Understanding Susceptibility to Olfactory Decline in Aging

了解衰老过程中嗅觉下降的易感性

• 批准号: 8659328
• 负责人: JAYANT M PINTO
• 金额: $ 14.86万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8659328
• 关键词: Abbreviations; Affect; Age; Aging; American; Award; Behavior; Chicago; Chromosome Mapping; Clinical; Cognitive; Communities; Comorbidity; Complex; Copy Number Polymorphism; DNA; DNA Resequencing; Data; Data Set; Demography; Development; Diagnosis; Diagnostic; Discrimination; Disease; Economics; Elderly; Environmental Exposure; Epidemiologic Studies; Esthesia; Functional disorder; Future; Genes; Genetic; Genetic Heterogeneity; Genetic Polymorphism; Genetic Variation; Genotype; Gerontology; Goals; Head and Neck Surgery; Health; Home environment; Human; Impaired cognition; Impairment; Individual; Lead; Life; Life Style; Linkage Disequilibrium; Lung diseases; Master' s Degree; Measures; Medical; Medical History; Memory; Mental Depression; Mentorship; Modality; Modeling; Molecular Profiling; Nose; Odds Ratio; Otolaryngology; Participant; Pathogenesis; Performance; Personal Satisfaction; Phenotype; Physical Function; Physiology; Population; Population Study; Predisposing Factor; Predisposition; Probability Samples; Process; Public Health; Quality Control; Quality of life; Quantitative Trait Loci; Religion and Spirituality; Research; Resources; Retirement; Risk; Risk Factors; Safety; Sampling; Scientist; Sensory; Sensory Disorders; Sexuality; Signal Transduction; Single Nucleotide Polymorphism; Smell Perception; Social Conditions; Social Functioning; Socioeconomic Status; Specimen; Stress; Structure; Testing; Therapeutic; Time; Training; Training Programs; Universities; Variant; Work; age related; career; cohort; demographics; density; experience; gene discovery; genetic association; genetic epidemiology; genetic risk factor; genome wide association study; hutterite; improved; insight; interdisciplinary collaboration; meetings; multidisciplinary; non-genetic; novel strategies; nutrition; pleasure; prognostic; programs; psychologic; psychosocial; skills; social; trait

DESCRIPTION (provided by applicant): Age-related olfactory loss is an important public health problem affecting approximately 14 million older Americans. The profound burden this sensory impairment causes in the daily lives of older people is associated with a substantially decreased quality of life, affecting critical functions such as safety, nutrition, sensation of pleasure, and general well-being. Because olfaction declines over time, the clinical impact will increase as our population ages. Previous studies of this decline in olfactory physiology in humans have been limited, requiring novel approaches to understanding factors that affect this process. In this application, I propose to characterize factors that underlie susceptibility to ag-related olfactory decline. Using data from the Memory and Aging Project (MAP) and the National Social Life, Health, and Aging Project (NSHAP), I plan to identify biodemographic factors that are associated with age-related olfactory decline. These robust resources, in which health and olfactory data have been collected previously along with relevant biomeasures, will allow an analysis of medical and psychosocial parameters that are associated with olfactory loss in older persons. In parallel, I will examine genetic risk factors for this phenotype by performing genome-wide association studies (GWAS) using existing genotype data in MAP and in the Hutterites, a population which has a number of distinct advantages for genetic mapping, including uniform environmental exposures and rich clinical information on relevant co-morbidities. This line of study will involve analysis of several olfactory traits for identifying gene(s) involved in the decline of the sense of smell. Lastly, using available, high quality DNA specimens, I will replicate these genetic associations in NSHAP. A structured training program will include courses in genetic epidemiology and demography for the development of analytic expertise, culminating in a Master's degree. Mentorship will be multidisciplinary by three renowned scientists who possess significant experience in genetics, demography, and aging. This award will allow me to develop the skills necessary to direct an independent research program on the impact of olfactory decline and other nasal diseases on older persons. This approach, utilizing three unparalleled and complementary data sets, will provide insight into the pathophysiology of age-related olfactory decline which, ultimately, can lead to improved prognostic, diagnostic and therapeutic modalities. Completion of these studies will serve as a model for understanding the non- genetic and genetic influences on sensory decline in aging.

