Allergens and Induced Asthma: Eradicating Indoor Allergens from Dust Mites (Phase

过敏原和诱发哮喘：消除室内尘螨过敏原（阶段

• 批准号: 8524707
• 负责人: Allan M. Quick
• 金额: $ 55.3万
• 依托单位: CARBONIX, LLC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-25 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8524707
• 关键词: Abate; African American; Age; Agitation; Air; Allergens; Allergic; Allergic Reaction; American; American Lung Association; Asthma; Businesses; Carpet; Child; Computer Simulation; Data; Diagnosis; Disadvantaged; Disease; Dry Ice; Economically Deprived Population; Economics; Engineering; Enrollment; Equipment; Excision; Eye; Family; Feces; Felis catus; Gases; Heating; Home environment; Household; Housing; Hypersensitivity; Intervention; Intervention Studies; Laboratories; Larva; Liquid substance; Longitudinal Studies; Low income; Mattresses; Measurement; Minority; Mission; Mites; Modeling; Nose; Nymph; Patients; Pest Control; Pharmaceutical Preparations; Phase; Pollen; Power Sources; Prevalence; Prevention; Process; Proteins; Puerto Rican; Reaction; Recruitment Activity; Research; Safety; Sampling; Seasonal Variations; Services; Small Business Innovation Research Grant; Source; Speed; Suction; Surface; System; Technology; Temperature; Testing; Textiles; Time; TimeLine; United States National Center for Health Statistics; Vacuum; Validation; acaricide; base; commercialization; cost; design; design and construction; egg; extreme temperature; fighting; killings; model design; new technology; novel; operation; prevent; programs; prototype; public health relevance; pyroglyphid; response; tool

DESCRIPTION (provided by applicant): The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induce asthma, especially in economically-disadvantaged children. CarboNix LLC proposes a Phase II SBIR research program that will result in commercialization of a new service business for abating multiple indoor allergens, killing dust mites, and preventing mite re-infestation in the home. Two specific aims are proposed at the pre-commercialization state. Specific Aim 1 is the computer modeling, design, and testing of a full-scale home service unit for allergen abatement. Specific Aim 2 is a twelve-month field test of the technology, comparing the allergen levels and dust mite levels in treated homes to non-treated homes. The dust mite is second only to pollen in causing allergies. Reactions range from itchy noses and eyes to severe and sometimes fatal asthma attacks. This is especially critical in children under age 13. This project could benefit an allergy sufferer, but is specifically aimed at minority and low-income children who are six times more likely to die from dust mite allergen-induced asthma. The American Lung Association estimates that 32.5 million Americans (approx. 11.2%) have been diagnosed with asthma, and 6.2 million of these are children between 5 and 17. It has been shown that most children with exacerbation of asthma have been exposed to high levels of indoor allergens, and that continuous exposure can result in readmission. The National Center for Health Statistics showed that the prevalence of asthma in minority (specifically African American and Puerto Rican) children is 40% higher than in white children. We will create a new service business, similar in operation and cost to carpet cleaning services, for families and their allergists; namel, removal of a broad spectrum of indoor allergens and eradication of dust mites from the home environment. Clinicians often employ a multiple-intervention strategy for allergy and asthma management. The new business will give practicing clinicians a new interventional tool, namely the safe and inexpensive cleaning of allergen-laden household items.

描述(申请人提供)：CarboNix LLC的使命是在临床上有效地减少引起过敏反应和经常导致哮喘的常见室内过敏原，特别是在经济困难的儿童中。CarboNix LLC提出了一项第二阶段的SBIR研究计划，这将导致一项新的服务业务的商业化，该业务旨在减少多种室内过敏原，杀灭尘螨，并防止尘螨在家中再次感染。针对预商业化状态，提出了两个具体目标。具体目标1是用于减少过敏原的全尺寸家庭服务单元的计算机建模、设计和测试。具体目标2是对这项技术进行为期12个月的现场测试，比较经过治疗的家庭和未接受治疗的家庭中的过敏原水平和尘螨水平。在引起过敏方面，尘螨仅次于花粉。反应范围从鼻子和眼睛发痒到严重的、有时是致命的哮喘发作。这在13岁以下的儿童中尤其重要。该项目可能会让过敏患者受益，但专门针对少数族裔和低收入儿童，他们死于尘螨过敏原引起的哮喘的可能性是他们的六倍。美国肺脏协会估计，3250万美国人(约11.2%)被诊断为哮喘，其中620万是5至17岁的儿童。已有研究表明，大多数哮喘加重的儿童暴露在高水平的室内过敏原中，持续暴露可导致再次入院。国家卫生统计中心显示，少数族裔(特别是非洲裔美国人和波多黎各人)儿童的哮喘患病率比白人儿童高40%。我们将创建一项新的服务业务，其运营和成本类似于地毯清洁服务，为家庭及其过敏症专科医生提供服务；Namel，去除广泛的室内过敏原，并根除家庭环境中的尘螨。临床医生经常采用多重干预策略来管理过敏和哮喘。这项新业务将为执业临床医生提供一种新的干预工具，即安全且廉价地清洁含有过敏原的家用物品。