International Meeting on Plasticity and Disease of Motoneurons

运动神经元可塑性和疾病国际会议

• 批准号: 7483543
• 负责人: MARC D BINDER
• 金额: $ 1万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7483543
• 关键词: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Arts; Behavior; Cells; Computer Simulation; Data; Development; Disease; Exercise; Fatigue; Fire - disasters; Heart; International; Investigation; Measures; Motor; Motor Neurons; Muscle Fibers; Pattern; Plastics; Postdoctoral Fellow; Preparation; Public Health; Specialist; Speed; Spinal Injuries; Stroke; Students; System; Time; abstracting; day; design; hemiparetic stroke; human data; human subject; novel therapeutics; simulation; symposium

DESCRIPTION (provided by applicant): Each motoneuron drives the muscle fibers it innervates in a one-to-one fashion, thus forming a motor unit. Because muscle fiber action potentials are relatively easy to measure, motoneurons are the only CNS cells whose firing patterns can be readily quantified in human subjects. Thus, the motoneuron potentially provides a unique window on CNS function in both normal and disease states. The cellular mechanisms that drive motoneuron firing patterns, however, can only be measured via intracellular studies in animal preparations. Thus, the design of our meeting is inherently cross-disciplinary: to bring together specialists investigating motor unit firing patterns in human subjects with specialists focusing on cellular mechanisms underlying motoneuron electrical behavior. To facilitate interactions between labs, each session consists of an introduction for non-specialists, short presentations, and extended time for discussion. Each session will have at least one presentation by a post-doctoral fellow or a graduate student. The meeting will begin with cellular presentations and proceed to human data, with the transition focusing on recent developments in high speed, biologically realistic computer simulations that potentially provide a platform for quantitatively relating these two types of data. The issue at the heart of the meeting is, to what degree the present state-of-the- art results and simulations allow identification of the cellular mechanisms of plastic changes that take place in motor unit firing patterns both in normal function (fatigue, exercise) and in disease states (spinal injury, hemiparetic stroke, and ALS). The meeting will end with an entire session devoted to discussion of this fundamental question. The abstracts submitted by each invited speaker will be posted on a publicized website. We anticipate that this meeting will generate new ideas and approaches for investigation of plasticity in the motor system as well as creation of new therapeutic strategies for spasticity in spinal injury and stroke and motoneuron degeneration in ALS. PUBLIC HEALTH RELEVANCE: This application seeks support for international meeting on mechanisms of plasticity and disease in motoneurons. The 3.5 day conference will bring together specialists investigating motor unit firing patterns in human subjects with specialists focusing on cellular mechanisms underlying motoneuron electrical behavior.

描述（由申请人提供）：每个运动神经元以一对一的方式驱动其支配的肌纤维，从而形成运动单元。由于肌纤维动作电位相对容易测量，运动神经元是唯一的中枢神经系统细胞，其放电模式可以很容易地量化在人类受试者。因此，运动神经元可能提供了一个独特的窗口，在正常和疾病状态下的CNS功能。然而，驱动运动神经元放电模式的细胞机制只能通过动物制备的细胞内研究来测量。因此，我们会议的设计本质上是跨学科的：将研究人类受试者运动单元放电模式的专家与专注于运动神经元电行为背后的细胞机制的专家聚集在一起。为了促进实验室之间的互动，每次会议都包括非专业人士的介绍，简短的演讲和延长的讨论时间。每节课将至少有一个博士后研究员或研究生的演讲。会议将开始与细胞介绍，并进行人体数据，与过渡集中在高速，生物逼真的计算机模拟，可能提供一个平台，定量相关的这两种类型的数据的最新发展。会议的核心问题是，目前最先进的结果和模拟在多大程度上允许识别在正常功能（疲劳，运动）和疾病状态（脊髓损伤，轻偏瘫中风和ALS）中运动单位放电模式中发生的塑性变化的细胞机制。会议结束时将举行一次全体会议，专门讨论这一根本问题。每位受邀发言者提交的摘要将张贴在一个公开网站上。我们预计，这次会议将产生新的想法和方法，在运动系统的可塑性的调查，以及创造新的治疗策略，痉挛的脊髓损伤和中风和运动神经元变性的ALS。 公共卫生相关性：该申请寻求对运动神经元可塑性和疾病机制国际会议的支持。为期3.5天的会议将汇集研究人类受试者运动单位放电模式的专家，以及专注于运动神经元电行为背后的细胞机制的专家。