Emotional Processing and Brain Activity in Youth at High Risk for Alcoholism

酗酒高危青少年的情绪处理和大脑活动

• 批准号: 8467579
• 负责人: Anita Cservenka
• 金额: $ 2.2万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8467579
• 关键词: Adolescent; Adult; Affective; Alcohol abuse; Alcoholism; Amygdaloid structure; Area; Behavior; Behavioral; Brain; Brain region; Child; Corpus striatum structure; Development; Emotional; Evaluation; Exhibits; Face; Family history of; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Heavy Drinking; Image; Incidence; Individual; Magnetic Resonance Imaging; Measures; Parietal; Performance; Phenotype; Prevention strategy; Process; Recording of previous events; Regulation; Research; Rest; Risk; Risk Factors; Stimulus; Structure; Symptoms; System; Time; Work; Youth; alcohol use disorder; behavior measurement; brain behavior; brain volume; cognitive control; cognitive function; drinking; emotional stimulus; executive function; high risk; insight; neural circuit; parental alcoholism; peer; prevent; problem drinker; relating to nervous system; response

DESCRIPTION (provided by applicant): Individuals with alcohol use disorders (AUDs) have deficits in emotional processing as well as atypical function and structure in brain regions important for affective regulation. These symptoms are often associated with problems in executive functioning. Interestingly, even prior to heavy alcohol use, youth with a family history of alcoholism (FHP) are at greater risk for emotional problems and exhibit deficits in cognitive control compared to youth without a family history of alcoholism (FHN). Given that FHP youth are at much greater risk for developing an AUD than FHN youth, it is essential to clarify whether brain and behavior phenotypes related to affective processing and executive functioning may be premorbid risk factors for the development of AUDs in FHP youth. Thus, the goal of this study is to investigate brain function and behavior related to emotional processing in FHP youth, as well as examine their associations with executive functioning, prior to heavy alcohol use. Specifically, this research plan will investigate emotional processing and its association with cognitive functioning using behavioral measures, functional magnetic resonance imaging, and resting state functional connectivity magnetic resonance imaging in FHP and FHN youth. By examining brain activity and behavior in FHP and FHN youth prior to heavy alcohol use, this study will provide insight into the neural and behavioral phenotypes associated with familial alcoholism, which may relate to the increased risk for developing AUDs. Understanding whether atypical emotional processing and associated deficits in cognitive control are present in FHP youth prior to heavy alcohol use will allow future research to establish prevention strategies aimed at reducing the development of AUDs.

描述(由申请人提供)：酒精使用障碍(AUD)患者在情绪处理方面存在缺陷，大脑中对情绪调节至关重要的区域的功能和结构也不典型。这些症状通常与执行功能的问题有关。有趣的是，即使在大量饮酒之前，有酗酒家族史(FHP)的年轻人比没有酗酒家族史(FHN)的年轻人更容易出现情绪问题，并表现出认知控制方面的缺陷。鉴于FHP青年患AUD的风险比FHN青年高得多，有必要澄清与情感处理和执行功能相关的大脑和行为表型是否可能是FHP青年AUDS发病前的危险因素。因此，这项研究的目标是调查FHP青少年的大脑功能和与情绪处理相关的行为，以及在大量饮酒之前，检查它们与执行功能的关系。具体地说，这项研究计划将使用行为测量、功能磁共振成像和静息状态功能连接磁共振成像来调查FHP和FHN青少年的情绪处理及其与认知功能的关系。通过检测FHP和FHN青少年在酗酒前的大脑活动和行为，这项研究将提供与家族性酒精中毒相关的神经和行为表型的洞察，这可能与患AUDS风险增加有关。了解FHP青少年在大量饮酒之前是否存在非典型情绪处理和相关的认知控制缺陷，将使未来的研究能够建立旨在减少AUDS发展的预防策略。