Short-term outcomes of interventions for reproductive dysfunction

生殖功能障碍干预措施的短期结果

• 批准号: 9473993
• 负责人: Larry L. Mullins
• 金额: $ 21.5万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-05 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9473993
• 关键词: Short; term; outcomes; interventions; reproductive

DESCRIPTION (provided by applicant): Whether or not to surgically correct ambiguous genitalia to be more female- or male-typical with genitoplasty is an area of pediatric medicine that is highly controversial. Suboptimal outcomes such as poor post-surgical cosmesis and sexual dysfunction following outdated surgical procedures have driven intense controversy in the medical community over how, or if, genitoplasty should be used in the treatment of young children with ambiguous genitalia. To resolve this debate, a prospective study of outcomes of current genitoplasty procedures, including complication rates associated with these procedures, is needed of individuals who receive masculinizing or feminizing surgery during early childhood. Additionally, studies of parents who decide to proceed, or not, with genitoplasty for their young child are necessary to understand how these controversial decisions impact parents' reactions to surgical outcomes for their child. The overall goal of this proposal is to assess the outcomes of modern genitoplasty techniques with a consideration of the psychological outcome of parents who make the decisions to proceed with genital surgery for their child. This information is crucial for physicians to provide guidance to parents regarding the optimal approach for the management of ambiguous genitalia in young children, including the possibility that no surgery is best. The interdisciplinary group of clinicians and researchers included in the proposed studies spans the fields of psychology, statistics, pediatric endocrinology, and pediatric urology. The collective experience of our group optimizes our ability to translate findings from the proposed studies to a clinical setting in a timely manner.

描述（由申请人提供）：是否通过外科手术矫正模棱两可的生殖器，使其更具有女性或男性特征，这是儿科医学中极具争议的一个领域。不理想的结果，如手术后美容效果差和过时的手术后性功能障碍，在医学界引发了激烈的争议，关于如何或是否应该使用生殖器成形术治疗生殖器模糊的幼儿。为了解决这一争论，需要对儿童早期接受男性化或女性化手术的个体进行一项前瞻性研究，以了解当前生殖器成形术的结果，包括与这些手术相关的并发症发生率。此外，有必要对决定是否为年幼的孩子进行生殖器成形术的父母进行研究，以了解这些有争议的决定如何影响父母对孩子手术结果的反应。该提案的总体目标是评估现代生殖器成形术的结果，同时考虑决定为孩子进行生殖器手术的父母的心理结果。这个信息至关重要 医生可以为父母提供指导，指导他们如何采取最佳方法来处理年幼儿童的不明生殖器，包括最好不要手术的可能性。建议研究中包括的临床医生和研究人员的跨学科小组跨越了心理学、统计学、儿科内分泌学和儿科泌尿学领域。 我们小组的集体经验优化了我们及时将拟议研究结果转化为临床环境的能力。