Administrative Core

行政核心将支持杜克孢子在脑癌方面的总体目标， 是将基础研究成果迅速地转移到临床上，以便立即 对癌症死亡率和发病率的影响。为此，行政核心将培育和促进 基础和临床科学家在研究概念化和实施方面的合作 项目。它还将与杜克癌症研究所(DCI)的领导层密切合作，协调努力 在神经肿瘤学项目和孢子之间。这将最大限度地利用资源，通过 促进现有DCI核心设施的使用，并在进一步加强时在现有核心设施的基础上进行建设 都是必需的。它还将为人体组织的收集和维护提供行政支助。 将使整个社区受益的资源。最后，它将提供必要的基础设施来发展 与其他孢子和美国国立卫生研究院的长期合作。此核心整合了这些功能，以缓解 这不仅增加了调查人员的负担，而且还提供了规模经济和外部质量保证。 该核心的具体目标将是：1)提供组织、管理和科学 领导力，提供可信的研究成功范例，表现出对所有人的尊重和关心 团队成员，建立团队认同感和凝聚力，培养对创新和卓越的期望， 利用资源，提供建设性的反馈，并树立道德行为的榜样；2)提供 行政管理，监督资金分配并核算#年的所有支出 项目、核心、CDP和DRP，为手稿准备和NIH会议提供文书支持 出席，监督质量控制和产品发布，并确保财务和监管合规；3) 通过安排系列研讨会和其他活动，促进孢子和学会内部的整合 会议，利用机构支持，并在机构内外密切合作，以确保 优化利用资源和基础设施，消除重叠；4)维护和支持 通过提供组织基础设施来确保足够的癌症患者数量 研究对象和人体标本可用于开展本孢子中概述的项目；5) 通过确认数据共享以及定义和开发来开发能力并监督数据运营 与Core B协作的数据操作最佳实践，以确保可靠和有效的数据 以确保研究结果的数据完整性和可复制性的方式生成、管理和分析； 和6)通过测量研究进展并做出关于以下方面的决策来评估研究进展 通过每周会议、向EC和SC提交正式季度报告来延续或替换项目，以及 每半年向IAB或EAB和患者权益倡导者介绍一次。

The Administrative Core will support the general objectives of the Duke SPORE in Brain Cancer, which are to move basic research findings into the clinic in an expeditious fashion in order to have an immediate impact on cancer mortality and morbidity. To do this, the Administrative Core will cultivate and facilitate collaborations between basic and clinical scientists in the conceptualization and implementation of research projects. It will also work closely with the Duke Cancer Institute's (DCI) leadership to coordinate efforts between the Neuro-oncology program and the SPORE. This will maximize the utilization of resources by promoting use of existing DCI core facilities and building upon existing cores when additional enhancements are required. It will also provide administrative support for the collection and maintenance of human tissue resources that will benefit the entire community. Finally, it will provide necessary infrastructure to develop extended collaborations with other SPOREs and the NIH. This Core consolidates these functions to alleviate burdens on investigators, but also to provide economies of scale and external quality assurance. The Specific Aims of this Core will be: 1) To provide organizational, administrative, and scientific leadership by providing credible examples of research success, demonstrating respect and concern for all team members, building team identity and coherence, cultivating expectations of innovation and excellence, leveraging resources, providing constructive feedback, and modeling ethical behavior; 2) To provide administrative management by overseeing distribution of funds and accounting for all expenditures in Projects, Cores, CDP and DRP, providing clerical support for manuscript preparation and NIH meeting attendance, overseeing quality control and product release, and ensuring fiscal and regulatory compliance; 3) To promote integration within the SPORE and the Institution by scheduling seminar series and other meetings, leveraging institutional support and working closely within and outside our institution to ensure that resources and infrastructure are optimally utilized and overlaps eliminated.; 4) To maintain and support an adequate cancer patient population by providing an organizational infrastructure that assures adequate research subjects and human specimens are available to conduct the Projects outlined in this SPORE; 5) To develop capabilities and oversee data operations by confirming data sharing and defining and developing best practices for data operations in collaboration with Core B to ensure that reliable and valid data are generated, managed, and analyzed in a way that ensures data integrity and replicability of research findings; and 6) To evaluate research progress by measuring research progress and making decisions regarding project continuation or replacement through weekly meetings, formal quarterly reports to EC and SC, and semi-annual presentations to the IAB or EAB, and patient advocates.