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Mentoring and Research in Placebo Studies, Asian Medicine, and CAM

安慰剂研究、亚洲医学和 CAM 的指导和研究

基本信息

批准号：
8642138
负责人：
Ted Kaptchuk
金额：
$ 15.29万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8642138
关键词：
Achievement Acupuncture procedure Antibodies Area Asians Asthma Authorship Autoantibodies Award Basic Science Belief Bioethics Biological Brain Caring Chronic Chronic low back pain Clinical Clinical Research Clinical Sciences Commit Complementary and alternative medicine Cues Degenerative polyarthritis Discipline Disease Doctor&apos s Degree Expectancy Fellowship Program Fostering Functional Magnetic Resonance Imaging Funding Future Future Generations Genes Genetic Polymorphism Goals Healthcare Humanities Imagination Immunology Inflammation Mediators Intervention Irritable Bowel Syndrome Ketorolac Knee Osteoarthritis Magnetic Resonance Imaging Major Depressive Disorder Mediator of activation protein Medical Medicine Mental Depression Mentors Methods MicroRNAs Mid-Career Clinical Scientist Award (K24)Migraine Modeling Molecular Molecular Analysis Morphine National Center for Complementary and Alternative Medicine Neurobiology Neurosciences Research Outcome Pain Pain Disorder Pathway interactions Patients Peer Review Philosophy Physician-Patient Relations Physicians Placebo Effect Placebos Positron-Emission Tomography Principal Investigator Process Progress Reports Provider Prunella vulgaris Publications Publishing Regulation Reporting Research Research Design Research Personnel Research Project Grants Ritual compulsion Role Sampling Scholarship Science Scientist Serum Single Nucleotide Polymorphism Social Sciences Structure System Teaching Hospitals Technology Testing Therapeutic Studies Time Training Translational Research Trust United States National Institutes of Health Universities Work base chronic pain classical conditioning clinical care clinically relevant conditioning cytokine expectation experience flexibility healthy volunteer interest medical schools neural circuit neuroimaging next generation open label prevent professor programs public health relevance research study response restraint social statistics

项目摘要

DESCRIPTION (provided by applicant): Four years ago, Professor Kaptchuk, OMD, received a Midcareer K24 award. This is a renewal application. The principal investigator's short-term goal is to obtain protected time to 1) stabilize and expand his training of the next generation of CAM scientists and 2) develop a multi-disciplinary research program in placebo, East Asian medicine and complementary and alternative medicine (CAM). His long-term goal, for his work and that of his trainees, is to make clinically relevant contributions to clinical care. Ted Kaptchk is Associate Professor of Medicine at Harvard Medical School. His research and scholarship integrates concepts, research designs and analytic methods drawn from the basic, clinical, and social sciences, as well as the humanities. Achievements in first four years of K24: The principal investigator has completed three major RCTs investigating placebo effects and two RCTs testing acupuncture's efficacy. He also performed groundbreaking studies identifying the brain circuitry of responses to placebo and acupuncture. In this period, the principal investigator published 70 articles, eight as first author and 28 as senior author. The principal investigator also received two new R01s concerned with both placebo/expectation effects and acupuncture and, as senior co-investigator, a P01, U19 and various R21s. During the initial K24 period, he has been primary or co-primary CAM mentor for 25 trainees with doctoral degrees. Eleven trainees held K training awards. His trainees authored 53 first-authored peer-reviewed publications and had 82 co-authorships. He expects to expand these successful efforts in a renewal period. Harvard University and its 17 teaching hospitals comprise an NIH affiliated CTSA institutional consortium. Professor Kaptchuk is fully integrated into the CTSA and has recently been appointed director of Harvard-wide Program in Placebo Studies and Therapeutic Encounter. He is active in many Harvard fellowship programs including serving as associate director of the Harvard-wide NCCAM-funded T32 CAM fellowship program. The principal investigator will take relevant courses in bioethics, philosophy of science, immunology, and statistics and engage in hands-on training in molecular and neuroimaging research. In the first four years of his K24, the principal investigator developed a research portfolio that includes translational research in irritable bowel syndrome, asthma, depression, osteoarthritis, and migraine. These research areas will be expanded. He is currently using fMRI to extend his previous work on the neural circuitry of placebo and acupuncture in healthy volunteers to patients with chronic pain disorders. A PET-fMRI study will investigate placebo responses dependent on morphine conditioning verses ketorolac conditioning. He will initiate fMRI experiments to elucidate the neurobiology of the physician component of the patient-physician relationship. The principal investigator is also investigating specific biological pathways implicated in placebo and acupuncture responses and their mechanisms of regulation by concurrently examining circulating serum cytokines, auto antibodies, microRNAs and polymorphisms (SNPs) in genes of interest.

描述（由申请人提供）：四年前，Kaptchuk教授获得了职业生涯中期K24奖。这是续订申请。首席研究员的短期目标是获得保护时间，以1)稳定和扩大他对下一代CAM科学家的培训，2)在安慰剂、东亚医学和补充和替代医学（CAM）方面开展多学科研究项目。他的长期目标，对于他的工作和他的学员来说，是对临床护理做出临床相关的贡献。Ted Kaptchk是哈佛医学院的医学副教授。他的研究和学术融合了基础科学、临床科学、社会科学和人文科学的概念、研究设计和分析方法。K24头四年的成果：主要研究者完成了三个主要的随机对照试验，研究安慰剂效应，两个测试针灸疗效。他还进行了开创性的研究，确定了安慰剂和针灸对大脑回路的反应。在此期间，主要研究者发表了70篇论文，其中第一作者8篇，高级作者28篇。首席研究员还接受了两个新的r01，涉及安慰剂/预期效应和针灸，并作为高级共同研究者，接受了P01， U19和各种r21。在K24项目初期，他担任了25名博士学位学员的主要或共同主要CAM导师。11名学员获得了K培训奖。他的学员发表了53篇同行评议的第一作者论文，并有82篇合著论文。他希望在复兴时期扩大这些成功的努力。哈佛大学及其17所教学医院组成了一个隶属于NIH的CTSA机构联盟。Kaptchuk教授完全融入了CTSA，最近被任命为哈佛大学安慰剂研究和治疗遭遇项目的主任。他活跃于许多哈佛奖学金项目，包括担任哈佛范围内nccam资助的T32 CAM奖学金项目的副主任。首席研究员将学习生物伦理学、科学哲学、免疫学和统计学等相关课程，并参与分子和神经影像学研究方面的实践培训。在K24的头四年里，首席研究员开发了一个研究组合，包括肠易激综合征、哮喘、抑郁症、骨关节炎和偏头痛的转化研究。这些研究领域将不断扩大。目前，他正在使用功能磁共振成像技术，将他之前在健康志愿者身上的安慰剂和针灸的神经回路研究扩展到慢性疼痛障碍患者身上。一项PET-fMRI研究将调查依赖于吗啡条件和酮罗拉酸条件的安慰剂反应。他将启动功能磁共振实验来阐明医患关系中医生成分的神经生物学。首席研究员还通过同时检测循环血清细胞因子、自身抗体、microrna和感兴趣基因的多态性（snp），研究安慰剂和针灸反应中涉及的特定生物学途径及其调节机制。