Assessment of Upper Airway Mechanics Using Newer EMG Techniques

使用更新的肌电图技术评估上呼吸道力学

• 批准号: 8701159
• 负责人: Atul Malhotra
• 金额: $ 16.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8701159
• 关键词: Address; Advocate; Affect; Animals; Arousal; Award; Behavior; Behavioral; Breathing; Carbon Dioxide; Cardiovascular system; Chemical Stimulation; Data; Deglutition; Denervation; Development; Dilator; Disease; Drops; Environmental air flow; Fiber; Frequencies; Goals; High Prevalence; Human; Hypercapnia; Hypertension; Individual; Instruction; Iron; Lead; Lung; Maintenance; Mechanical Stimulation; Mechanics; Mediating; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; Motor; Muscle; Neuroanatomy; Neurocognitive; Obstructive Sleep Apnea; Pathogenesis; Patients; Pattern; Phase; Principal Investigator; REM Sleep; Recruitment Activity; Research; Research Activity; Research Personnel; Research Project Grants; Respiratory physiology; Role; Sampling; Series; Sleep; Sleep Apnea Syndromes; Source; Stimulus; Stroke; Techniques; Testing; Time; Tongue; Training; Trigeminal Nuclei; Wakefulness; Withdrawal; Work; awake; base; career development; density; falls; improved; insight; interest; motor control; neuroregulation; new therapeutic target; novel strategies; pressure; prevent; programs; reinnervation; relating to nervous system; research study; respiratory; response; sleep onset; therapeutic target; vehicular accident

Program Director/Principal Investigator (Last, First, Middle): Malhotra, Atul, MD PROJECT SUMMARY (Seeinstructions): Immediate goals: To apply newer electromyographic techniques to upper airway muscles with a view towards identifying important therapeutic targets in obstructive sleep apnea. Career development goals: To provide sufficient time for mentoring of trainees and research activities. Research project: Obstructive sleep apnea is an important disease due to its high prevalence and well established neurocognitive and cardiovascular sequelae. Treatment of this disease remains problematic since the existing therapies are either poorly tolerated or have variable efficacy, leading many to advocate for further research into underlying mechanisms. Prior research has established in the importance of the upper airway muscles (such as the genioglossus and tensor palatini) in the pathogenesis of sleep apnea. However, multi-unit electromyographic recordings provide an average representation of innumerable motor units yielding fairly incomplete information about the behavior of individual motor units. We have begun a series of studies using high frequency sampling of the electromyogram to define the various motor units within the genioglossus muscle. These newer studies have revealed marked complexity in the behavior of the genioglossus muscle, with 6 distinct firing patterns being identifiable. A rise or fall in the genioglossal multiunit EMG is therefore difficult to interpret since these changes could be mediated by any of a number of individual motor unit firing changes. We have observed specific units that may be most critical for the maintenance of pharyngeal patency. Such units would thus we logical therapeutic targets which we can address with our neuroanatomy collaborators. We have also begun studies using single fiber EMGs and MacroEMGs which a view towards performing more quantitative assessments of various upper airway muscles. These newer EMG techniques will allow us to assess the mechanisms underlying the high level of activity seen in the EMG of sleep apnea patients as compared with controls, since there is currently an ongoing controversy as to whether this high activity represents high central drive to the muscle versus an effect of denervation. This K24 award would allow us to pursue interesting hypotheses that may ultimately lead to new treatments for sleep apnea, but will certainly yield insights into disease pathogenesis. This award will also allow the PI to dedicate more time to training young investigators in the field of sleep and respiratory physiology. The need for an investigator pipeline has been termed a crisis (Sleep. 2006 29:1260) RELEVANCE (See instructions): Obstructive sleep apnea is strongly implicated in motor vehicle accidents as well as high blood pressure and stroke. How easily an individual wakes up from sleep (arousal threshold) is something that may be important in why sleep apnea occurs. We propose studies that will examine the role of the arousal threshold with an ultimate goal of developing new treatments for sleep apnea to prevent its serious complications. PROJECT/

项目主管/首席研究员（最后，第一，中间）：Malhotra, Atul， MD

项目成果

A review of signals used in sleep analysis.

• DOI: 10.1088/0967-3334/35/1/r1
• 发表时间: 2014-01
• 期刊: Physiological measurement
• 影响因子: 3.2
• 作者: Roebuck A;Monasterio V;Gederi E;Osipov M;Behar J;Malhotra A;Penzel T;Clifford GD
• 通讯作者: Clifford GD

A comparison of methods to identify open-lung PEEP.

• DOI: 10.1007/s00134-009-1412-9
• 发表时间: 2009-04
• 期刊: INTENSIVE CARE MEDICINE
• 影响因子: 38.9
• 作者: Caramez, Maria Paula;Kacmarek, Robert M.;Helmy, Mohamed;Miyoshi, Eriko;Malhotra, Atul;Amato, Marcelo B. P.;Harris, R. Scott
• 通讯作者: Harris, R. Scott

Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study.

• DOI: 10.1016/j.ajog.2009.05.032
• 发表时间: 2009-11
• 期刊: American journal of obstetrics and gynecology
• 影响因子: 9.8
• 作者: Wiznitzer A;Mayer A;Novack V;Sheiner E;Gilutz H;Malhotra A;Novack L
• 通讯作者: Novack L