Integrin intracellular transport, expression and function in macrophages regulates inflammation during wound healing

巨噬细胞中整合素的细胞内转运、表达和功能调节伤口愈合过程中的炎症

• 批准号: nhmrc : 512259
• 负责人: Dr Rachael Murray
• 金额: $ 28.95万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/integrin-intracellular-transport-wound-healing/77075
• 关键词: Integrin; intracellular; transport; expression; function

Burns are one of the most common and devastating forms of trauma; 70% occur in young children. Burns scars may be aesthetically disfiguring and functionally disabling, as well as psychosocially damaging. The study will identify how macrophages enter, function and persist in a burn wound to regulate inflammation, which if prolonged results in delayed healing and excess scar formation, and will generate multiple targets for potential future wound healing therapies.

烧伤是最常见和最具破坏性的创伤形式之一; 70%发生在幼儿身上。烧伤疤痕可能会在美学上毁容和功能残疾，以及心理社会损害。该研究将确定巨噬细胞如何进入，发挥作用并持续存在于烧伤伤口中以调节炎症，如果长时间导致延迟愈合和过度瘢痕形成，并将为未来潜在的伤口愈合治疗产生多个目标。