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Metal organic framework-based antithrombotic surfaces

基于金属有机骨架的抗血栓表面

基本信息

批准号：
10155583
负责人：
Hitesh Handa
金额：
$ 35.95万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10155583
关键词：
Achievement Acute Address Animal Model Anticoagulants Biochemical Biological Biological Process Blood Blood Platelets Blood Pressure Catheters Cell Culture Techniques Cellular Assay Cessation of life Chronic Coagulation Process Conscious Copper Critical Illness Custom Devices Equipment Malfunction Evaluation Failure Functional disorder Grant Half-Life Health Expenditures Healthcare Hemostatic function Heparin Hepatocyte Human In Vitro Inductively Coupled Plasma Mass Spectrometry Infection Inflammation Intravenous Ions Lead Length Measures Mechanics Medical Device Metals Methemoglobin Modeling Modification Morbidity - disease rate Nature Nitric Oxide Nitric Oxide Donors Oryctolagus cuniculus Patient Care Patients Performance Pharmacotherapy Physiological Platelet Activation Polymers Polyurethanes Pre-Clinical Model Production Property Research S-Nitrosothiols Safety Silicone Elastomers Source Spectrum Analysis Stream Structure Surface System Techniques Technology Testing Therapeutic Therapeutic Agents Thrombosis Thrombus Time Tissues Toxic effect Translations Work base catalyst chemical property clinical application clinical practice clinically relevant clinically significant design dosage experimental study hemocompatibility implantable device improved in vitro Assay in vitro Bioassay in vitro Model in vivo mechanical device mechanical properties novel novel strategies patient population platelet function prevent prototype side effect standard of care therapeutic target

项目摘要

ABSTRACT: Each year billions of health care dollars are spent on medical devices that fail in clinical practice. These device failures occur over various timescales of the devices due to multiple factors including thrombosis, inflammation, infection, and tissue overgrowth on the surface of the implanted device as well as mechanical device failures. Over the last 50 years, much has been learned about these device failures resulting in attempts to prevent failures using (1) alternative systemic drug therapies, (2) surface modifications on the device, or (3) a combination of both approaches. Despite efforts to improve the efficacy of blood-contacting and implantable medical devices, the incompatibility of these materials within human blood and tissue still causes serious complications in patients. Thus, systemic or regional drug therapies such as heparin remain necessary. As a result, strategies that can leverage the biological properties of naturally occurring bioagents such as nitric oxide (NO) have clear implications for a wide variety of medical devices. These materials offer localized control of platelets at the blood-material interface where bioactivity is targeted. The research strategy detailed here in focuses on developing materials that can produce NO from endogenous sources for extended periods of time and will overcome the fundamental limitations of current NO materials. Using metal organic frameworks (MOFs) as NO catalysts, device coatings will now be able to (1) produce NO for longer time period than ever achieved to date and (2) allow systematic modification while maintaining the structural properties that make them suitable for clinical applications. The principal premise of this project proposal is to utilize the inherent structural features of MOF materials to develop physiologically-relevant NO catalysts for use in catheter coatings. As a part of this grant, MOFs will be prepared, blended into catheter coatings and rigorously tested for their long- term function and mechanical properties, evaluated for safety via toxicity studies and characterized by an array of in vitro bioassays. Final catheter prototypes will be tested in a rabbit model for their anti-thrombotic properties at time points beyond the capabilities of current technologies.

文摘:

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Computational Insights into the Mechanism of Nitric Oxide Generation from S-Nitrosoglutathione Catalyzed by a Copper Metal-Organic Framework.

DOI：
10.1021/jacs.3c01569
发表时间：
2023-05
期刊：
Journal of the American Chemical Society
影响因子：
15
作者：
Benjamin J G Rousseau;A. Soudackov;Robert R. Tuttle;Melissa M. Reynolds;R. Finke;S. Hammes‐Schiffer
通讯作者：
Benjamin J G Rousseau;A. Soudackov;Robert R. Tuttle;Melissa M. Reynolds;R. Finke;S. Hammes‐Schiffer

Nitric Oxide-Releasing Emulsion with Hyaluronic Acid and Vitamin E.

含有透明质酸和维生素 E 的一氧化氮释放乳液。