描述(由申请人提供)：与年龄相关的嗅觉丧失是一个重要的公共卫生问题，影响着大约1400万美国老年人。这种感官损伤在老年人的日常生活中造成的沉重负担与生活质量的大幅下降有关，影响到安全、营养、快感和总体福祉等关键功能。因为嗅觉会随着时间的推移而下降，临床影响将随着我们人口的老龄化而增加。以前对人类嗅觉生理学下降的研究一直是有限的，需要新的方法来了解影响这一过程的因素。在这一应用中，我建议描述与年龄相关的嗅觉衰退的易感性的因素。利用记忆和老龄化项目(MAP)和国家社会生活、健康和老龄化项目(NSHAP)的数据，我计划确定与年龄相关的嗅觉下降相关的生物统计学因素。这些强大的资源，其中健康和嗅觉数据先前已与相关的生物测量一起收集，将允许分析与老年人嗅觉丧失有关的医学和心理社会参数。同时，我将通过使用MAP和Hutterites中现有的基因数据进行全基因组关联研究(Gwas)来检查这种表型的遗传风险因素，Hutterites是一个在遗传图谱方面具有许多明显优势的群体，包括统一的环境暴露和关于相关共病的丰富临床信息。这项研究将包括对几个嗅觉特征的分析，以确定与嗅觉下降有关的基因(S)。最后，使用可用的、高质量的DNA样本，我将在NSHAP中复制这些遗传关联。一个有组织的培训计划将包括遗传流行病学和人口学方面的课程，以发展分析专业知识，最终获得硕士学位。导师将由三位在遗传学、人口学和老龄化方面拥有丰富经验的著名科学家进行多学科指导。这一奖项将使我能够培养必要的技能，以指导一个关于嗅觉衰退和其他鼻部疾病对老年人的影响的独立研究计划。这种方法，利用三个无与伦比的和互补的数据集，将提供对与年龄相关的嗅觉下降的病理生理学的洞察，最终可能导致改善预后、诊断和治疗方式。这些研究的完成将成为了解衰老过程中非遗传和遗传对感觉衰退的影响的模型。

项目成果

Computer-assisted staging of chronic rhinosinusitis correlates with symptoms.

• DOI: 10.1002/alr.21499
• 发表时间: 2015-07
• 期刊: International forum of allergy & rhinology
• 影响因子: 6.4
• 作者: Garneau J;Ramirez M;Armato SG 3rd;Sensakovic WF;Ford MK;Poon CS;Ginat DT;Starkey A;Baroody FM;Pinto JM
• 通讯作者: Pinto JM

Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray.

• DOI: 10.1186/gb-2007-8-5-r86
• 发表时间: 2007
• 期刊: Genome biology
• 影响因子: 12.3
• 作者: Zhang X;De la Cruz O;Pinto JM;Nicolae D;Firestein S;Gilad Y
• 通讯作者: Gilad Y

Three-dimensional image analysis for staging chronic rhinosinusitis.

• DOI: 10.1002/alr.22014
• 发表时间: 2017-11
• 期刊: International forum of allergy & rhinology
• 影响因子: 6.4
• 作者: Lim S;Ramirez MV;Garneau JC;Ford MK;McKeough K;Ginat DT;Baroody FM;Armato SG 3rd;Pinto JM
• 通讯作者: Pinto JM

Does airway surgery lower serum lipid levels in obstructive sleep apnea patients? A retrospective case review.

• DOI: 10.12659/msm.892230
• 发表时间: 2014-12-13
• 期刊: Medical science monitor : international medical journal of experimental and clinical research
• 作者: Li L;Zhan X;Wang N;Pinto JM;Ge X;Wang C;Tian J;Wei Y
• 通讯作者: Wei Y

Rhinitis in the geriatric population.

老年人群中的鼻炎。

• DOI: 10.1186/1710-1492-6-10
• 发表时间: 2010
• 期刊: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
• 作者: Pinto,JayantM;Jeswani,Seema
• 通讯作者: Jeswani,Seema