Vitamin D Deficiency, Inflammation and Age-related disease in HIV-Infected Men

HIV 感染男性的维生素 D 缺乏、炎症和年龄相关疾病

• 批准号: 8645957
• 负责人: ALISON G ABRAHAM
• 金额: $ 17.95万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8645957
• 关键词: Acquired Immunodeficiency Syndrome; Affect; Age; Aging; Asses; Biological Markers; Bone Diseases; CD4 Positive T Lymphocytes; Cardiovascular Diseases; Cell Count; Chronic; Chronic Disease; Chronic Kidney Failure; Cognitive; Cohort Studies; Comorbidity; Complex; Data; Disease; Disease Outcome; Elderly; Epidemiologic Studies; Foundations; HIV; Health; High Prevalence; Highly Active Antiretroviral Therapy; Homeostasis; Immune; Individual; Inflammation; Inflammatory; Intervention; Kidney Diseases; Malignant Neoplasms; Measures; Metabolic Diseases; Metabolism; Morbidity - disease rate; Motivation; Outcome; Outcome Study; Participant; Pathway interactions; Persons; Population; Prevalence; Risk; Role; Serum; Site; Supplementation; System; Systems Biology; Time; United States; Universities; Vitamin D; Vitamin D Deficiency; Washington; age related; aging population; base; disorder risk; effective therapy; experience; frailty; high risk; improved; inflammatory marker; insight; interest; men; mortality; novel; public health relevance; reconstitution; success; treatment strategy

DESCRIPTION: There has been great interest in whether vitamin D supplementation might hold potential for influencing health in aging HIV-infected populations. An estimated 60% of HIV-infected persons have subclinical vitamin D deficiency. Given the established immunomodulatory role of vitamin D as well as its myriad other functions, there is a firm foundation for hypothesizing vitamin D deficiency might have disease risk consequences for older HIV-infected persons. The underlying motivation for this proposal is to use a more comprehensive approach to understanding the complex relationships between vitamin D metabolite levels and inflammation and how they relate to aging outcomes among HIV-infected persons. The proposed study will measure two vitamin D metabolites (25[OH]D and the active form, 1,25[OH]2D), before and after the critical time point of HAART initiation. With these measures, we will capitalize on an existing platform of inflammatory biomarker data in 500 HIV- infected men to study the complex connections between inflammation, vitamin D metabolism and age-related disease. The study includes participants from four study sites across the United States and collaborators from University of Washington and Johns Hopkins University. The specific aims of this study are: 1) Characterize serum 25[OH] and 1,25[OH]2D levels across strata of age and HIV-status and evaluate the association of each metabolite with available inflammatory markers before and after HAART initiation 2) Determine the association between serum 25[OH] and 1,25[OH]2D levels pre- and post- HAART and both immune reconstitution and chronic disease/geriatric outcomes by age and HIV-status. Understanding how vitamin D metabolism may vary in HIV-infected individuals and impact risk of disease and poor functioning in an aging population is an important issue that will be supported by the proposed epidemiologic research. The biomarkers being evaluated are modifable in terms of their levels in the body and thus have the potential to form the basis of an intervention for lowering risk of disease.

产品说明：人们对补充维生素D是否可能影响老年艾滋病毒感染人群的健康产生了极大的兴趣。估计60%的艾滋病毒感染者患有亚临床维生素D缺乏症。鉴于维生素D的免疫调节作用及其无数其他功能，假设维生素D缺乏可能对老年艾滋病毒感染者产生疾病风险后果有坚实的基础。该提案的根本动机是使用更全面的方法来了解维生素D代谢物水平和炎症之间的复杂关系，以及它们如何与艾滋病毒感染者的衰老结果相关。 拟议的研究将在HAART开始的关键时间点之前和之后测量两种维生素D代谢物（25[OH]D和活性形式1，25 [OH]2D）。通过这些措施，我们将利用现有的500名HIV感染男性炎症生物标志物数据平台，研究炎症、维生素D代谢和年龄相关疾病之间的复杂联系。这项研究包括来自美国四个研究地点的参与者以及来自华盛顿大学和约翰霍普金斯大学的合作者。这项研究的具体目标是：1）表征不同年龄和HIV状态的血清25[OH]和1，25 [OH]2D水平，并评估HAART开始之前和之后每种代谢物与可用的炎症标志物的关联。HAART前后的25[OH]2D水平以及免疫重建和慢性疾病/老年结局（按年龄和HIV状态）。 了解维生素D代谢如何在HIV感染者中变化，以及如何影响疾病风险和老龄化人群中的功能障碍，是一个重要的问题，将得到拟议的流行病学研究的支持。正在评估的生物标志物在体内的水平是可以改变的，因此有可能成为降低疾病风险的干预措施的基础。