BDNF Polymorphism and TBS on Practice Dependent Plasticity in Lower Limb

BDNF 多态性和 TBS 对下肢实践依赖性可塑性的影响

• 批准号: 8854041
• 负责人: Maxwell Boakye
• 金额: --
• 依托单位: VETERANS ADMIN PALO ALTO HEALTH CARE SYS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8854041
• 关键词: Affect; American; Ankle; Behavior; Behavioral; Brain; Codon Nucleotides; Development; Direct Costs; Effectiveness; Future; Gait; Genes; Genetic Polymorphism; Genotype; Goals; Growth Factor Gene; Healthcare Systems; Impairment; Individual; Injury; Iraq; Knowledge; Learning; Life; Long-Term Potentiation; Lower Extremity; Magnetism; Measures; Mediating; Medical; Methionine; Modeling; Motor; Motor Evoked Potentials; Movement; Muscle; Nerve Growth Factors; Neuraxis; Output; Patients; Performance; Recovery; Rehabilitation Outcome; Rehabilitation therapy; Residual state; Societies; Spinal cord injury; Spinal cord injury patients; Structure; Task Performances; Therapeutic; Training; United States; Valine; Veterans; War; abstracting; disability; healthy volunteer; improved; motor impairment; motor learning; motor skill learning; neurological recovery; preconditioning; socioeconomics; theories; tibialis anterior muscle; valylvaline; visual motor

DESCRIPTION (provided by applicant): Project Summary/Abstract There are over 10,000 new cases of SCI each year in the USA. The direct cost to society is over $8 billion each year. Despite best maximal therapy, recovery is limited with most patients having severe impairment and disability. The long-term goal of this project is to investigate the effectiveness of magnetic brain stimulation to augment behavioral gains after motor training in SCI patients. We have developed a model of activity dependent plasticity of the motor lower limb that will be used to study the effects of magnetic brain stimulation on the learning of a skilled motor task. Using this model we plan to examine two potential critical influences on the effect of brain stimulation on task learning. First we will evaluate the effects of homeostatic metaplasticity which refers to the impact a prior induction of plasticity has on the development of additional plasticity. Metaplasticity theory suggests that the effects of rehabilitation may be augmented if cortical plasticity is first reduced or downregulated using magnetic brain stimulation prior to motor training. Second we will evaluate the effects of Val66met polymorphisms involving a substitution of methionine for valine at codon 66 of the brain derived nerve growth factor (BDNF) gene. Recent studies indicate that activity dependent plasticity and homeostatic metaplasticity are significantly reduced in individuals with the Val66Met BDNF polymorphism. Therefore we plan to evaluate the effects priming inhibitory or excitatory magnetic brain stimulation has on skilled motor learning in the lower limb in healthy volunteers and in SCI patients. It is hoped that the results of this study will open up new vistas of understanding and therapeutic opportunities for rehabilitation of SCI individuals. Of the estimated 250,000 patients living in the United States with spinal cord injury, approximately 25% of these are Veterans. This number is likely to increase in the near future as a result of the Iraq war injuries. By including veterans with spinal cord injury in this study the results will be directly relevant to the large number of Veterans with spinal cord injury.

描述（由申请人提供）：