UNC BSL3 Core Facility

北卡罗来纳大学 BSL3 核心设施

• 批准号: 10795381
• 负责人: Craig A Fletcher
• 金额: $ 791.68万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10795381
• 关键词: Animals; Communicable Diseases; Communities; Containment; Core Facility; Coronavirus; Disease Progression; Equipment; Future; Gills; Goals; Growth; Health; Human; Image; Immune response; Infection; Infectious Diseases Research; Infrastructure; Institution; Laboratories; Laboratory Research; Learning; Pathogenesis; Pharmacy Schools; Public Health; Readiness; Research; Research Personnel; Research Project Grants; Schools; Technology; biosafety level 3 facility; design and construction; future pandemic; health care availability; instrumentation; medical schools; microbial; novel therapeutics; novel vaccines; pathogenic virus; programs; recruit; response; square foot; usability

PROJECT SUMMARY / ABSTRACT: The central goal of this project is to construct a 10,000 square feet biosafety level 3 (BSL3) research laboratory core facility to promote readiness to respond to future pandemics. Infectious diseases pose a severe and increasing threat to human health, especially in communities that lack access to health care. UNC programs will soon exceed current infrastructure capacity due to increase demand. A strategic review of our microbial pathogenesis and infectious disease community concluded that urgent action was essential to support the high containment programs. Among the barriers to the growth of research was a lack of access to critical technologies and animal space within the existing BSL3 laboratories. This transformative BSL3 core facility will allow UNC to expand to meet current and projected research needs in the UNC School of Medicine, School of Pharmacy, and Gillings School of Global Public Health. UNC has engaged multiple stakeholders across the research community to design and construct a centralized BSL3 suite to characterize the immune responses to coronavirus and other emerging viral pathogens and learn about what drives immune response, disease progression, and protection against future infection. The proposal will attain four objectives: 1. Design and construct a high containment facility to bring investigators working on emerging and re-emerging infections together; 2. Enable access to specialized instrumentation including aerobiology and imaging equipment for supporting high containment research; 3. Create institution-wide core space to allow recruitment of new investigators to the infectious disease research community by increasing usable laboratory space in the BSL3 facility and purchasing new equipment that will serve investigators within the many UNC centers, institutes, and departments and their nationwide collaborators; 4. Enhance UNC's ability to lead the rapid response generating new therapeutics and vaccines to save lives on a local, national, and even global level.

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