2014 International Motoneuron Society Meeting

2014年国际运动神经元学会会议

• 批准号: 8715497
• 负责人: MARC D BINDER
• 金额: $ 1.2万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8715497
• 关键词: Address; Animal Model; Animals; Australia; Basic Science; Behavior; Canada; Cell physiology; Clinical; Communication; Computer Simulation; Data; Development; Disease; Europe; Exercise; Fatigue; Financial Support; Fostering; Goals; Heart; Human; International; Investigation; Laboratories; Modeling; Motor; Motor Neurons; National Institute of Neurological Disorders and Stroke; North America; Nova Scotia; Paris, France; Parkinson Disease; Pathology; Pattern; Postdoctoral Fellow; Research Personnel; Schedule; Scientist; Series; Societies; Specialist; Speed; Spinal Injuries; Spinal cord injury; Stroke; System; Therapeutic; Time; Translating; Video Recording; Work; abstracting; design; graduate student; hemiparetic stroke; human subject; meetings; novel therapeutics; public health relevance; symposium; web site

DESCRIPTION (provided by applicant): We are seeking financial support for PIs, post-doctoral fellows and graduate students working in US laboratories planning to participate in the 9th Meeting of the International Motoneuron Society scheduled for June 2014. The goal of these highly successful, international meetings is to bring investigators working on motoneurons and motor units in animal models together with those performing analogous studies on human subjects. A major emphasis of the discussions is on translating basic science advances into clinical therapies. This field is unusually international, with the key laboratories scattered throughout North America, Europe and Australia. Thus, these meetings have been essential for maintaining communication and progress in the field, and they have fostered a number of important collaborative projects. NINDS has generously supported several of the prior meetings in this series (Boulder, 2000; Boulder, 2004; Seattle, 2008, Paris, 2010 and Sydney, 2012). To facilitate interactions between the participating labs at the meeting, each session consists of an introduction for non-specialists, short presentations, and extended time for discussion. Each session will have at least one presentation by a post-doctoral fellow or a graduate student. Sessions on cellular physiology from animal models are interspersed with related studies on human subjects throughout the meeting. We also include discussions of recent developments in high speed, biologically realistic computer simulations that potentially provide a platform for quantitatively relating these two types of data. The issue at the heart of the meeting is how can the experimental results and computer simulations be best integrated to resolve the cellular mechanisms underlying motor unit firing patterns both in normal function (fatigue, exercise) and in disease states (spinal injury, hemiparetic stroke, ALS and SMA). A new addition at this meeting will be the inclusion of clinician-scientists who will address therapeutic approaches to motor pathologies. The abstracts submitted by each invited speaker will be posted on a publicized website. Following the meeting, video recordings of the talks and discussion sessions will be uploaded to the expanded website. We anticipate that this will generate new ideas and approaches for investigation of motor systems as well as creation of new therapeutic strategies for spasticity in spinal injury and stroke and motoneuron degeneration in ALS and SMA.

描述（由申请人提供）：我们正在寻求财政支持的PI，博士后研究员和研究生在美国实验室工作计划参加国际运动神经元学会定于2014年6月第9次会议。这些非常成功的国际会议的目标是将研究动物模型中运动神经元和运动单位的研究人员与对人类受试者进行类似研究的研究人员聚集在一起。讨论的一个主要重点是将基础科学进展转化为临床治疗。这个领域是非常国际化的，重点实验室分布在北美，欧洲和澳大利亚。因此，这些会议对于保持实地的沟通和进展至关重要，并促成了一些重要的合作项目。NINDS慷慨地支持了该系列的前几次会议（博尔德，2000年;博尔德，2004年;西雅图，2008年;巴黎，2010年和悉尼，2012年）。 为了促进与会实验室之间在会议上的互动，每个会议都包括对非专业人员的介绍、简短的演讲和延长的讨论时间。每节课将至少有一个博士后研究员或研究生的演讲。在整个会议期间，关于动物模型的细胞生理学的会议穿插着关于人类主题的相关研究。我们还讨论了高速，生物逼真的计算机模拟，可能提供一个平台，定量相关的这两种类型的数据的最新发展。会议的核心问题是如何最好地整合实验结果和计算机模拟，以解决正常功能（疲劳，运动）和疾病状态（脊髓损伤，轻偏瘫中风，ALS和SMA）中运动单位放电模式的细胞机制。本次会议的一个新的补充将是包括临床科学家谁将解决运动病理学的治疗方法。每位受邀发言者提交的摘要将张贴在一个公开网站上。会后，讲座及讨论会的录像将上载至扩大后的网站。我们预计，这将产生新的想法和方法的运动系统的调查，以及创造新的治疗策略，痉挛的脊髓损伤和中风和运动神经元变性的ALS和SMA。