Columbia University Graduate Training Program in Microbiology and Immunology

哥伦比亚大学微生物学和免疫学研究生培训项目

基本信息

  • 批准号:
    8742419
  • 负责人:
  • 金额:
    $ 9.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-06-01 至 2019-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): In this resubmission, we request support for two graduate trainees selected each year, who have attained dissertator status in our predoctoral Columbia University Graduate Training Program in Microbiology and Immunology. Each trainee would be funded for two years. This PhD granting Program, led by our Director Dr. David Fidock and Co-Director Dr. Boris Reizis, provides predoctoral trainees with a unique opportunity to obtain individualized training across a broad spectrum of microbiology and immunology research. This research converges on themes of immune cell and tissue development and homeostasis, pathogen biology, mechanisms of DNA replication and repair, and microbial and immune cell proliferation. These cross-disciplinary interests are being pursued in a highly collaborative and interactive framework that links our 19 training faculty, who are all appointed to the Department of Microbiology & Immunology, led by our Chairman Dr. Sankar Ghosh. Our graduate program, built on many decades of successful graduate training, has proven that we can recruit and retain an outstanding cohort of training grant eligible (TGE) applicants. Trainees take courses in microbiology and immunology, biochemistry, molecular cell biology, genetics, quantitative biology, and responsible conduct in research, and are enrolled in workshops on scientific writing and grantsmanship. Students must also pass a qualifying examination that tests their ability to formulate and defend a hypothesis-driven project unrelated to their thesis research. Our programmatic framework includes a Steering Committee that regularly evaluates student and trainer performance, the curriculum, and new applicants; a process to identify the best trainees and mentor them successfully throughout their graduate studies; a mentoring plan for junior trainers, and an External Review Board with Program Directors who provide regular feedback to help optimize program effectiveness. Our Graduate Program has shown excellent recruitment and retention rates, along with an outstanding record of career outcomes for former predoctoral trainees, including underrepresented minorities or disadvantaged students. 95% of our former trainees in the past decade have continued in science or medicine and 15% have already achieved tenure-track or non tenure-track faculty positions. Our increased emphasis on recruitment of underrepresented minorities includes a new agreement with the University of Puerto Rico, which has a large student body of TGE applicants, and extensive outreach initiatives. We also benefit from very strong institutional support provided by the Dean of our medical school and our Office of Graduate Affairs, including financial support that allows our training grant to support selected trainees once they have successfully completed their coursework and qualifying examination and are engaged in full-time research. We are confident that our dynamic, rigorous and scientifically innovative training program will mold future academic leaders in microbiology and immunology research who will have acquired the skills to be able to tackle critical topics in infectious diseases and immune regulation.
描述(由申请人提供):在本次重新提交的材料中,我们请求为每年选择的两名研究生学员提供支持,他们已在我们的哥伦比亚大学微生物学和免疫学博士前研究生培训项目中获得论文作者身份。每个受训人员将获得两年的资助。这个博士授予计划,由我们的主任大卫Fidock博士和联合主任鲍里斯Reizis博士领导,为博士前学员提供了一个独特的机会,以获得广泛的微生物学和免疫学研究的个性化培训。该研究集中在免疫细胞和组织发育和稳态,病原体生物学,DNA复制和修复机制以及微生物和免疫细胞增殖的主题上。这些跨学科的兴趣正在一个高度协作和互动的框架中进行,该框架将我们的19名培训教师联系起来,他们都被任命为微生物学和免疫学系,由我们的主席Sankar Ghosh博士领导。我们的研究生课程建立在数十年成功的研究生培训基础上,已经证明我们可以招募并留住一批优秀的培训补助金合格(TGE)申请人。受训人员学习微生物学和免疫学、生物化学、分子细胞生物学、遗传学、定量生物学和负责任的研究行为等课程,并参加科学写作和写作讲习班。学生还必须通过资格考试,测试他们制定和捍卫与论文研究无关的假设驱动项目的能力。我们的计划框架包括一个指导委员会,定期评估学生和培训师的表现,课程和新申请人;一个过程,以确定最好的学员,并在他们的研究生学习成功地指导他们;初级培训师的指导计划,以及外部审查委员会与计划主任谁提供定期反馈,以帮助优化计划的有效性。我们的研究生课程显示出出色的招聘和保留率,沿着前博士生的职业成果的杰出记录,包括代表性不足的少数民族或弱势学生。在过去的十年中,95%的前学员继续从事科学或医学工作,15%的人已经获得了终身教职或非终身教职。我们更加重视招聘代表性不足的少数民族,包括与波多黎各大学达成新的协议,该大学有大量的TGE申请学生,以及广泛的外联举措。我们还受益于我们医学院院长和我们的研究生事务办公室提供的非常强大的机构支持,包括财政支持,使我们的培训补助金能够在选定的学员成功完成课程和资格考试并从事全职研究后提供支持。我们有信心,我们的动态,严谨和科学创新的培训计划将塑造未来的微生物学和免疫学研究的学术领导者,他们将获得能够解决传染病和免疫调节关键课题的技能。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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David A Fidock其他文献

