UNC BSL3 Core Facility

北卡罗来纳大学 BSL3 核心设施

• 批准号: 10795381
• 负责人: Craig A Fletcher
• 金额: $ 791.68万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10795381
• 关键词: Animals; Communicable Diseases; Communities; Containment; Core Facility; Coronavirus; Disease Progression; Equipment; Future; Gills; Goals; Growth; Health; Human; Image; Immune response; Infection; Infectious Diseases Research; Infrastructure; Institution; Laboratories; Laboratory Research; Learning; Pathogenesis; Pharmacy Schools; Public Health; Readiness; Research; Research Personnel; Research Project Grants; Schools; Technology; biosafety level 3 facility; design and construction; future pandemic; health care availability; instrumentation; medical schools; microbial; novel therapeutics; novel vaccines; pathogenic virus; programs; recruit; response; square foot; usability

PROJECT SUMMARY / ABSTRACT: The central goal of this project is to construct a 10,000 square feet biosafety level 3 (BSL3) research laboratory core facility to promote readiness to respond to future pandemics. Infectious diseases pose a severe and increasing threat to human health, especially in communities that lack access to health care. UNC programs will soon exceed current infrastructure capacity due to increase demand. A strategic review of our microbial pathogenesis and infectious disease community concluded that urgent action was essential to support the high containment programs. Among the barriers to the growth of research was a lack of access to critical technologies and animal space within the existing BSL3 laboratories. This transformative BSL3 core facility will allow UNC to expand to meet current and projected research needs in the UNC School of Medicine, School of Pharmacy, and Gillings School of Global Public Health. UNC has engaged multiple stakeholders across the research community to design and construct a centralized BSL3 suite to characterize the immune responses to coronavirus and other emerging viral pathogens and learn about what drives immune response, disease progression, and protection against future infection. The proposal will attain four objectives: 1. Design and construct a high containment facility to bring investigators working on emerging and re-emerging infections together; 2. Enable access to specialized instrumentation including aerobiology and imaging equipment for supporting high containment research; 3. Create institution-wide core space to allow recruitment of new investigators to the infectious disease research community by increasing usable laboratory space in the BSL3 facility and purchasing new equipment that will serve investigators within the many UNC centers, institutes, and departments and their nationwide collaborators; 4. Enhance UNC's ability to lead the rapid response generating new therapeutics and vaccines to save lives on a local, national, and even global level.

项目摘要/摘要： 该项目的中心目标是建设一个10,000平方英尺的生物安全3级(BSL3)研究实验室 促进做好应对未来大流行准备的核心设施。传染病构成了严重和 对人类健康的威胁越来越大，特别是在缺乏医疗保健的社区。北卡罗来纳大学的计划将 由于需求增加，很快就会超过目前的基础设施容量。对我们的微生物的战略回顾 致病机制和传染病社区得出结论，采取紧急行动对支持高 遏制计划。阻碍研究增长的障碍之一是缺乏关键技术 以及现有BSL3实验室内的动物空间。这一变革性的BSL3核心设施将使北卡罗来纳大学能够 扩展以满足北卡罗来纳大学医学院、药学院和 吉林斯全球公共卫生学院。北卡罗来纳大学与整个研究社区的多个利益相关者进行了接触 设计和构建一套集中的BSL3套件，以表征对冠状病毒和其他 新出现的病毒病原体，并了解驱动免疫反应、疾病进展和保护的因素 预防未来的感染。该提案将实现四个目标：1.设计和建造高安全壳 将致力于研究新发和再次出现的感染的调查人员聚集在一起的设施；2.允许访问 支持高密封性的专门仪器，包括空气生物学和成像设备 研究；3.创建机构范围的核心空间，以便招募新的传染病研究人员 通过增加BSL3设施中的可用实验室空间和购买新设备来研究社区 这将为北卡罗来纳大学的许多中心、研究所和部门及其全国范围内的调查人员提供服务 合作者；4.增强北卡罗来纳大学领导快速反应产生新疗法和疫苗的能力 在地方、国家甚至全球层面上拯救生命。