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Vaccines, Immunoprophylaxis, and Immunotherapy for Coronaviruses

Vaccines, Immunoprophylaxis, and Immunotherapy for Coronaviruses
冠状病毒的疫苗、免疫预防和免疫治疗
批准号：
8946543
负责人：
Kanta Subbarao
金额：
$26.27万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8946543
关键词：
Animal ModelCessation of lifeCoronavirusCountryDevelopmentDipeptidyl PeptidasesDiseaseDisease OutbreaksEvaluationFerretsGoalsImmune responseImmunotherapeutic agentImmunotherapyInbred BALB C MiceInfectionLondonMesocricetus auratusMiddle EastModelingMouse StrainsMusNamesOryctolagus cuniculusPathogenesisPatientsPrevention strategyRespiratory SystemRespiratory tract structureSyndromeVaccinesVirusVirus Receptorsagedimmunoprophylaxisnovelpreventrespiratorytreatment strategy

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英文摘要
MERS-CoV strains, including EMC and London strains, reportedly do not replicate in the respiratory tract of various strains of mice, including BALB/c, C57BL/6, and STAT 1-/-, or in aged (12- to 14-months old) BALB/c mice, or in 5-weeks-old golden Syrian hamsters or in ferrets. The receptor for the virus has been identified as a dipeptidyl peptidase 4. We are evaluating the ability of MERS-CoV to infect and replicate in rabbits, in order to develop a model that can be used to study the pathogenesis and immune response to the novel coronavirus. It is not known whether the novel coronavirus can replicate and cause disease in this species.
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