The Role of Neural Systems for Emotion Regulation in Coping with Alcohol Craving

情绪调节神经系统在应对酒精渴望中的作用

• 批准号: 8618358
• 负责人: Nasir Hasnain Naqvi
• 金额: $ 18.62万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-01 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8618358
• 关键词: Abstinence; Address; Affect; Affective; Aftercare; Alcohol dependence; Alcohols; Amygdaloid structure; Anterior; Area; Behavior; Behavioral; Clinical; Clinical Research; Clinical Trials; Cognitive; Cognitive Therapy; Coping Skills; Cues; Data; Development; Doctor of Philosophy; Down-Regulation; Educational process of instructing; Emotions; Ensure; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Generations; Goals; Grant; Individual Differences; Inpatients; Insula of Reil; Intervention; K-Series Research Career Programs; Lead; Literature; Mediating; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modeling; Morbidity - disease rate; Motivation; Patients; Pharmaceutical Preparations; Play; Prefrontal Cortex; Principal Investigator; Process; Psychiatrist; Rehabilitation therapy; Relapse; Research; Research Personnel; Research Project Grants; Role; Scanning; Self Efficacy; Severities; System; Testing; Therapeutic; Therapeutic Effect; Thinking; Time; Training; Training Programs; Translational Research; Ventral Striatum; Visit; Writing; addiction; alcohol craving; alcohol cue; alcohol response; behavior change; career; cingulate cortex; clinically relevant; cognitive neuroscience; cognitive training; coping; craving; disorder later incidence prevention; drinking; drinking behavior; emotion regulation; evidence base; experience; follow-up; improved; innovation; mortality; neural patterning; neuroadaptation; neuroimaging; neuromechanism; novel; patient oriented research; programs; psychosocial; public health relevance; relating to nervous system; research study; response; skills; social; therapy development; translational approach; treatment duration

DESCRIPTION (provided by applicant): In this application for a K23 Career Development Award, the Principal Investigator, Nasir Naqvi, MD, PhD, proposes a comprehensive plan for becoming an independent translational researcher who is capable of integrating cognitive neuroscience and clinical methods in order to elucidate the neural mechanisms by which psychosocial treatments for alcohol dependence change behavior. Psychosocial treatments are commonly utilized, though they remain at best only moderately effective. By identifying the neural mechanisms through which psychosocial treatments change drinking behavior, it may be possible to improve their efficacy. The project focuses specifically on Cognitive Behavioral Coping Skills Therapy (CBCST), an evidence-based psychosocial treatment that promotes abstinence by teaching "coping skills" for managing alcohol-related thoughts and emotions. The proposed research combines (1) a clinical trial of CBCST in alcohol dependent patients who have completed inpatient rehabilitation and have a goal of maintaining abstinence with (2) functional MRI (fMRI) experiments that probe neural activity related to the utilization of a specifc coping skill that is taught in CBCST: reducing cue-induced craving by thinking about the negative consequences of drinking. The fMRI studies will be performed both before and immediately after treatment with CBCST, with the goal of determining (1) the pattern of neural activity that is related to coping skills utilization prior to undergoing CBCST, with particular fous on neural systems known to play a role in emotion regulation~ (2) whether this pattern of neural activity predicts abstinence vs. relapse during CBCST~ and (3) how CBCST changes this pattern of neural activity. While pursuing this line of research under the guidance of mentors who are recognized experts in psychosocial treatment mechanisms (Jon Morgenstern, PhD) and the cognitive neuroscience of emotion regulation (Kevin Ochsner, PhD), Dr. Naqvi will engage in a comprehensive training program in the following areas: (1) fMRI methods~ (2) clinical trials methods~ (3) translational neuroimaging~ (4) the relevant literature on social cognitive neuroscience, emotion regulation and psychosocial treatment mechanisms~ and (5) grant writing and management skills. This training program will build upon Dr. Naqvi's background as an addiction psychiatrist who has significant experience treating alcohol dependence, but who has relatively little experience in clinical research. Furthermore, while Dr. Naqvi is a PhD-trained cognitive neuroscientist who has already made substantial contributions to our understanding of the pathophysiology of addiction, he has no prior training or experience using fMRI methods. Thus, the K23 award will support an innovative and clinically relevant program of patient-oriented research, while helping Dr. Naqvi acquire critical skills that will ensure his development into an independent translational researcher.

描述（由申请人提供）：在K23职业发展奖的申请中，主要研究者Nasir Naqvi，MD，PhD提出了一项全面的计划，旨在成为一名能够整合认知神经科学和临床方法的独立翻译研究人员，以阐明酒精依赖的心理社会治疗改变行为的神经机制。心理社会治疗是常用的，虽然他们仍然充其量只有适度的有效性。通过确定心理社会治疗改变饮酒行为的神经机制，有可能提高其疗效。该项目特别侧重于认知行为应对技能疗法（CBCST），这是一种循证心理治疗，通过教授管理与酒精有关的思想和情绪的“应对技能”来促进戒酒。这项研究结合了（1）在酒精依赖患者中进行的CBCST临床试验，这些患者已完成住院康复并有保持戒酒的目标;（2）功能性MRI（fMRI）实验，该实验探测与CBCST中教授的特定应对技能的利用相关的神经活动：通过思考饮酒的负面后果来减少线索诱导的渴望。将在CBCST治疗前和治疗后立即进行fMRI研究，目的是确定（1）在接受CBCST之前与应对技能利用相关的神经活动模式，特别关注已知在情绪调节中起作用的神经系统~（2）这种神经活动模式是否预测CBCST期间的戒断与复发~和（3）CBCST如何改变这种神经活动模式在心理社会治疗机制方面公认的专家导师的指导下进行这一系列研究的同时，（Jon Morgenstern博士）和情绪调节的认知神经科学（Kevin Ochsner博士），Naqvi博士将在以下领域开展全面的培训计划：（1）fMRI方法~（2）临床试验方法~（3）转化神经影像学~（4）社会认知神经科学的相关文献，情绪调节和心理社会治疗机制~和（5）授予写作和管理技能。Naqvi博士是一名成瘾精神病学家，在治疗酒精依赖方面有丰富的经验，但在临床研究方面的经验相对较少。此外，虽然纳克维博士是一位博士培训的认知神经科学家，他已经为我们理解成瘾的病理生理学做出了重大贡献，但他之前没有接受过功能磁共振成像方法的培训或经验。因此，K23奖将支持创新且临床相关的以患者为导向的研究计划，同时帮助Naqvi博士获得关键技能，以确保他发展成为一名独立的转化研究人员。