Renovation for Animal Facility Safety & Long-Tern Support of Research at the Univ

动物设施安全改造

• 批准号: 8713008
• 负责人: Craig A Fletcher
• 金额: $ 45.88万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8713008
• 关键词: 20 year old; Accounting; Accreditation; Alcohols; Allergens; Animal Experimentation; Animal Housing; Animal Model; Animals; Area; Arthritis; Bacterial Genes; Beds; Behavioral; Biohazardous Substance; Biological; Biomedical Research; Breeding; Cancer Center; Carcinogens; Caring; Censuses; Chemicals; Communicable Diseases; Communities; Complex; Digestive System Disorders; Disease; Environment; Environmental Health; Environmental air flow; Equipment; Exposure to; Faculty; Funding; Future; Genetic; Genome; Germ-Free; Gnotobiotic; Goals; Grant; Home environment; House mice; Housing; Human Resources; Humidity; Injury; Institution; International; Malignant Neoplasms; Mus; Mutant Strains Mice; Nature; North Carolina; Pharmacy Schools; Physiological; Population; Process; Pulmonary Cystic Fibrosis; Rattus; Research; Research Personnel; Research Support; Resources; Rodent; Rodent Model; Safety; Science; Services; Side; Specific Pathogen Frees; System; Temperature; Tern; United States National Institutes of Health; Universities; Water; Work; animal care; animal facility; chemical allergen; design; ergonomics; exhaust; exposed human population; germ free condition; hazard; human disease; improved; innovation; medical schools; meetings; member; nanomedicine; novel; operation; pathogen; programs; repository; trait

DESCRIPTION: University of North Carolina at Chapel Hill (UNC) cares for approximately 38,000 cages of mice housed in 18 different facilities. UNC is one of 4 Mutant Mouse Regional Resource Centers (MMRRC) and now also houses the Complex Trait Consortium Collaborative Cross (CC) breeding program. These NIH sponsored programs serve as a major repository of mouse stocks and serve the world-wide genetics and biomedical research community identifying novel disease-modifying loci. In addition, UNC is home for the National Gnotobiotic Rodent Resource Center (NGRRC) which provides services on local, national and international levels to academic institutions and governmental programs. The Thurston-Bowles Building (TBB) animal facility houses animals for 24 faculty members from 11 different departments and centers in the School of Medicine including the following Centers: Lineberger Comprehensive Cancer (LCCC), Infectious Diseases, Digestive Diseases, Nanomedicine, Cystic Fibrosis/Pulmonary Research and Treatment, the Bowles Center for Alcohol Studies, Thurston Arthritis Research, Genome Sciences, plus the School of Pharmacy. The TBB animal facility was constructed to house primarily large-animal species. TBB is comprised of 100% specific pathogen free rodent populations. However, while the demand for rodent housing in Thurston has increased, and innovation in animal caging would allow increases in the numbers of cages this building could accommodate, this expansion has not been possible because of limitations imposed by the design of the cage wash area and the current limitations of existing equipment for processing this caging. Funds are sought in this proposal to renovate the cage wash in the Thurston-Bowles animal facility to allow the full potential of this facility to be realized. We wil attain our objective by pursuing the following three specific aims: 1. Replace the rack washers with two energy efficient high throughput cage and rack washers: Two Tecniplast GP 900 cage and utensil washers will be purchased and installed to optimize cleaning of cages and improve efficiency of cage processing significantly which will allow an increase in the number of barrier-housed animals to meet future needs. 2. Optimize and increase the animal space in the dirty side of cage wash: Renovations in the physical configuration of the cage wash area will be made to accommodate higher return cage numbers, increased processing of cages, and processing of cages from animals with experimental pathogens and biohazards under conditions which meet environmental health and safety standards. 3. Improve cage wash safety and modernize the HVAC and exhaust system in the cage wash facility: This will improve environmental conditions, and cage processing efficiency in the washroom, and reduce personnel exposure to injuries, allergens, and animal cage bedding hazards. The proposed renovations to TBB cage wash would support $24,301,730 ongoing, extramurally funded grants and $13,798,653 that are pending.

描述：位于查佩尔山的北卡罗来纳州大学（University of North Carolina）在18个不同的设施中饲养了大约38,000只老鼠。该中心是4个突变小鼠区域资源中心（MMRRC）之一，现在还设有复杂性状联盟协作杂交（CC）育种计划。这些NIH赞助的项目作为一个主要的小鼠储备库，并为世界范围内的遗传学和生物医学研究社区提供服务，以确定新的疾病修饰基因座。此外，它还是国家啮齿动物资源中心（NGRRC）的所在地，该中心为学术机构和政府项目提供地方，国家和国际层面的服务。瑟斯顿-鲍尔斯大楼（TBB）动物设施为来自医学院11个不同部门和中心的24名教职员工提供动物，包括以下中心：Lineberger综合癌症（LCCC），传染病，消化系统疾病，纳米医学，囊性纤维化/肺部研究和治疗，鲍尔斯酒精研究中心，瑟斯顿关节炎研究，基因组科学，以及药学院。TBB动物设施主要用于饲养大型动物。TBB由100%无特定病原体的啮齿动物种群组成。然而，尽管Thurston对啮齿动物住房的需求有所增加，并且动物笼舍的创新将允许增加该建筑物可容纳的笼舍数量，但由于笼舍清洗区设计的限制以及处理该笼舍的现有设备的当前限制，这种扩展是不可能的。本提案寻求资金来翻新Thurston-Bowles动物设施的笼子清洗，以充分发挥该设施的潜力。我们将通过以下三个具体目标来实现我们的目标：1.用两台高能效高通量笼和笼架清洗机取代笼架清洗机：将购买并安装两台Tecniplast GP 900笼和器具清洗机，以优化笼的清洁并显著提高笼处理效率，从而增加围栏饲养动物的数量，以满足未来需求。2.优化和增加笼清洗脏侧的动物空间：将对笼清洗区的物理配置进行改造，以适应更多的返回笼数量，增加笼的处理，并在符合环境卫生和安全标准的条件下处理来自实验病原体和生物危害动物的笼。3.提高笼舍清洗安全性，并对笼舍清洗设施中的HVAC和排气系统进行现代化改造：这将改善环境条件，提高清洗室的笼舍处理效率，并减少人员暴露于伤害、过敏原和动物笼舍垫料危害。拟议的TBB笼子清洗翻新将支持24 301 730美元的持续，壁外资助的赠款和13 798 653美元的悬而未决。