Adolescent Screener and Opioid Assessment for Patients with Pain (A-SOAPP)

针对疼痛患者的青少年筛查和阿片类药物评估 (A-SOAPP)

• 批准号: 8712755
• 负责人: Kimberlee Jean Trudeau
• 金额: $ 19.48万
• 依托单位: INFLEXXION, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8712755
• 关键词: Accounting; Achievement; Adolescent; Adult; Age; Alcohol or Other Drugs use; Behavior; Behavioral; Boston; Cancer Patient; Caregivers; Categories; Childhood; Clinical; Cognitive; Complex; Cystic Fibrosis; Data; Development; Etiology; Evaluation; Exercise; Goals; Health Personnel; Hemophilia A; Individual; Institution; Interview; Letters; Malignant Neoplasms; Medical; Medical History; Methods; Minority; Modeling; Monitor; Opioid; Opioid Analgesics; Organ Transplantation; Outcome; Pain; Pain management; Parents; Patient Self-Report; Patients; Pediatric Hospitals; Pharmaceutical Preparations; Phase; Population; Preventive screening; Process; Provider; Psychometrics; Recovery; Recurrent pain; Research; Review Literature; Risk; Role; Saint Jude Children' s Research Hospital; Secondary pain; Services; Sickle Cell Anemia; Sorting - Cell Movement; Source; Specialist; Specific qualifier value; Target Populations; Testing; Toxicology; Transplantation; Urine; Youth; addiction; aged; base; chronic pain; high risk; innovation; interest; meetings; member; opioid misuse; patient population; pill; predictive modeling; prescription opioid; public health relevance; screening; tool

DESCRIPTION (provided by applicant): Pain management including the use of opioid analgesics is recommended for adolescents who are suffering from recurrent or chronic pain associated with a specific etiology such as cancer, cystic fibrosis, sickle cell anemia, hemophilia or organ transplants (see citations by etiology in letter of support from CO-I, Dr. Solodiuk). Preventive screening tools provide information that can be used by the provider to inform prescription choices (use of opioid versus another medication) and subsequent monitoring (e.g., urine screens, pill counts), resulting in safe and effective pain management. Pediatric hospitals are currently using screeners developed and tested with other populations because there is no validated tool for this specific patient population. The primary aim of this application is to begi development of a screening tool called the Adolescent Screener and Opioid Assessment for Patients with Pain (A-SOAPP) for use with adolescent-aged patients with secondary, recurrent or chronic pain accompanying complex medical conditions like cancer. The A-SOAPP will fill a void that exists for a screening tool to help healthcare providers identify individuals who may be at increased risk for opioid misuse among those patients being considered for episodic or long-term opioid therapy, including cancer patients and patients with sickle cell disease. Similar to development of the adult version, a rigorous methodical approach will be employed to develop a screener with stable, high predictive validity. An adolescent version of such a screener presents significant psychometric challenges including item content that is age-appropriate, accounting for the role of caregivers in the administration and monitoring of medication use, and operationally defining indicators of aberrant medication-related behaviors and signs indicating possible addiction in this population. Thus, in addition to meeting an important clinical need, an age-appropriate, population-appropriate screener for opioid risk represents a significant innovation in the field. In our view, the achievement of this goal will require the concept of a "screener" to deviate from the self-report behavioral screeners typically used to detect or predict substance use problems. Rather, this screener will endeavor to capitalize on predictive relations of data from a variety of sources (e.g., provider observations, demographic information, medical history, as well as patient self-report), to best model and predict the outcome of interest, namely aberrant medication-related behaviors.

描述（由申请人提供）：疼痛管理（包括使用阿片类镇痛剂）推荐用于患有与特定病因（如癌症、囊性纤维化、镰状细胞性贫血、血友病）相关的复发性或慢性疼痛的青少年 或器官移植（见Solodiuk博士的支持信中按病因列出的引文）。预防性筛查工具提供的信息可供提供者用于告知处方选择（使用阿片类药物与另一种药物）和后续监测（例如，尿液筛查，药丸计数），从而安全有效地管理疼痛。儿科医院目前正在使用与其他人群一起开发和测试的筛查仪，因为没有针对这一特定患者人群的有效工具。本申请的主要目的是开始开发一种称为疼痛患者青少年筛查和阿片类药物评估（A-SOAPP）的筛查工具，用于患有继发性、复发性或慢性疼痛伴发复杂医学疾病（如癌症）的中老年患者。A-SOAPP将填补筛选工具的空白，以帮助医疗保健提供者在考虑进行间歇性或长期阿片类药物治疗的患者中识别可能存在阿片类药物滥用风险增加的个体，包括癌症患者和镰状细胞病患者。与成人版本的开发类似，将采用严格的方法开发具有稳定、高预测有效性的筛选器。青少年版本的这样一个筛选器提出了重大的心理挑战，包括项目内容，是年龄合适的，占照顾者的作用，在管理和监测药物的使用，并在操作上定义指标的异常药物相关的行为和迹象表明可能在这个人群中成瘾。因此，除了满足重要的临床需求外，适合年龄、人群的阿片类药物风险筛查代表了该领域的重大创新。在我们看来，要实现这一目标，就需要“筛选者”的概念偏离通常用于检测或预测的自我报告行为筛选者 物质使用问题。相反，这个筛选器将奋进利用来自各种来源的数据的预测关系（例如，提供者观察、人口统计学信息、病史以及患者自我报告），以最佳地建模和预测感兴趣的结果，即 与药物有关的异常行为