Investigating how bottom-up and top-down processes relate to alcohol use disorder

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DESCRIPTION (provided by applicant): The primary objective of this project is to elucidate how bottom-up (e.g., urges for alcohol's reinforcing effects) and top-down (e.g., the ability to control urges for rewarding/thrilling sensations) processes are related to problematic alcohol use at the phenotypic, latent genetic and environmental, and genotypic levels. Specific Aims There are two primary research aims of this project. The first aim is to investigate whether bottom-up and top- down processes account for common mechanisms of risk for problematic alcohol use. Two analytic approaches will be used to address this aim: 1) analyses will investigate the degree to which these processes account for common phenotypic, latent genetic, or latent environmental variance in alcohol outcomes, and 2) a [pilot investigation will examine] whether there are genetic markers associated with bottom-up and/or top-down processes that are also associated with problematic alcohol use. The second aim is to investigate whether there are interaction effects between these processes that explain problematic alcohol use at the phenotypic and latent genetic levels. Analytic approaches addressing this aim will investigate whether top-down (i.e., control-based) processes moderate the relationship between bottom-up (i.e., urge-based) processes and alcohol outcomes [and whether genetic factors account for that moderation effect]. Analyses will be conducted in two datasets, a multiwave dataset of adults (followed from ages 18 to 35) that includes genotypic data and a national community-based twin registry of adults (mean age=37). Significance The results from this project offer to provide important foundational work for translating basic personality and genetic research to applied contexts. For example, some interventions for alcohol use disorder attempt to specifically target bottom-up or top-down processes, and findings from the current project may facilitate the development of effective interventions.