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Stage II Research on Outpatient Treatment for Adolescents with Comorbidity

青少年合并症门诊治疗的第二阶段研究

基本信息

批准号：
8494016
负责人：
ASHLI J SHEIDOW
金额：
$ 5.64万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8494016
关键词：
Action Research Address Adherence Adolescent Alcohol or Other Drugs use Anxiety Back Behavior Behavior Therapy Behavioral Build-it Caregivers Clinical Clinical Trials Cognitive Communities Comorbidity Consumer Satisfaction Control Groups Data Data Collection Diagnostic Disease Drug usage Evaluation Exhibits Family Family psychotherapy Funding Individual Intervention Lead Manuals Measures Mediating Mental Depression Mental Health Modeling Moods National Institute of Drug Abuse Outcome Outpatients Parenting behavior Patient Self-Report Placebos Preclinical Drug Evaluation Principal Investigator Protocols documentation Psychiatric Diagnosis Randomized Randomized Clinical Trials Relative (related person)Reporting Research Research Personnel Schools Services Social Adjustment Societies Staging Symptoms System Techniques Testing Therapeutic TimeLine Training Treatment Efficacy Treatment outcome Urine Youth adolescent substance abuse base community based treatment control trial cost depressive symptoms design deviant dual diagnosis experience follow-up improved indexing peer pilot trial programs psychosocial quality assurance reduced substance use satisfaction therapy development treatment planning

项目摘要

PROJECT SUMMARY/ABSTRACT Adolescent substance abuse results in significant negative outcomes and extraordinary costs for youths, their families, communities, and society. Moreover, rates of psychiatric comorbidity among substance abusing youth range from 25% up to 82%, and youths with a dual diagnosis are more than twice as costly to treat compared to those with no comorbidity. Community-based treatment for these youth most often is disjointed, with youth and families having to navigate separate treatment systems for the disorders or only receiving treatment for a single disorder. Notably, multiple studies have shown that youth with co-occurring problems have worse outcomes and return to pre-treatment levels of substance use more often and more rapidly than those without a psychiatric diagnosis. The applicant principal investigator, a new investigator, recently completed a NIDA-funded Stage I project focused on developing and piloting a psychosocial treatment specifically for youth presenting for outpatient treatment with co-occurring substance use and internalizing (i.e., mood and/or anxiety) problems. Results were promising with the experimental group exhibiting significantly less substance use and more rapid reductions in anxiety and depressive symptoms compared to the control group. In addition, extensive treatment and therapist training manuals were generated. The proposed research is a Stage II randomized clinical trial (RCT) to compare the experimental treatment (OutPatient Treatment for Adolescents; OPT-A) to an "active placebo" on key clinical indices from pre-treatment through 18 months. The proposed RCT (n = 160) employs the treatment manual, quality assurance protocol, and therapist training protocol developed and successfully piloted in the Stage I study, to evaluate the efficacy of OPT-A for youth referred to outpatient treatment of co- occurring substance use and internalizing problems. The following outcomes will be evaluated: drug use; mental health; behavioral, school, peer, and family functioning; and consumer satisfaction. In addition to providing a strong test of treatment efficacy, the proposed project will leverage the data collection of the RCT to provide a preliminary evaluation of putative mechanisms of action. In summary, this study will advance a promising treatment developed through the Stage I behavioral therapies development program to a Stage II controlled trial. It builds on the treatment manual, therapist training materials, and quality assurance system already developed. The intervention addresses one of the more prevalent and most challenging, costly, and understudied presenting problems among adolescent outpatients. If successful, this research could provide a considerable contribution in the treatment field for youth with co-occurring substance use and internalizing disorders.

项目总结/文摘