Short-term outcomes of interventions for reproductive dysfunction

描述（由申请人提供）：是否通过手术矫正模糊的生殖器，使其更具女性特征或男性特征，是儿科医学中一个极具争议的领域。不理想的结果，如术后美容效果差和过时手术后的性功能障碍，在医学界引发了激烈的争议，即如何或是否应该使用生殖器成形术治疗生殖器模糊的幼儿。为了解决这一争论，需要对目前生殖器成形术的结果进行前瞻性研究，包括与这些手术相关的并发症发生率，研究对象是在儿童早期接受男性化或女性化手术的个体。此外，有必要对决定是否为孩子进行生殖器成形术的父母进行研究，以了解这些有争议的决定如何影响父母对孩子手术结果的反应。本提案的总体目标是评估现代生殖器成形术的结果，同时考虑到决定为孩子进行生殖器手术的父母的心理结果。这些信息是至关重要的

DESCRIPTION (provided by applicant): Whether or not to surgically correct ambiguous genitalia to be more female- or male-typical with genitoplasty is an area of pediatric medicine that is highly controversial. Suboptimal outcomes such as poor post-surgical cosmesis and sexual dysfunction following outdated surgical procedures have driven intense controversy in the medical community over how, or if, genitoplasty should be used in the treatment of young children with ambiguous genitalia. To resolve this debate, a prospective study of outcomes of current genitoplasty procedures, including complication rates associated with these procedures, is needed of individuals who receive masculinizing or feminizing surgery during early childhood. Additionally, studies of parents who decide to proceed, or not, with genitoplasty for their young child are necessary to understand how these controversial decisions impact parents' reactions to surgical outcomes for their child. The overall goal of this proposal is to assess the outcomes of modern genitoplasty techniques with a consideration of the psychological outcome of parents who make the decisions to proceed with genital surgery for their child. This information is crucial for physicians to provide guidance to parents regarding the optimal approach for the management of ambiguous genitalia in young children, including the possibility that no surgery is best. The interdisciplinary group of clinicians and researchers included in the proposed studies spans the fields of psychology, statistics, pediatric endocrinology, and pediatric urology. The collective experience of our group optimizes our ability to translate findings from the proposed studies to a clinical setting in a timely manner.