PS09-007 Evaluating Locally-Developed Homegrown HIV Prevention Interventions

PS09-007 评估当地开发的本土艾滋病毒预防干预措施

• 批准号: 8464582
• 负责人: EKOW KWA SEY
• 金额: $ 55.97万
• 依托单位: LOS ANGELES COUNTY PUBLIC HEALTH DEPARTMENT
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8464582
• 关键词: PS09; 007; Evaluating; Locally; Developed

DESCRIPTION (provided by applicant): Data on HIV cases reported in 33 U.S. states with HIV reporting indicate the burden of HIV/AIDS is most concentrated in the African American population compared to other racial/ethnic groups. Of the 49,704 African American males diagnosed with HIV between 2001 and 2004, 54% of these cases were among men who have sex with men (MSM). In Los Angeles County (LAC), the proportion of HIV/AIDS cases among African American males attributable to male-to-male sexual transmission is even greater (75%). In the absence of an effective vaccine, behavioral interventions represent one of the few methods for reducing high HIV incidence rates among African American MSM (AAMSM). While a number of individual- and group-level HIV interventions have been created by and for a variety of AAMSM organizations across the U.S., evaluation data to document the effectiveness of these programs are practically non-existent. Given the conspicuous absence of both 1) evidence-based HIV interventions and 2) "best practices" outcome evaluations of existing AAMSM programs, our collaborative team intends to address a glaring research gap by implementing a scientifically rigorous evaluation of an insufficiently evaluated "homegrown" HIV prevention program developed for AAMSM ages 18-29 years. This application responds directly to the funding opportunity announcement RFA-PS-09-007 by proposing a systematic program evaluation of In The Meantime Men's Group's (ITMT) locally developed "MyLife MyStyle" small-group intervention. MyLife MyStyle was designed by AAMSM in Los Angeles County in 2005-2006 to address the crucial HIV prevention needs of 18- to 29-year-old AAMSM, a population experiencing the highest rate of HIV incidence in the U.S. In the MyLife MyStyle Evaluation Project, the collaborative team will test the hypothesis that participants of the MyLife MyStyle program will report at least a 15% absolute decrease in frequency of unprotected anal sex with male partners at three months post-intervention. To test our research hypothesis and to understand critical elements of an intervention designed for young AAMSM at risk of HIV acquisition and transmission, we have identified the following Specific Aims for the 5-year project period: 1) Implement a randomized controlled trial for a minimum of 300 AAMSM, ages 18-29 years, to test the effectiveness of MyLife MyStyle to reduce unprotected anal sex (UAS) with male partners at three months post-intervention compared to a wait-list control condition; 2) Conduct a comprehensive program evaluation to identify intervention elements associated with program success, such as: a) intervention components, processes, and characteristics; b) recruitment and retention strategies; c) requirements of the organization's infrastructure necessary to deliver the intervention; and d) a cost-effectiveness analysis.

描述（由申请人提供）：美国 33 个有艾滋病毒报告的州报​​告的艾滋病毒病例数据表明，与其他种族/族裔群体相比，艾滋病毒/艾滋病的负担最集中于非裔美国人。 2001 年至 2004 年间，有 49,704 名非洲裔美国男性被诊断出感染艾滋病毒，其中 54% 是男男性行为者 (MSM)。 在洛杉矶县 (LAC)，非裔美国男性中通过男性间性传播感染艾滋病毒/艾滋病的比例更高 (75%)。 在缺乏有效疫苗的情况下，行为干预是降低非裔美国人 MSM (AAMSM) 中艾滋病毒高发病率的少数方法之一。 尽管美国各地的 AAMSM 组织已经制定了许多个人和团体层面的艾滋病毒干预措施，但记录这些计划有效性的评估数据实际上不存在。 鉴于现有 AAMSM 项目明显缺乏 1) 基于证据的艾滋病毒干预措施和 2) “最佳实践”结果评估，我们的合作团队打算通过对针对 18-29 岁 AAMSM 开发的未经充分评估的“本土”艾滋病毒预防项目进行科学严格的评估，来解决明显的研究差距。 该申请直接响应资助机会公告 RFA-PS-09-007，提出对 In The Meantime Men's Group (ITMT) 当地开发的“MyLife MyStyle”小组干预进行系统计划评估。 MyLife MyStyle 是由洛杉矶县的 AAMSM 于 2005 年至 2006 年设计的，旨在满足 18 至 29 岁 AAMSM 的关键艾滋病毒预防需求，该人群是美国艾滋病毒发病率最高的人群。在 MyLife MyStyle 评估项目中，合作团队将测试这样的假设：MyLife MyStyle 计划的参与者将报告艾滋病毒发生频率绝对下降至少 15%。 干预后三个月与男性伴侣进行无保护的肛交。 为了检验我们的研究假设并了解为面临 HIV 感染和传播风险的年轻 AAMSM 设计的干预措施的关键要素，我们确定了 5 年项目期间的以下具体目标： 1) 对至少 300 名 18-29 岁的 AAMSM 实施随机对照试验，以测试 MyLife MyStyle 在干预后三个月减少与男性伴侣无保护肛交 (UAS) 的有效性，与 等候名单控制条件； 2) 进行全面的计划评估，以确定与计划成功相关的干预要素，例如： a) 干预组成部分、过程和特征； b) 招聘和保留策略； c) 实施干预所需的组织基础设施的要求； d) 成本效益分析。