Allergens and Induced Asthma: Eradicating Indoor Allergens from Dust Mites (Phase

描述（由申请人提供）：CarboNix LLC的使命是临床有效地减少引起过敏反应和经常诱发哮喘的常见室内过敏原，特别是在经济困难的儿童中。CarboNix LLC提出了一项二期SBIR研究计划，该计划将导致一项新的服务业务的商业化，该业务旨在减少多种室内过敏原，杀死尘螨，并防止螨在家中再次感染。在预商业化阶段提出了两个具体目标。具体目标1是计算机建模，设计和测试一个全面的家庭服务单元，以减少过敏原。具体目标2是对该技术进行为期12个月的实地测试，比较接受治疗的家庭与未接受治疗的家庭的过敏原水平和尘螨水平。尘螨是仅次于花粉的过敏源。反应范围从鼻子和眼睛发痒到严重的，有时甚至致命的哮喘发作。这对13岁以下的儿童尤其重要。这个项目可以使过敏患者受益，但特别针对少数民族和低收入儿童，他们死于尘螨过敏原诱发的哮喘的可能性是常人的六倍。美国肺脏协会估计，每年有3250万美国人11.2%)被诊断患有哮喘，其中620万是5至17岁的儿童。研究表明，大多数哮喘加重儿童暴露于高水平的室内过敏原，持续暴露可导致再入院。美国国家卫生统计中心显示，少数族裔儿童（特别是非洲裔美国人和波多黎各人）患哮喘的比例比白人儿童高40%。我们将为家庭及其过敏症专家创建一项新的服务业务，在操作和成本上类似于地毯清洁服务；Namel，去除广泛的室内过敏原和根除尘螨从家庭环境。临床医生通常采用多种干预策略进行过敏和哮喘管理。这项新业务将为临床医生提供一种新的介入工具，即安全、廉价地清洁含有过敏原的家居用品。

DESCRIPTION (provided by applicant): The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induce asthma, especially in economically-disadvantaged children. CarboNix LLC proposes a Phase II SBIR research program that will result in commercialization of a new service business for abating multiple indoor allergens, killing dust mites, and preventing mite re-infestation in the home. Two specific aims are proposed at the pre-commercialization state. Specific Aim 1 is the computer modeling, design, and testing of a full-scale home service unit for allergen abatement. Specific Aim 2 is a twelve-month field test of the technology, comparing the allergen levels and dust mite levels in treated homes to non-treated homes. The dust mite is second only to pollen in causing allergies. Reactions range from itchy noses and eyes to severe and sometimes fatal asthma attacks. This is especially critical in children under age 13. This project could benefit an allergy sufferer, but is specifically aimed at minority and low-income children who are six times more likely to die from dust mite allergen-induced asthma. The American Lung Association estimates that 32.5 million Americans (approx. 11.2%) have been diagnosed with asthma, and 6.2 million of these are children between 5 and 17. It has been shown that most children with exacerbation of asthma have been exposed to high levels of indoor allergens, and that continuous exposure can result in readmission. The National Center for Health Statistics showed that the prevalence of asthma in minority (specifically African American and Puerto Rican) children is 40% higher than in white children. We will create a new service business, similar in operation and cost to carpet cleaning services, for families and their allergists; namel, removal of a broad spectrum of indoor allergens and eradication of dust mites from the home environment. Clinicians often employ a multiple-intervention strategy for allergy and asthma management. The new business will give practicing clinicians a new interventional tool, namely the safe and inexpensive cleaning of allergen-laden household items.