Causal chemoprophylactic activity of cabamiquine against emPlasmodium falciparum/em in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands
卡巴醌在受控人类疟疾感染中对恶性疟原虫的因果化学预防活性:荷兰的一项随机、双盲、安慰剂对照研究
  • DOI:
    10.1016/s1473-3099(23)00212-8
  • 发表时间:
    2023-10-01
  • 期刊:
  • 影响因子:
    31.000
  • 作者:
    Johan L van der Plas;Vincent P Kuiper;Wilhelmina M Bagchus;Matthias Bödding;Özkan Yalkinoglu;Aliona Tappert;Andrea Seitzinger;Thomas Spangenberg;Deon Bezuidenhout;Justin Wilkins;Claude Oeuvray;Satish K Dhingra;Vandana Thathy;David A Fidock;Lisanne C A Smidt;Geert V T Roozen;Jan Pieter R Koopman;Olivia A C Lamers;Jeroen Sijtsma;Roos van Schuijlenburg;Akash Khandelwal
  • 通讯作者:
    Akash Khandelwal
Safety, tolerability, pharmacokinetics, and antimalarial activity of MMV533: a phase 1a first-in-human, randomised, ascending dose and food effect study, and a phase 1b emPlasmodium falciparum/em volunteer infection study
MMV533 的安全性、耐受性、药代动力学和抗疟活性:一项 1a 期首次人体、随机、递增剂量和食物效应研究,以及一项 1b 期恶性疟原虫/志愿者感染研究
  • DOI:
    10.1016/s1473-3099(24)00664-9
  • 发表时间:
    2025-05-01
  • 期刊:
  • 影响因子:
    31.000
  • 作者:
    Benoit Bestgen;Sam Jones;Vandana Thathy;Andrea Kuemmerle;Catalina Barcelo;Amina Haouala;Denis Gossen;Michael W Marx;Ilaria Di Resta;Maja Szramowska;Rebecca A Webster;Stacey Llewellyn;Dominic A Ritacco;Tomas Yeo;Didier Leroy;Bridget E Barber;David A Fidock;Paul Griffin;Jason Lickliter;Stephan Chalon
  • 通讯作者:
    Stephan Chalon
emPlasmodium falciparum/em resistance to artemisinin-based combination therapies
  • DOI:
    10.1016/j.mib.2022.102193
  • 发表时间:
    2022-10-01
  • 期刊:
  • 影响因子:
    7.500
  • 作者:
    Kurt E Ward;David A Fidock;Jessica L Bridgford
  • 通讯作者:
    Jessica L Bridgford
Regional action needed to halt antimalarial drug resistance in Africa
需要采取区域行动来阻止非洲的抗疟药物耐药性。
  • DOI:
    10.1016/s0140-6736(24)02706-5
  • 发表时间:
    2025-01-04
  • 期刊:
  • 影响因子:
    88.500
  • 作者:
    Rosario Martinez-Vega;Deus S Ishengoma;Roly Gosling;Philip J Rosenthal;Arjen Dondorp;Karen I Barnes;Christian Nsanzabana;Abdoulaye A Djimde;Lynette I Ochola-Oyier;James Tibenderana;John Chimumbwa;Lemu Golassa;Ntuli A Kapologwe;Wilfred F Mbacham;Moses R Kamya;David A Fidock;Ryuichi Komatsu;Lorenz von Seidlein;Mehul Dhorda
  • 通讯作者:
    Mehul Dhorda

