Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites

过敏原和诱发哮喘：根除室内过敏原和尘螨

• 批准号: 8058379
• 负责人: Allan M. Quick
• 金额: $ 12.98万
• 依托单位: CARBONIX, LLC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-25 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8058379
• 关键词: African American; Age; Allergens; Allergic Reaction; American; American Lung Association; Appearance; Area; Asthma; Bathing; Beds; Businesses; Carbon Dioxide; Carpet; Child; Color; Dermatophagoides pteronyssinus antigen p 1; Devices; Diagnosis; Disadvantaged; Dry Ice; Dust; Effectiveness; Environment; Equipment; Excision; Eye; Family; Feces; Food; Home environment; Household; Human; Hypersensitivity; Implant; Intervention; Laboratories; Larva; Life; Liquid substance; Low income; Maintenance; Mattresses; Measures; Microscopy; Minority; Mission; Mites; Nose; Nymph; Phase; Pollen; Population; Prevalence; Process; Proteins; Puerto Rican; Reaction; Recycling; Research; Research Proposals; Residual state; Sampling; Services; Skin; Solutions; Suction; Surface; System; Technology; Temperature; Testing; Textiles; Texture; Time; United States National Center for Health Statistics; Vacuum; acaricide; commercialization; cost; egg; extreme temperature; implantation; injured; innovation; killings; novel; novel strategies; operation; particle; pet animal; prevent; programs; pyroglyphid; repository; sublimation; success; tool; wasting

DESCRIPTION (provided by applicant): Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induce asthma, especially in children. The focus of this project is on the dust mite. Carbonix LLC proposes a Phase I research program, leading to a commercialization of a new service business for killing dust mites in the home and preventing re-infestation. Three specific aims are proposed to demonstrate feasibility. Specific Aim 1 will demonstrate that treating carpets with our proprietary technology will physically kill dust mites. Specific Aim 2 will demonstrate that an acaricide can be incorporated in the process, penetrating carpeting and preventing mite re-infestation. Specific Aim 3 will demonstrate the Carbonix process on mattresses, the other main repository of mites in the home. The dust mite is second only to pollen in causing allergies. Reactions range from itchy noses and eyes to severe and sometimes fatal asthma attacks. This is especially critical in children under age 13. This project could benefit any allergy sufferer, but is specifically aimed at minority and low-income children who are six times more likely to die from dust mite allergen-induced asthma. The American Lung Association estimates that 32.5 million Americans (approx. 11.2%) have been diagnosed with asthma, and 6.2 million of these are children between 5 and 17. It has been shown that most children with exacerbation of asthma have been exposed to high levels of indoor allergens, and that continuous exposure can result in readmission. The National Center for Health Statistics showed that the prevalence of asthma in minority (specifically African American and Puerto Rican) children is 40% higher than in white children. We will create a new service business, similar in operation and cost to carpet cleaning services, for families and their allergists; namely, complete removal and deactivation of dust mites from the home environment. Clinicians often employ a multiple-intervention strategy for allergy and asthma management. The new business will give practicing clinicians a new interventional tool, namely the safe and inexpensive cleaning of allergen- laden household items. PUBLIC HEALTH RELEVANCE: Eradication of Dust Mites and Removal of Allergens in Carpeting Asthma is a killer of children; especially those from disadvantaged homes. Many asthma attacks, especially in children, are triggered by the allergenic proteins found in dust mite feces. The proposed research focuses on a novel, clean, safe and effective approach to eradicating dust mites in carpeting and other large fabric surfaces.

描述（由申请人提供）：过敏原和诱发哮喘：消除室内过敏原和尘螨CarboNix LLC的使命是临床有效地消除引起过敏反应和经常诱发哮喘的常见室内过敏原，特别是儿童。该项目的重点是尘螨。碳有限责任公司提出了一个第一阶段的研究计划，导致商业化的一个新的服务业务，杀死尘螨在家里，并防止再次感染。提出了三个具体目标来证明可行性。具体目标1将证明用我们的专有技术处理地毯将物理杀死尘螨。具体目标2将证明，杀螨剂可以纳入该过程中，渗透地毯和防止螨再次侵染。具体目标3将展示碳过程中的床垫，另一个主要的储存库螨在家里。尘螨是仅次于花粉的第二大过敏原。反应范围从鼻子和眼睛发痒到严重的，有时是致命的哮喘发作。这对13岁以下的儿童尤其重要。该项目可以使任何过敏患者受益，但特别针对少数民族和低收入儿童，他们死于尘螨过敏原引起的哮喘的可能性是其他儿童的六倍。美国肺脏协会估计，3250万美国人（约100万人）11.2%）被诊断患有哮喘，其中620万是5至17岁的儿童。研究表明，大多数哮喘急性发作的儿童暴露于高水平的室内过敏原，持续暴露可导致再次入院。国家卫生统计中心显示，少数民族（特别是非洲裔美国人和波多黎各人）儿童的哮喘患病率比白色儿童高40%。我们将为家庭及其过敏症专科医生创造一种新的服务业务，其操作和成本与地毯清洁服务相似;即从家庭环境中完全清除和灭活尘螨。临床医生经常采用多种干预策略来管理过敏和哮喘。新业务将为执业临床医生提供一种新的介入工具，即安全廉价地清洁充满过敏原的家居用品。 公共卫生关系：在地毯中消灭尘螨和去除过敏原哮喘是儿童的杀手，特别是那些来自贫困家庭的儿童。许多哮喘发作，特别是儿童，是由尘螨粪便中发现的过敏蛋白引发的。拟议的研究重点是一种新颖，清洁，安全和有效的方法来消除地毯和其他大型织物表面的尘螨。