Renovation for Animal Facility Safety & Long-Tern Support of Research at the Univ

动物设施安全改造

• 批准号: 8713008
• 负责人: Craig A Fletcher
• 金额: $ 45.88万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8713008
• 关键词: 20 year old; Accounting; Accreditation; Alcohols; Allergens; Animal Experimentation; Animal Housing; Animal Model; Animals; Area; Arthritis; Bacterial Genes; Beds; Behavioral; Biohazardous Substance; Biological; Biomedical Research; Breeding; Cancer Center; Carcinogens; Caring; Censuses; Chemicals; Communicable Diseases; Communities; Complex; Digestive System Disorders; Disease; Environment; Environmental Health; Environmental air flow; Equipment; Exposure to; Faculty; Funding; Future; Genetic; Genome; Germ-Free; Gnotobiotic; Goals; Grant; Home environment; House mice; Housing; Human Resources; Humidity; Injury; Institution; International; Malignant Neoplasms; Mus; Mutant Strains Mice; Nature; North Carolina; Pharmacy Schools; Physiological; Population; Process; Pulmonary Cystic Fibrosis; Rattus; Research; Research Personnel; Research Support; Resources; Rodent; Rodent Model; Safety; Science; Services; Side; Specific Pathogen Frees; System; Temperature; Tern; United States National Institutes of Health; Universities; Water; Work; animal care; animal facility; chemical allergen; design; ergonomics; exhaust; exposed human population; germ free condition; hazard; human disease; improved; innovation; medical schools; meetings; member; nanomedicine; novel; operation; pathogen; programs; repository; trait

DESCRIPTION: University of North Carolina at Chapel Hill (UNC) cares for approximately 38,000 cages of mice housed in 18 different facilities. UNC is one of 4 Mutant Mouse Regional Resource Centers (MMRRC) and now also houses the Complex Trait Consortium Collaborative Cross (CC) breeding program. These NIH sponsored programs serve as a major repository of mouse stocks and serve the world-wide genetics and biomedical research community identifying novel disease-modifying loci. In addition, UNC is home for the National Gnotobiotic Rodent Resource Center (NGRRC) which provides services on local, national and international levels to academic institutions and governmental programs. The Thurston-Bowles Building (TBB) animal facility houses animals for 24 faculty members from 11 different departments and centers in the School of Medicine including the following Centers: Lineberger Comprehensive Cancer (LCCC), Infectious Diseases, Digestive Diseases, Nanomedicine, Cystic Fibrosis/Pulmonary Research and Treatment, the Bowles Center for Alcohol Studies, Thurston Arthritis Research, Genome Sciences, plus the School of Pharmacy. The TBB animal facility was constructed to house primarily large-animal species. TBB is comprised of 100% specific pathogen free rodent populations. However, while the demand for rodent housing in Thurston has increased, and innovation in animal caging would allow increases in the numbers of cages this building could accommodate, this expansion has not been possible because of limitations imposed by the design of the cage wash area and the current limitations of existing equipment for processing this caging. Funds are sought in this proposal to renovate the cage wash in the Thurston-Bowles animal facility to allow the full potential of this facility to be realized. We wil attain our objective by pursuing the following three specific aims: 1. Replace the rack washers with two energy efficient high throughput cage and rack washers: Two Tecniplast GP 900 cage and utensil washers will be purchased and installed to optimize cleaning of cages and improve efficiency of cage processing significantly which will allow an increase in the number of barrier-housed animals to meet future needs. 2. Optimize and increase the animal space in the dirty side of cage wash: Renovations in the physical configuration of the cage wash area will be made to accommodate higher return cage numbers, increased processing of cages, and processing of cages from animals with experimental pathogens and biohazards under conditions which meet environmental health and safety standards. 3. Improve cage wash safety and modernize the HVAC and exhaust system in the cage wash facility: This will improve environmental conditions, and cage processing efficiency in the washroom, and reduce personnel exposure to injuries, allergens, and animal cage bedding hazards. The proposed renovations to TBB cage wash would support $24,301,730 ongoing, extramurally funded grants and $13,798,653 that are pending.

描述：北卡罗来纳大学教堂山分校(UNC)在18个不同的设施中照顾大约38,000只笼子里的老鼠。北卡罗来纳大学是4个突变小鼠区域资源中心(MMRRC)之一，现在还拥有复杂性状联盟合作杂交(CC)育种计划。这些由美国国立卫生研究院赞助的项目作为老鼠种群的主要储存库，为世界范围内的遗传学和生物医学研究社区识别新的疾病修饰基因提供服务。此外，北卡罗来纳州还是国家灵生啮齿动物资源中心(NGRRC)的所在地，该中心为学术机构和政府项目提供地方、国家和国际层面的服务。瑟斯顿-鲍尔斯大楼(TBB)动物设施容纳了来自医学院11个不同部门和中心的24名教职员工的动物，包括以下中心：Lineberger综合癌症(LCCC)、传染病、消化系统疾病、纳米医学、囊性纤维化/肺研究和治疗、鲍尔斯酒精研究中心、瑟斯顿关节炎研究、基因组科学以及药学院。TBB动物设施的建造主要是为了容纳大型动物物种。TBB由100%无特定病原体的啮齿动物种群组成。然而，尽管瑟斯顿对啮齿动物住房的需求有所增加，动物笼养的创新将使这座建筑可以容纳的笼子数量增加，但由于笼子洗涤区设计的限制以及目前处理这种笼子的现有设备的限制，这种扩展是不可能的。在这项提案中寻求资金来翻新瑟斯顿-鲍尔斯动物设施中的笼子洗涤器，以使该设施的全部潜力得以实现。我们将通过追求以下三个具体目标来实现我们的目标：1.用两个高能效的笼式和架式垫圈取代笼式垫圈：将购买和安装两台Tecniplast GP 900笼式和器皿垫圈，以优化笼子的清洁，显著提高笼子加工的效率，从而增加屏障动物的数量，以满足未来的需求。2.优化和增加洗笼脏区的动物空间：对洗笼区域的物理配置进行翻新，以适应更多的回笼数量，增加笼子的加工量，并在符合环境卫生和安全标准的条件下处理带有实验病原体和生物危害的动物的笼子。3.提高笼洗安全，并使笼洗设施的暖通空调和排气系统现代化：这将改善洗手间的环境条件和笼子处理效率，并减少人员接触到伤害、过敏原和动物笼养床上用品的危险。拟议的TBB笼子清洗翻修将支持24,301,730美元的正在进行的外部供资赠款和13,798,653美元的待决赠款。