David A Fidock的其他文献

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{{ truncateString('David A Fidock', 18)}}的其他基金

Deciphering the role of Plasmodium falciparum plasmepsin 2/3 amplifications in mutant pfcrt-driven piperaquine resistance
破译恶性疟原虫血浆蛋白酶 2/3 扩增在突变体 pfcrt 驱动的哌喹耐药中的作用
  • 批准号:
    10374934
  • 财政年份:
    2021
  • 资助金额:
    $ 9.18万
  • 项目类别:
Leveraging PfCRT Structure to Discern Function and Predict Emergence of Drug-Resistant Malaria
利用 PfCRT 结构识别功能并预测耐药性疟疾的出现
  • 批准号:
    10443625
  • 财政年份:
    2019
  • 资助金额:
    $ 9.18万
  • 项目类别:
Leveraging PfCRT Structure to Discern Function and Predict Emergence of Drug-Resistant Malaria
利用 PfCRT 结构识别功能并预测耐药性疟疾的出现
  • 批准号:
    10199925
  • 财政年份:
    2019
  • 资助金额:
    $ 9.18万
  • 项目类别:
Leveraging PfCRT Structure to Discern Function and Predict Emergence of Drug-Resistant Malaria
利用 PfCRT 结构识别功能并预测耐药性疟疾的出现
  • 批准号:
    10653063
  • 财政年份:
    2019
  • 资助金额:
    $ 9.18万
  • 项目类别:
Elucidating the molecular basis of piperaquine resistance in Plasmodium falciparum
阐明恶性疟原虫哌喹耐药的分子基础
  • 批准号:
    10595160
  • 财政年份:
    2016
  • 资助金额:
    $ 9.18万
  • 项目类别:
Elucidating the molecular basis of piperaquine resistance and the role of altered hemoglobin metabolism in Plasmodium falciparum
阐明恶性疟原虫哌喹耐药性的分子基础以及血红蛋白代谢改变的作用
  • 批准号:
    9212775
  • 财政年份:
    2016
  • 资助金额:
    $ 9.18万
  • 项目类别:
Elucidating the molecular basis of piperaquine resistance and the role of altered hemoglobin metabolism in Plasmodium falciparum
阐明恶性疟原虫哌喹耐药性的分子基础以及血红蛋白代谢改变的作用
  • 批准号:
    9127601
  • 财政年份:
    2016
  • 资助金额:
    $ 9.18万
  • 项目类别:
Defining P. falciparum resistance to artemisinin-based combination therapies
恶性疟原虫对青蒿素联合疗法的耐药性的定义
  • 批准号:
    9319626
  • 财政年份:
    2014
  • 资助金额:
    $ 9.18万
  • 项目类别:
Defining P. falciparum resistance to artemisinin-based combination therapies
恶性疟原虫对青蒿素联合疗法的耐药性的定义
  • 批准号:
    8788180
  • 财政年份:
    2014
  • 资助金额:
    $ 9.18万
  • 项目类别:
Defining P. falciparum resistance to artemisinin-based combination therapies
恶性疟原虫对青蒿素联合疗法的耐药性的定义
  • 批准号:
    10372215
  • 财政年份:
    2014
  • 资助金额:
    $ 9.18万
  • 项目类别:

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  • 批准号:
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