The Epidemiology of Postpartum Depression and Associated Childhood Outcomes.

产后抑郁症和相关童年结局的流行病学。

• 批准号: 8583670
• 负责人: Michael Evan Silverman
• 金额: $ 25.61万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8583670
• 关键词: Achievement; Address; Adolescence; Affect; Age; Attention; Behavioral; Birth; Censuses; Characteristics; Child; Child Development; Child health care; Childhood; Clinical; Clinics and Hospitals; Cognitive; Collaborations; Complication; Data; Databases; Development; Diagnosis; Diagnostic; Discipline of obstetrics; Disease; Education; Emotional; Epidemiology; Ethnic Origin; Event; Female; Financial cost; Frequencies; Gender; Gestational Diabetes; Health; Hospitalization; Housing; Impairment; Incidence; Infant; Inpatients; International; Life; Link; Maternal Age; Maternal Behavior; Medical; Mental Depression; Mental Health; Mental disorders; Methods; Mission; Moods; Morbidity - disease rate; Mothers; National Institute of Mental Health; New York; Newborn Infant; Outcome; Outpatients; Patients; Pattern; Personal Satisfaction; Pharmacy facility; Population; Population Registers; Postpartum Depression; Postpartum Period; Poverty; Pre-Eclampsia; Pregnancy; Premature Birth; Prenatal care; Prevalence; Psychiatric Diagnosis; Psychotic Disorders; Public Health; Publications; Race; Recording of previous events; Reporting; Research; Resources; Risk; Risk Factors; Role; Route; Sampling; Schools; Severities; Socioeconomic Status; Statistical Methods; Sweden; Technology Assessment; Time; United States Agency for Healthcare Research and Quality; Work; base; child bearing; clinical Diagnosis; clinically significant; cohort; contextual factors; demographics; depressive symptoms; experience; health care service utilization; improved; insight; knowledge base; maternal depression; nervous system disorder; neurobehavioral; offspring; population based; prevent; programs; public health relevance; single episode major depressive disorder; treatment planning; trend

DESCRIPTION (provided by applicant): The Aims of this project are a direct answer to the mission of the NIMH to address the epidemiology of postpartum depression, to identify associated risk factors and characterize child developmental and mental health outcomes associated with clinically significant postpartum mood change. Postpartum depression is the most common complication of childbearing (Wisner KL, Chambers C, Sit D. Postpartum depression: A major public health problem. JAMA 2006~296:2616-2618), evident in approximately 11%-19% of all new mothers (Evidence Report / Technology Assessment 119. AHRQ Publication 05-E006-2). To date, most research on postpartum depression has relied on small convenience samples from clinics or hospitals that cannot generate normative data and utilize varying diagnostic criteria that more often focus on depressive symptomatology rather than clinical diagnoses of depression. This study builds on the unique resources for research on mental health available in Sweden. Linking a constellation of Swedish registers, including the National Patient Registers of health and health service utilization, National School Register, National Pharmacy Register, Total Population Register and Housing Census, we will: (a) expand upon the current knowledge base of the epidemiology of postpartum depression by more accurately describing the magnitude and pattern of clinically significant postpartum depression (hospitalized and non-hospitalized) and associated risk factors and~ (b) comprehensively characterize the child development outcomes of maternal postpartum depression. We will utilize advanced statistical methods to identify the developmental consequences of postpartum depression assessing which children of postpartum depressed mothers are more or less likely to develop problems, whether explained by maternal characteristics, such as depression timing, severity, subtypes (with and without psychosis) or comorbid conditions, child characteristics such as gender, or contextual factors such as poverty. The aims of the study are ambitious, but we have established a team of international experts with a long history of collaboration, which is well suited to address the study Aims. For predictive purposes, evaluating a comprehensive set of potential determinants of postpartum depression will generate new insights to help predict, identify, and ultimately help to prevent and treat this disorder. Because the period immediately following the birth of a child is a critica time and postpartum depression constitutes a serious threat to the infant's well-being, the epidemiologic characterization of clinically significant postpartum depression and its associated impact on childhood developmental outcomes is the first necessary step in developing adequate treatment plans.

描述（由申请人提供）：该项目的目标是对 NIMH 使命的直接回答，即解决产后抑郁症的流行病学问题，识别相关风险因素并描述与临床显着的产后情绪变化相关的儿童发育和心理健康结果。产后抑郁症是最常见的生育并发症（Wisner KL、Chambers C、Sit D. 产后抑郁症：一个重大公共卫生问题。JAMA 2006~296:2616-2618），大约 11%-19% 的新妈妈有这种症状（证据报告/技术评估 119。AHRQ 出版物 05-E006-2）。迄今为止，大多数关于产后抑郁症的研究都依赖于来自诊所或医院的小型便利样本，这些样本无法生成规范数据，并利用不同的诊断标准，这些标准通常更侧重于抑郁症状学而不是抑郁症的临床诊断。 这项研究建立在瑞典现有的独特的心理健康研究资源的基础上。连接瑞典的一系列登记册，包括国家健康患者登记册和卫生服务利用情况、国家学校登记册、 通过国家药房登记、总人口登记和住房普查，我们将：(a) 通过更准确地描述临床上显着的产后抑郁症（住院和非住院）的程度和模式以及相关的风险因素，扩展现有的产后抑郁症流行病学知识库，以及〜 (b) 全面描述母亲产后抑郁症的儿童发育结果。 我们将利用先进的统计方法来确定产后抑郁症的发展后果，评估产后抑郁症母亲的孩子或多或少出现问题的可能性，无论是由母亲特征（如抑郁发生时间、严重程度、亚型（有或没有精神病）或合并症）、儿童特征（如性别）或背景因素（如贫困）来解释。 该研究的目标雄心勃勃，但我们已经建立了一支具有悠久合作历史的国际专家团队，非常适合实现该研究目标。出于预测目的，评估产后抑郁症的一系列潜在决定因素将产生新的见解，以帮助预测、识别并最终帮助预防和治疗这种疾病。由于婴儿出生后的时期是关键时期，而产后抑郁症对婴儿的健康构成严重威胁，因此临床上显着的产后抑郁症的流行病学特征及其对儿童发育结果的相关影响是制定适当治疗计划的第一个必要步骤。