Retroviral Evasion of Immune Response

逆转录病毒逃避免疫反应

• 批准号: 8372384
• 负责人: Tatyana V Golovkina
• 金额: $ 39.84万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-12-01 至 2016-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8372384
• 关键词: Acute; Adoption; Alprostadil; Animal Model; Antibiotics; Antibodies; BALB/cJ Mouse; Betaretrovirus; Blood; CD8B1 gene; Cessation of life; Complex; Data; Dendritic Cells; Development; Ensure; Family; Fc Receptor; Gammaretrovirus; Genes; Germ-Free; HIV; Histocompatibility; Human T-Cell Leukemia Viruses; Immune; Immune Tolerance; Immune response; Immune system; Immunity; Immunoglobulins; Immunologic Deficiency Syndromes; Immunosuppression; Immunosuppressive Agents; Infection; Interferons; Interleukin-10; Interleukin-6; Intestines; Knock-out; Lipopolysaccharides; Longevity; Lymphocyte; Macroglobulins; Major Histocompatibility Complex; Mediating; Milk; Molecular; Mouse Mammary Tumor Virus; Murine leukemia virus; Mus; Myelogenous; Natural Killer Cells; Neonatal; Newborn Infant; Oral; Organism; Pathway interactions; Pattern; Pattern recognition receptor; Process; Production; Property; Reporting; Retroviridae; Role; Route; Signal Pathway; Signal Transduction; Specific Pathogen Frees; Surface; T-Lymphocyte; TLR4 gene; Toll-like receptors; Viral; Viral Antigens; Virion; Virus; Virus Diseases; Virus Replication; arm; commensal microbes; cytokine; cytotoxic; gastrointestinal; germ free condition; human TLR7 protein; immune clearance; in vivo; intraperitoneal; killer T cell; macrophage; mammary tumor virus; neonatal Fc receptor; novel; offspring; oral tolerance; pathogen; response; toll-like receptor 4; trait; transmission process

DESCRIPTION (provided by applicant): We found that Muse Mammary Tumor Virus, a betaretrovirus spread through the milk, requires commensal microbiota for successful transmission. The virus exploits bacterially-produced lipopolysaccharide to elicit immunosuppressive cytokines and thus, counteract anti-virus immune response. Our studies will uncover the rules of retrovirus-microbiota-host interaction by using genetically defined and germ-free mice.

描述（由申请人提供）：我们发现Muse乳腺肿瘤病毒是一种通过乳汁传播的β逆转录病毒，需要肠道微生物群才能成功传播。该病毒利用细菌产生的脂多糖来引发免疫抑制细胞因子，从而抵消抗病毒免疫应答。我们的研究将揭示逆转录病毒-微生物群-宿主相互作用的规则，通过使用遗传定义和无菌小鼠。