UNC BSL3 Core Facility

北卡罗来纳大学 BSL3 核心设施

• 批准号: 10795381
• 负责人: Craig A Fletcher
• 金额: $ 791.68万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10795381
• 关键词: Animals; Communicable Diseases; Communities; Containment; Core Facility; Coronavirus; Disease Progression; Equipment; Future; Gills; Goals; Growth; Health; Human; Image; Immune response; Infection; Infectious Diseases Research; Infrastructure; Institution; Laboratories; Laboratory Research; Learning; Pathogenesis; Pharmacy Schools; Public Health; Readiness; Research; Research Personnel; Research Project Grants; Schools; Technology; biosafety level 3 facility; design and construction; future pandemic; health care availability; instrumentation; medical schools; microbial; novel therapeutics; novel vaccines; pathogenic virus; programs; recruit; response; square foot; usability

PROJECT SUMMARY / ABSTRACT: The central goal of this project is to construct a 10,000 square feet biosafety level 3 (BSL3) research laboratory core facility to promote readiness to respond to future pandemics. Infectious diseases pose a severe and increasing threat to human health, especially in communities that lack access to health care. UNC programs will soon exceed current infrastructure capacity due to increase demand. A strategic review of our microbial pathogenesis and infectious disease community concluded that urgent action was essential to support the high containment programs. Among the barriers to the growth of research was a lack of access to critical technologies and animal space within the existing BSL3 laboratories. This transformative BSL3 core facility will allow UNC to expand to meet current and projected research needs in the UNC School of Medicine, School of Pharmacy, and Gillings School of Global Public Health. UNC has engaged multiple stakeholders across the research community to design and construct a centralized BSL3 suite to characterize the immune responses to coronavirus and other emerging viral pathogens and learn about what drives immune response, disease progression, and protection against future infection. The proposal will attain four objectives: 1. Design and construct a high containment facility to bring investigators working on emerging and re-emerging infections together; 2. Enable access to specialized instrumentation including aerobiology and imaging equipment for supporting high containment research; 3. Create institution-wide core space to allow recruitment of new investigators to the infectious disease research community by increasing usable laboratory space in the BSL3 facility and purchasing new equipment that will serve investigators within the many UNC centers, institutes, and departments and their nationwide collaborators; 4. Enhance UNC's ability to lead the rapid response generating new therapeutics and vaccines to save lives on a local, national, and even global level.

项目总结/摘要： 该项目的中心目标是建造一个10，000平方英尺的生物安全3级（BSL 3）研究实验室 核心基金，以促进对未来大流行病作出反应的准备。传染病是一种严重的， 对人类健康的威胁越来越大，特别是在缺乏医疗保健的社区。项目将 很快就会超过目前基础设施容量。我们的微生物战略审查 发病机制和传染病界的结论是，必须采取紧急行动， 遏制计划研究增长的障碍之一是缺乏获得关键技术的途径 和现有BSL 3实验室内的动物空间。这一变革性的BSL 3核心设施将使BSL能够 扩大，以满足当前和预计的研究需求，在医学院，药学院， Gillings全球公共卫生学院联合国开发计划署与研究界的多个利益相关者进行了接触 设计和构建一个集中的BSL 3套件，以表征对冠状病毒和其他病毒的免疫反应， 新出现的病毒病原体，了解是什么驱动免疫反应，疾病进展和保护 防止未来的感染该提案将实现四个目标：1.设计和建造一个高安全壳 设施，使调查人员对新出现和重新出现的感染一起工作; 2.使得能够访问 支持高密封性的专门仪器，包括空气生物学和成像设备 研究; 3.创造机构范围的核心空间，以便招募新的传染病研究人员 通过增加BSL 3设施的可用实验室空间和购买新设备， 这将服务于许多研究中心，研究所和部门及其全国范围内的研究人员 合作者; 4.加强卫生部领导快速反应的能力，产生新的治疗方法和疫苗， 在地方、国家、甚至全球范围内拯救生命。