Dimensions of Oral Health-Related Quality of Life

口腔健康相关生活质量的维度

• 批准号: 8668770
• 负责人: Mike John
• 金额: $ 59.68万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8668770
• 关键词: Adult; Affect; Aftercare; Age; American; Area; Centers for Disease Control and Prevention (U.S.); Chemotherapy-Oncologic Procedure; Childhood; Chronic; Chronic low back pain; Clinical; Computers; Country; Data; Data Set; Decision Making; Dental; Dental General Practice; Dental Research; Dental caries; Dentistry; Dentists; Development; Dimensions; Disease; Ensure; Evaluation; Expert Opinion; Factor Analysis; General Population; Goals; Government Agencies; Health; Healthcare Systems; Individual; Information Systems; Intervention; Lead; Length; Measurable; Measurement; Measures; Methodology; Metric; Minnesota; Musculoskeletal; Oral; Oral Health Impact Profile; Oral Ulcer; Oral cavity; Oral health; Orofacial Pain; Outcome; Outcome Measure; Pain; Patient Care; Patient Outcomes Assessments; Patient Self-Report; Patients; Perception; Personal Satisfaction; Population; Practice based research; Process; Quality of Care; Quality-of-Life Assessment; Questionnaires; Recruitment Activity; Research; Research Personnel; Resources; Sampling; Structure; Surgeon; Temporomandibular Joint Disorders; Testing; Tooth structure; Validation; Work; Xerostomia; alternative treatment; base; clinical practice; comparative effectiveness; cost; design; disability; health related quality of life; improved; instrument; oral condition; oral pain; population health; response; screening; sound; theories; tool; treatment effect

DESCRIPTION (provided by applicant): In both dental research and clinical practice, how patients perceive the effects of dental interventions is essential, and one standard instrument should exist to measure and compare these effects. Here, oral health- related quality of life (OHRQoL) is the most promising concept. The most widely used OHRQoL instrument for adults, the 49-item Oral Health Impact Profile (OHIP), combines items into 7 scores that putatively measure 7 latent dimensions of perceived oral health. This set of 7 scores has been used for almost 20 years but has never been validated. In fact, recent evidence indicates that the OHIP dimensional structure is not correct, which creates a fundamental measurement problem for the assessment of OHRQoL using OHIP. The major goals of this proposal are (i) to determine which OHRQoL dimensions exist and to derive a new OHIP dimensional structure, (ii) to derive 2 new OHIP short forms and a computer adaptive testing version based on these revised dimensions, and (iii) to validate the revised OHIP dimensional structure and the newly derived versions. Existing OHIP data from 6,628 general-population subjects and 2,502 dental patients from 6 countries will be used both to derive revised OHIP dimensions by applying factor analysis and to test the newly identified dimensions. In addition, 2 new shorter OHIP forms and a computer adaptive testing version (all aimed at reducing self-reporting burden) will be developed using item response theory. Finally, a new sample of 2,000 dental patients in Minnesota will be used to validate the derived OHIP dimensions and new OHIP forms in cross-sectional and longitudinal analyses using other measures of self-reported oral health and clinical oral-health indicators. During the validation process, items from 2 other OHRQoL instruments will be integrated into the instrument to create one standard OHRQoL instrument. A unified framework for OHRQoL assessment based on OHIP will be created, and methodologies such as item response theory and bifactor analysis will ensure that scores from newly derived short-form OHIP versions are compatible with scores from longer OHIPs (score equating). The relationship of OHIP scores to health-related quality of life outcome measures will be explored using methodology from NIH's Patient-Reported Outcomes Measurement Information System (PROMIS). The revised OHIP will measure perceived oral health with a valid set of OHIP dimension scores from instruments with different lengths that will nevertheless be compatible across settings. A profile of sound OHIP dimension scores can become dentistry's standard tool for assessing oral health and treatment effects from the patient's perspective. The revised OHIP will allow effects from all oral interventions to become comparable, aiding dentists and patients in their evaluation of treatment alternatives and informing health care systems for setting resource priorities.

描述（由申请人提供）：在牙科研究和临床实践中，患者如何感知牙科干预的效果是至关重要的，应该有一个标准的工具来测量和比较这些效果。在这里，口腔健康相关的生活质量（OHRQoL）是最有前途的概念.最广泛使用的成人OHRQoL工具，49项口腔健康影响概况（OHIP），将项目组合成7个分数，可以测量感知口腔健康的7个潜在维度。这套7分的评分已经使用了近20年，但从未得到验证。事实上，最近的证据表明，OHIP的维度结构是不正确的，这创造了一个基本的测量问题，使用OHIP的OHRQoL的评估。本提案的主要目标是（i）确定存在哪些OHRQoL维度，并推导出新的OHIP维度结构，（ii）推导出2种新的OHIP简表和基于这些修订维度的计算机自适应测试版本，以及（iii）验证修订的OHIP维度结构和新推导的版本。来自6个国家的6，628名普通人群受试者和2，502名牙科患者的现有OHIP数据将用于通过应用因子分析得出修订的OHIP维度，并测试新确定的维度。此外，还将使用项目反应理论开发两种新的较短的OHIP表格和一种计算机自适应测试版本（均旨在减少自我报告负担）。最后，将使用明尼苏达州2，000名牙科患者的新样本，使用自我报告的口腔健康和临床口腔健康指标的其他指标，在横断面和纵向分析中验证推导出的OHIP维度和新的OHIP形式。在确认过程中，将其他2个OHRQoL仪器的项目整合到仪器中，以创建一个标准OHRQoL仪器。将建立一个基于OHIP的OHRQoL评估的统一框架，项目反应理论和双因素分析等方法将确保新得出的简短OHIP版本的分数与较长OHIP版本的分数兼容（分数相等）。OHIP评分与健康相关生活质量结局指标的关系将使用NIH患者报告结局测量信息系统（PROMIS）的方法进行探讨。修订后的OHIP将测量感知口腔健康与一组有效的OHIP维度得分的工具，具有不同的长度，但将跨设置兼容。一个健全的OHIP维度分数的配置文件可以成为牙科的标准工具，从患者的角度评估口腔健康和治疗效果。修订后的OHIP将允许所有口腔干预措施的效果变得可比，帮助牙医和患者评估治疗方案，并告知医疗保健系统设置资源优先级。