Study of Hyperkyphosis, Exercise and Function - SHEAF

后凸畸形、运动和功能的研究 - SHEAF

基本信息

批准号：
8721307
负责人：
WENDY Beth KATZMAN
金额：
$ 51.07万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-30 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8721307
关键词：
Address Adult Affect Age Aging American Autacoids Biometry Body Composition Chest Clinical Cohort Studies Communities Control Groups Data Data Analyses Discipline Early Intervention Elderly Evidence based treatment Exercise Exercise stress test Fatty acid glycerol esters Frail Elderly Funding Gait Geriatrics Goals Health Health Benefit Hyperkyphosis Impairment Individual Infiltration Institutes Intervention Intervention Trial Kyphosis deformity of spine Lateral Lower Extremity Measurement Measures Mediating Medicine Monitor Muscle Muscle Weakness Muscle function Musculoskeletal Osteoporosis Outcome Outcome Measure Participant Pathway interactions Patients Performance Persons Physical Function Physical therapy Physicians Placebos Posture Prevention strategy Public Health Randomized Controlled Trials Research Risk Risk Factors SF-36 Societies Speed Spinal Spinal Fractures Stretching Testing Time United States National Institutes of Health Upper Extremity Fracture Vertebral column Walking Woman Work X-Ray Computed Tomography actigraphy aged aging population bisphosphonate computerized density design disability effective intervention experience falls functional decline functional disability health related quality of life improved intervention effect men mortality muscle strength neglect older women performance tests physical conditioning physical functional ability prevent primary outcome programs prospective scoliosis secondary outcome standard of care success therapy development treatment strategy trial comparing

项目摘要

DESCRIPTION (provided by applicant): Hyperkyphosis is an accentuated forward thoracic curvature that is an independent risk factor for impaired physical function, reduced quality of lif, and other serious adverse health consequences. Although hyperkyphosis commonly affects older individuals, there are currently no evidence-based treatments to prevent or treat it. However, there is strong preliminary evidence that kyphosis-specific strengthening exercises done regularly over a three month period can improve kyphosis and physical function in older hyperkyphotic persons. Therefore, to build upon these preliminary findings, we now propose to conduct a randomized, controlled trial among 100 men and women aged 60 or older with hyperkyphosis to test if an exercise intervention that includes kyphosis-specific spinal muscle strengthening exercises compared to a non-specific stretching control will improve kyphosis and physical function assessed by the modified Physical Performance Test and gait speed. We will also assess whether the exercise intervention improves secondary measures of physical function and health related quality of life. Finally, to gain a better understanding of the mechanisms by which kyphosis-specific exercises may affect kyphosis and physical function, we will specifically measure spinal muscle strength via the Biodex and perform CT scan measurements of spinal muscle density to assess how muscle changes may mediate the effects of change in kyphosis on physical function. To date, exercise trials have used lower extremity strengthening exercise to improve physical function in older adults with demonstrated success, but none have targeted spinal strengthening, per se. Our specific focus on decreasing spinal hyperkyphosis represents a fundamental paradigm shift in exercise intervention strategies. This proposal is timely as the number of affected persons with hyperkyphosis is projected to increase with the aging population and currently, there are no standard prevention or treatment strategies to offer these patients. To address this important health problem and the National Institute of Aging's objective of maintaining physical functional ability in older persons, we have assembled an experienced team that includes experts in the design and conduct of randomized controlled trials, musculoskeletal medicine and physical therapy, geriatrics and biostatistics - a truly collaborative effort across multiple disciplines of expertise.

描述（由申请人提供）：高温性是一种突出的前向胸腔曲率，是身体机能受损，LIF质量降低以及其他严重不良健康后果的独立危险因素。尽管高温通常会影响老年人，但目前尚无基于证据的治疗方法来预防或治疗。然而，有强有力的初步证据表明，在三个月内定期进行的脑盲特定的增强练习可以改善老年高骨者的脑膜病和身体机能。因此，为了基于这些初步发现，我们现在建议对100名60岁或超年龄的男女进行随机，对照试验，以测试包括运动干预是否在内的运动干预措施是否与非特异性的伸展控制相比，与改良的身体表现和身体功能相比，是否包括脑脊柱特异性的脊柱肌肉增强运动，并通过改良的身体表现速度进行了改进的身体功能。我们还将评估运动干预是否改善了身体机能和与健康相关的生活质量的次要措施。最后，为了更好地理解脑膜病特异性锻炼可能影响脑膜病和身体功能的机制，我们将通过Biodex特异性地测量脊柱肌肉强度，并进行CT扫描测量的脊柱肌肉密度测量，以评估肌肉变化如何介导Kyphphosis对身体功能的影响可能介导对身体功能的影响。迄今为止，运动试验已使用下肢加强运动来改善其成功的老年人的身体机能，但没有一个针对脊柱加强。我们对减少脊柱高温的特定关注是运动干预策略的基本范式转变。该建议是及时的，因为预计患有高温的受影响的人的数量会随着老龄化的年龄而增加，目前，没有标准的预防或治疗策略来提供这些患者。为了解决这一重要的健康问题以及国家老化研究所保持老年人的身体功能能力的目标，我们组建了一个经验丰富的团队，其中包括在随机对照试验的设计和行为方面的专家，骨骼骨骼医学和物理疗法，老年人和生物统计学 - 真正的跨多个专业知识学科的合作。