Innovative use of hydrogel technology to recapitulate and investigate cardiac pathology.

创新地使用水凝胶技术来概括和研究心脏病理学。

• 批准号: nhmrc : GNT1143203
• 负责人: Dr Helena Viola
• 金额: $ 71.62万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/innovative-use-hydrogel-cardiac-pathology/1348510
• 关键词: Innovative; use; hydrogel; technology; recapitulate

Hypertrophic cardiomyopathy is the leading cause of sudden death in the young. No treatment exists that can reverse or prevent it, primarily because the underlying mechanisms of the disease have not been fully elucidated. I will use innovative hydrogel technology to simulate the disease state. I will use this as a tool to identify the mechanisms involved with development of the disease. This will enable identification of potential therapeutic targets for prevention of the disease.

肥厚型心肌病是年轻人猝死的主要原因。目前还没有可以逆转或预防这种疾病的治疗方法，主要是因为这种疾病的潜在机制尚未完全阐明。我将使用创新的水凝胶技术来模拟疾病状态。我将利用这一点作为一种工具来确定与疾病发展有关的机制。这将有助于确定预防该疾病的潜在治疗目标。