Pancreatic elastases
胰腺弹性蛋白酶
基本信息
- 批准号:8437036
- 负责人:
- 金额:$ 35.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-01-01 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:Acinar CellAddressAdenovirusesAdvanced DevelopmentAffectApoptoticApplications GrantsBackCattleCell DeathCollaborationsCommunitiesComplexConfusionDataDigestionDiseaseElastasesEnzyme PrecursorsEnzymesExhibitsGenesGenomicsGermanyHumanInflammatoryIsoenzymesMeasuresMediatingMessenger RNAMethodologyMethodsMolecular ChaperonesMusMutationOrthologous GenePancreasPancreatic ElastasePancreatitisPathway interactionsPatientsPeptide HydrolasesPeptide Initiation FactorsPeptidesPhage DisplayPhosphorylationPhysiologicalPhysiologyProtein IsoformsPublishingRNA SplicingRattusReportingResearch DesignRiskRisk FactorsRoleRuminantsSubstrate SpecificitySusceptibility GeneTechnologyTimeTransfectionTrypsinogenUp-RegulationVariantcalreticulinchronic pancreatitischymotrypsinogen Cdesignendoplasmic reticulum stressinhibitor/antagonistinsightmeetingsmutantnovelnovel diagnosticsnovel therapeutic interventionpublic health relevanceresearch studyspecies differencetranscription factor CHOP
项目摘要
DESCRIPTION (provided by applicant): The objectives of the present grant proposal are to characterize the physiological functions of pancreatic elastases and to investigate the mechanism by which elastase mutants act as risk factors for chronic pancreatitis in humans. This grant application is intended to meet a growing need in the pancreas community for the understanding of elastase function both in pancreatic physiology and disease. In humans, there are five pancreatic elastase genes (ELA1, ELA2A, ELA2B, ELA3A, and ELA3B) which give rise to three functional elastases (ELA2A, ELA3A and ELA3B). In the mouse ELA1, ELA2A and ELA3B seem to be expressed. The specific aims studied are designed to address (i) the substrate specificity of human and mouse elastases; (ii) complex formation between proelastases and other pancreatic proteases; and (iii) the functional consequences of proelastase mutations identified in subjects with chronic pancreatitis.
描述(由申请人提供):本资助提案的目的是描述胰腺弹性蛋白酶的生理功能,并研究弹性蛋白酶突变体作为人类慢性胰腺炎危险因素的机制。这项拨款申请旨在满足胰腺社区日益增长的需求,以了解弹性蛋白酶在胰腺生理学和疾病中的功能。在人类中,存在五种胰腺弹性蛋白酶基因(ELA 1、ELA 2A、ELA 2B、ELA 3A和ELA 3B),其产生三种功能性弹性蛋白酶(ELA 2A、ELA 3A和ELA 3B)。在小鼠中,似乎表达ELA 1、ELA 2A和ELA 3B。研究的具体目的旨在解决(i)人和小鼠弹性蛋白酶的底物特异性;(ii)弹性蛋白酶原和其他胰腺蛋白酶之间的复合物形成;以及(iii)在慢性胰腺炎受试者中鉴定的弹性蛋白酶原突变的功能后果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Miklos Sahin-Toth其他文献
Miklos Sahin-Toth的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Miklos Sahin-Toth', 18)}}的其他基金
Digestive enzyme misfolding promotes alcoholic pancreatitis
消化酶错误折叠促进酒精性胰腺炎
- 批准号:
9927478 - 财政年份:2018
- 资助金额:
$ 35.6万 - 项目类别:
CHYMOTRYPSIN C CO-ACTIVATION OF HUMAN PANCREATIC PROCARBOXYPEPTIDASES A1 AND A2
胰凝乳蛋白酶 C 协同激活人胰腺羧肽酶 A1 和 A2
- 批准号:
8365590 - 财政年份:2011
- 资助金额:
$ 35.6万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 35.6万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 35.6万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 35.6万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 35.6万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 35.6万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 35.6万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 35.6万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 35.6万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 35.6万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 35.6万 - 项目类别:
Research Grant