Eukaryotic Heme Utilization

真核血红素利用

• 批准号: 8939623
• 负责人: Caroline Philpott
• 金额: $ 7.76万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8939623
• 关键词: Binding; Biochemical; Biological; Cells; Copper; Cytosol; Environment; Enzymes; Eukaryota; Friedreich Ataxia; Genes; Genetic; Heme; Heme Iron; Hemoglobin; Hereditary Disease; Hereditary hemochromatosis; Homeostasis; Human; Intracellular Transport; Iron; Iron Compounds; Iron Overload; Mammals; Metabolism; Mitochondria; Myoglobin; Nutrient; Organic Iron Compounds; Organism; Oxygen; Process; Regulation; Role; Saccharomyces cerevisiae; Saccharomycetales; System; Toxin; Yeasts; Zinc; aqueous; cofactor; deprivation; heme a; human disease; insight; iron metabolism; metal metabolism; microorganism; response; trafficking; uptake

Very little is known about heme transport in eukaryotes and a heme-specific transport uptake systems have not been identified in yeast. Heme is synthesized in mitochondria, yet the cofactor is used in compartments throughout the cell. Heme is highly hydrophobic and is unlikely to be released into the aqueous environment of the cytosol, suggesting that mechanisms exist for the intracellular trafficking of heme. We are currently characterizing the heme efflux activity of the putative mitochondrial heme exporter of humans, FLVCR1b.

关于血红素在真核生物中的转运知之甚少，并且在酵母中还没有鉴定出血红素特异性转运摄取系统。血红素是在线粒体中合成的，而辅因子则在整个细胞的各个区域中使用。血红素是高度疏水性的，并且不太可能被释放到胞质溶胶的水性环境中，这表明存在血红素的细胞内运输的机制。 我们目前正在表征血红素流出活性的推定线粒体血红素出口的人，FLVCR1b。