Workshop on Techniques in Modeling Human Cancer in Mice

项目总结/摘要 癌症是一组遗传上复杂且生物学上异质的疾病。已变得越来越 显然，实验室小鼠，最好的基因定义的人类实验模型生物， 为快速了解遗传基础和潜在生物学提供了一个重要的机会 癌症。我们课程的总体目标是“小鼠中人类癌症建模技术研讨会”， 培训一小批年轻科学家（博士前、博士后学员、新研究人员）使用 基因定义的实验室小鼠作为遗传工具，询问有关基因功能和作用的问题， 癌症生物学中的遗传学。完成本课程的学生将获得如何 表征和分析特定的小鼠癌症模型。选择的模型将反映几个器官部位 包括结肠、前列腺、乳腺、肺、皮肤、血液和脑。本课程将包括以下教学讲座： 上午介绍特定的器官部位和与这些器官相关的癌症的特征 网站，然后是密集的实验室会议，使学生将获得在实践中的经验， 相关小鼠模型的操作和分析。会议将包括固定和活细胞成像 技术、细胞计数、肿瘤植入的手术方法和病理学。 为实现这些目标，将为16名被选中的年轻调查员提供为期10天的强化课程， 他们杰出的研究潜力。他们将与一群杰出的老鼠遗传学家和癌症 来自杰克逊实验室和其他著名机构的生物学家。班级规模将保持不变 故意小，以实现学生与教师互动的理想水平，并允许广泛 学生的实验室培训和实践。该课程将于每年10月举行 在公海，杰克逊实验室的住宅海滨会议设施。讲座，讨论， 研讨会和演示将在上午，下午和晚上举行，共约72 小时的教学和实践培训。我们要求在此应用程序中提供整整五年的支持。 杰克逊实验室是一个国家癌症研究所指定的基础研究癌症中心，有着悠久的历史， 举办高级课程和科学会议。

PROJECT SUMMARY/ABSTRACT Cancer is a genetically complex and biologically heterogeneous group of disorders. It has become increasingly clear that the laboratory mouse, the best genetically defined experimental model organism for humans, presents a major opportunity for rapid advancement in understanding the genetic basis and underlying biology of cancer. The overall goal for our course, "Workshop on Techniques in Modeling Human Cancer in Mice", is to train a small group of young scientists (predoctoral, postdoctoral trainees, new investigators) in the use of genetically defined laboratory mice as genetic tools for asking questions about gene function and the role of genetics in the biology of cancer. Students completing the course will acquire a practical knowledge of how to characterize and analyze specific mouse cancer models. The models chosen will reflect several organ sites including colon, prostate, mammary, lung, skin, blood and brain. The course will consist of didactic lectures in the morning to introduce particular organ sites and the characteristics of cancers associated with those organ sites, followed by intensive laboratory sessions whereby students will gain hands on experience in the manipulation and analysis of relevant mouse models. Sessions will include fixed and live cell imaging techniques, cytometry, surgical approaches to the implantation of tumors, and pathology. These Aims will be accomplished by offering an intensive 10-day course to 16 young investigators chosen for their outstanding research potential. They will interact with a group of prominent mouse geneticists and cancer biologists both from The Jackson Laboratory and other prominent institutions. The size of the class will be kept deliberately small in order to achieve a desirable level of student-faculty interaction and to permit extensive laboratory training and practice for the students. The course will be held annually during the month of October at Highseas, The Jackson Laboratory's residential oceanfront conference facility. Lectures, discussions, workshops, and demonstrations will be held morning, afternoon, and evening for a total of approximately 72 hours of didactic and hands-on training. We are asking for a full five years of support in this application. The Jackson Laboratory is an NCI-designated Basic Research Cancer Center and has a long history of hosting advanced courses and scientific meetings.