Translation of a Lung Cancer Palliative Care Intervention for Clinical Practice

描述（由申请人提供）：肺癌是美国第二大常见癌症，占所有新发癌症病例的55%。它是所有新癌症病例的第二大原因，但却是男女死亡的第一大原因。在治疗目的不是一种选择的情况下，并且在呈现的晚期是常见的，姑息治疗成为肺癌患者护理的一个重要方面。跨学科姑息治疗模式可以有效地将肺癌患者及时与适当的支持性护理服务联系起来。家庭照顾者（FCG）也主要参与肺癌患者的护理，承担支持患者度过疾病轨迹的主要责任。本研究的目的是检测姑息治疗干预（PCI）在非小细胞肺癌（NSCLC）及其原发性FCG患者中的传播情况。PCI是在City of Hope进行的一项计划项目（P01）中开发和测试的，在约400名肺癌患者和350名FCG中进行。传播计划将以RE-AIM模式为指导。我们的具体目标包括从P01到三个姑息治疗研究合作组（PCRC）网站的干预适应，并测试干预对患者和FCG结果的影响。我们假设PCI干预将改善患者的生活质量、症状和痛苦，并改善FCG的负担、痛苦和生活质量。PCI干预由几个部分组成，包括对患者和FCG需求的全面QOL评估，与跨学科团队一起制定姑息治疗计划，以及患者和FCG教学课程。该应用程序是与巴勒斯坦权力机构合作开发的，数据管理和分析将在巴勒斯坦权力机构数据和统计中心进行。它涉及NINR在RFA中确定的三个广泛领域，包括：1）生物行为研究; 2）姑息治疗谱沿着过渡的影响; 3）护理问题。

DESCRIPTION (provided by applicant): Lung cancer is the second most common cancer in the United States, accounting for 55% of all new cancer cases. It is the second leading cause of all new cancer cases but the first leading cause of death across genders. In cases where curative intent is not an option, and advanced stages at presentation is common, palliative care becomes an important aspect of care for lung cancer patients. An interdisciplinary palliative care model can effectively link lung cancer patients to the appropriate supportive care services in a timely fashion. Family caregivers (FCG) are also centrally involved in the care of lung cancer patients, assuming primary responsibility for supporting patients across the trajectory of disease. The purpose of this study is to test the dissemination of a Palliative Care Intervention (PCI) for patients with non-small cell lung cancer (NSCLC) and their primary FCG. The PCI was developed and tested in a Program Project (P01) conducted at the City of Hope in approximately 400 lung cancer patients and 350 FCGs. The dissemination plan will be guided by the RE-AIM model. Our specific aims include the adaptation of the intervention from the P01 into three Palliative Care Research Cooperative Group (PCRC) sites, and testing the impact of the intervention on patient and FCG outcomes. We hypothesize that the PCI intervention will improve QOL, symptoms, and distress for patients, and improve burden, distress, and QOL for FCGs. The PCI Intervention consists of several components, and includes a comprehensive QOL assessment of patient and FCG needs, development of palliative care plan with an interdisciplinary team, and patient and FCG teaching sessions. This application has been developed in collaboration with the PCRC, with data management and analysis to be conducted at the PCRC Data and Statistics Center. It addresses the three broad areas identified by the NINR in the RFA including: 1) Bio behavioral research; 2) The impact of transitions along the palliative care spectrum; and 3) Caregiving issues.