基础科学家，几十年来一直将分子化学带入生物实验室。他们的联合研究重点是模拟正常内皮。他们的学生都是血液/材料科学领域的专家，从化学家和研究生物学家到工业开发人员再到临床从业者。 。