Eye Determinants of Cognition (EyeDOC) Study

眼部认知决定因素 (EyeDOC) 研究

基本信息

  • 批准号:
    9175612
  • 负责人:
  • 金额:
    $ 72.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-15 至 2020-05-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Eye Determinants of Cognition (EyeDOC) Study Rationale: Dementia and mild cognitive impairment (MCI) pose enormous health and societal costs in our aging US population. While cerebral neural loss is known to contribute to Alzheimer's dementia, vascular diseases may contribute substantially to the total burden of dementia and its precursor, MCI. Small-vessel cerebrovascular changes, which are most strongly associated with cognitive impairments, are difficult to detect with brain imaging. However, recent technological advances in ocular coherence tomography (OCT) provide refined measures of the microvascular pathology and neurodegeneration of retinal ganglion cells which may provide sensitive biomarkers reflecting underlying cerebral processes. Design: The EyeDOC study will be nested in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS), recruiting 1,000 participants (50% African-American) from two ARIC-NCS field sites (Jackson MS and Washington County, MD) to take part in a comprehensive vision assessment with photographic and OCT imaging of the retina. The EyeDOC visit will occur within 3 months of the ARIC NCS visit 6, and prior to ARIC NCS visit 7, capitalizing on the study's extensive neurocognitive testing and longitudinal design. Exposures: EyeDOC will contribute novel ocular measures to the rich ARIC NCS data including: A. Degree of neurodegeneration marked by loss/thinning of the macular ganglion cell complex [GCC] and the retinal nerve fiber layer [NFL] just outside the optic nerve head B. Degree of microvascular pathology marked by a lower macular vessel density, enlarged area of macular non-perfusion and lower average macular blood flow [flow index]. Outcomes: The late life cognitive outcomes available from ARIC-NCS include: A. Decline in global cognitive ability, executive function/processing speed, memory, and language – assessed using neurocognitive testing in V5, V6 and V7. B. Incidence of MCI, which was diagnosed in approximately 20% of the cohort in V5 and is expected to affect a larger percentage at V6 and V7 due to advancing age of the cohort. Aims: We will assess the relationships of 1) retinal neurodegenerative measures with incident MCI and a pattern of cognitive decline consistent with Alzheimer's disease and 2) retinal microvascular abnormalities with incident MCI and a pattern of cognitive decline consistent with cerebral small vessel disease. Thus, the primary focus will be the impact of NFL thinning on a decline in memory and the impact of reduced capillary blood flow and non-perfusion area on a decline in executive function/processing speed. Summary: The EyeDOC study will demonstrate the potential of retinal biomarkers to inform the etiology of observed cognitive changes and provide a proof of concept for OCT to be used as an effective screening tool for determining the underlying cause(s) of cognitive aging.
项目摘要 眼认知决定因素(EyeDOC)研究 理由:痴呆症和轻度认知障碍(MCI)在我们的国家造成巨大的健康和社会成本。 美国人口老龄化。虽然已知脑神经缺失会导致阿尔茨海默氏痴呆症,但血管性 这些疾病可能在很大程度上导致痴呆及其前体MCI的总负担。小血管 脑血管变化与认知障碍的关系最为密切, 大脑成像。然而,眼相干断层扫描(OCT)的最新技术进步提供了 视网膜神经节细胞的微血管病理学和神经变性的精确测量, 提供反映潜在大脑过程的敏感生物标志物。 设计:EyeDOC研究将嵌入社区神经认知研究中的动脉粥样硬化风险 (ARIC-NCS),从两个ARIC-NCS现场招募1,000名参与者(50%是非裔美国人)(杰克逊 MS和华盛顿县,MD)参加一项全面的视力评估, 视网膜的OCT成像。EyeDOC访视将在ARIC NCS访视6后3个月内进行,并在 ARIC NCS访视7,利用研究的广泛神经认知测试和纵向设计。 暴露:EyeDOC将为丰富的ARIC NCS数据提供新的眼部测量方法,包括: A.以黄斑神经节细胞复合体[GCC]丢失/变薄为标志的神经变性程度 而视网膜神经纤维层就在视神经头外面 B。微血管病变的程度以较低的黄斑血管密度, 黄斑无灌注和较低的平均黄斑血流[血流指数]。 结局:ARIC-NCS提供的晚期认知结局包括: A.整体认知能力、执行功能/处理速度、记忆力和语言能力下降- 在V5、V6和V7中使用神经认知测试进行评估。 B。MCI的发生率,在V5时约20%的队列中诊断出MCI,预计 由于队列的年龄增长,V6和V7的影响百分比更大。 目的:我们将评估1)视网膜神经退行性指标与MCI事件的关系, 与阿尔茨海默病一致的认知下降模式和2)视网膜微血管异常 伴有轻度认知障碍和认知能力下降,与脑小血管疾病一致。因此 主要重点将是NFL变薄对记忆力下降的影响以及毛细血管减少的影响。 血流和非灌注区的执行功能/处理速度下降。 总结:EyeDOC研究将证明视网膜生物标志物的潜力,以告知病因, 观察到的认知变化,并为OCT用作有效筛查提供了概念证明 用于确定认知老化的根本原因的工具。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ALISON G ABRAHAM其他文献

ALISON G ABRAHAM的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ALISON G ABRAHAM', 18)}}的其他基金

Eye Determinants of Cognition (EyeDOC) Study
眼部认知决定因素 (EyeDOC) 研究
  • 批准号:
    9345988
  • 财政年份:
    2016
  • 资助金额:
    $ 72.87万
  • 项目类别:
Novel approaches to characterize depressive symptoms and cognitive outcomes
描述抑郁症状和认知结果的新方法
  • 批准号:
    8848143
  • 财政年份:
    2014
  • 资助金额:
    $ 72.87万
  • 项目类别:
Novel approaches to characterize depressive symptoms and cognitive outcomes
描述抑郁症状和认知结果的新方法
  • 批准号:
    9260137
  • 财政年份:
    2014
  • 资助金额:
    $ 72.87万
  • 项目类别:
Novel approaches to characterize depressive symptoms and cognitive outcomes
描述抑郁症状和认知结果的新方法
  • 批准号:
    8721662
  • 财政年份:
    2014
  • 资助金额:
    $ 72.87万
  • 项目类别:
Vitamin D Deficiency, Inflammation and Age-related disease in HIV-Infected Men
HIV 感染男性的维生素 D 缺乏、炎症和年龄相关疾病
  • 批准号:
    8645957
  • 财政年份:
    2013
  • 资助金额:
    $ 72.87万
  • 项目类别:
Biostatistics Module
生物统计模块
  • 批准号:
    10700922
  • 财政年份:
    1997
  • 资助金额:
    $ 72.87万
  • 项目类别:
Biostatistics Module
生物统计模块
  • 批准号:
    10020644
  • 财政年份:
    1997
  • 资助金额:
    $ 72.87万
  • 项目类别:
Biostatistics Module
生物统计模块
  • 批准号:
    10256786
  • 财政年份:
    1997
  • 资助金额:
    $ 72.87万
  • 项目类别:
Biostatistics Module
生物统计模块
  • 批准号:
    9795548
  • 财政年份:
  • 资助金额:
    $ 72.87万
  • 项目类别:

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 72.87万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 72.87万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 72.87万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 72.87万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 72.87万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 72.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 72.87万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 72.87万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 72.87万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 72.87万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了