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2/2-A Randomized Trial of Internet-Based Interventions for Bipolar Disorder

2/2-基于互联网的躁郁症干预随机试验

基本信息

批准号：
8489341
负责人：
Trisha Suppes
金额：
$ 20.85万
依托单位：
PALO ALTO VETERANS INSTIT FOR RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-20 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8489341
关键词：
21 year old Adherence Area Australia Bipolar Disorder Characteristics Chronic Clinical Collaborations Comprehension Computers Data Development Diagnosis Disease Doctor of Philosophy Education Effectiveness Effectiveness of Interventions Electronic Mail Elements Emergency Care Enrollment Evolution Exclusion Exposure to Future Geographic Locations Goals Health Health Services Accessibility Healthcare Healthcare Systems Hour Individual Information Technology Institutes International Internet Intervention Interview Leadership Learning Link Manic Measures Mental Depression Mental disorders Monitor Montgomery and Asberg depression rating scale Moods Online Systems Outcome Participant Patient Self-Report Patients Persons Pharmaceutical Preparations Population Primary Health Care Problem Solving Provider Proxy Psychosocial Assessment and Care Quality of life Randomized Recruitment Activity Recurrence Relapse Research Research Infrastructure Research Personnel Resources Running Silicones Site Social Welfare Social support Source Symptoms System Techniques Telephone Testing Time Training Universities Visit Voluntary Programs arm base blind cohort cost depressive symptoms design disorder later incidence prevention evidence base experience flexibility health care service utilization improved inclusion criteria interest medical schools medication compliance meetings member motivational enhancement therapy operation peer prevent primary outcome programs psychoeducation psychoeducational psychologic psychosocial psychotic symptoms randomized trial regional difference satisfaction self help therapy development tool trafficking web site

项目摘要

DESCRIPTION (provided by applicant): Psychosocial treatments are efficacious adjunctive treatments for persons with bipolar disorder. The use of internet platforms to deliver education and support for psychiatric disorders is increasingly common, but there is limited systematic research on the benefits of such programs. Internet based interventions have the potential to offer unlimited supportive resources with immediate access, minimal cost, convenience and flexibility. MoodSwings 2.0 is the next evolution of an internet-based intervention for individuals with bipolar disorder (www.moodswings.net.au), and is based on a validated face-to-face intervention, the MAPS project, which includes elements of psychosocial interventions including CBT, IPSTRT, psychoeducation, motivational interviewing, problem solving, goal setting, early warning signs and relapse prevention plans. Modules of MoodSwings 2.0 include symptom and disorder information as well as an asynchronous moderated peer discussion board. The program includes many interactive tools to optimize comprehension and retention of module content. MoodSwings 2.0 represents a significant improvement to earlier beta tested versions, with an improved platform, increased user navigation and interactive tools, and additional features designed to facilitate greater interest and interaction with program content. The program is not intended to serve as primary care for individuals with bipolar disorders. The proposed study includes the revision of MoodSwings 2.0, and a 12-month assessment of its use and benefits in patients with bipolar disorder. We propose a 2-site, 3-arm randomized parallel group stepped design (exposure to moderated peer discussion board only, discussion board plus psychoeducation, or discussion board, psychoeducation, and online interactive psychosocial tools). The collaborative sites (Palo Alto, CA and Melbourne, Australia) will enroll 300 participants with SCID-confirmed diagnoses of bipolar disorder I, II, or NOS. Interaction with research staff will occur through phone interviews and email correspondence, as participants will be recruited from any geographic location, providing inclusion criteria are met of a bipolar diagnosis, age 21-65, computer access, and local health care consisting of at least 2 provider visits in the past year and local emergency care. Exclusions are limited to current manic or psychotic symptoms. Utilization of the online MoodSwings 2.0 program is voluntary, and the program captures time spent in each content area over 12 months as an outcome of interest. Outcomes are assessed at quarterly intervals via phone interview with raters blind to group assignment as well as online self report. The primary outcome is the change in depressive symptoms over 12 months, assessing if there is additive benefit to the three components (education, discussion board, and interactive psychosocial tools) on improvement. Exploratory aims include symptoms of elevated mood, health services utilization, evidence of relapse (time to intervention), function, quality of life and medication adherence.

描述（由申请人提供）：社会心理治疗是双相情感障碍患者的有效辅助治疗。使用互联网平台为精神疾病提供教育和支持越来越普遍，但对此类计划的益处的系统研究有限。基于互联网的干预措施有可能提供无限的支持性资源，可以立即获得，费用最低，方便和灵活。MoodSwings 2.0是基于互联网的双相情感障碍个体干预的下一个演变（www.moodswings.net.au），并基于经过验证的面对面干预，MAPS项目，其中包括心理社会干预的要素，包括CBT，IPSTRT，心理教育，动机访谈，解决问题，目标设定，早期预警信号和复发预防计划。 MoodSwings 2.0的模块包括症状和障碍信息以及异步主持的同行讨论板。该计划包括许多互动工具，以优化模块内容的理解和保留。MoodSwings 2.0代表了对早期beta测试版本的重大改进，改进了平台，增加了用户导航和交互工具，以及旨在促进更大兴趣和与程序内容互动的其他功能。该计划不旨在作为双相情感障碍患者的初级护理。这项拟议的研究包括修订MoodSwings 2.0，并对其在双相情感障碍患者中的使用和益处进行为期12个月的评估。我们提出了一个2点，3臂随机平行组阶梯设计（暴露于主持同行讨论板，讨论板加心理教育，或讨论板，心理教育，和在线互动心理社会工具）。合作研究中心（加利福尼亚州帕洛阿尔托和澳大利亚墨尔本）将招募300名经SCID确认诊断为双相情感障碍I、II或NOS的参与者。与研究人员的互动将通过电话访谈和电子邮件通信进行，因为参与者将从任何地理位置招募，前提是符合双相障碍诊断、年龄21-65岁、计算机访问和当地医疗保健（包括过去一年至少2次提供者访视和当地紧急护理）的入选标准。排除仅限于当前的躁狂或精神病症状。使用在线MoodSwings 2.0计划是自愿的，该计划将12个月内在每个内容领域花费的时间作为感兴趣的结果。每季度通过电话访谈评估结果，评估者不知道小组分配情况，也不知道在线自我报告。主要结果是12个月内抑郁症状的变化，评估三个组成部分（教育，讨论板和交互式心理社会工具）对改善是否有额外的好处。探索性目标包括情绪升高的症状、卫生服务利用、复发证据（干预时间）、功能、生活质量和药物依从性。