Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites

描述（由申请人提供）：过敏原和诱发哮喘：根除室内过敏原和尘螨CarboNix LLC的使命是临床有效地减少引起过敏反应和经常诱发哮喘的常见室内过敏原，特别是在儿童中。这个项目的重点是尘螨。Carbonix LLC提出了一项I期研究计划，导致一项新的服务业务的商业化，该业务可以杀死家中的尘螨并防止再次感染。提出了三个具体目标来论证可行性。具体目标1将证明，用我们的专有技术处理地毯将物理杀死尘螨。具体目标2将证明在这一过程中可以加入杀螨剂，穿透地毯并防止螨虫再次侵袭。具体目标3将演示床垫上的Carbonix过程，床垫是家中螨虫的另一个主要储存库。尘螨是仅次于花粉的过敏源。反应范围从鼻子和眼睛发痒到严重的，有时甚至致命的哮喘发作。这对13岁以下的儿童尤其重要。这个项目可以使任何过敏患者受益，但特别针对少数民族和低收入儿童，他们死于尘螨过敏原诱发的哮喘的可能性是常人的六倍。美国肺脏协会估计，每年有3250万美国人11.2%)被诊断患有哮喘，其中620万是5至17岁的儿童。研究表明，大多数哮喘加重儿童暴露于高水平的室内过敏原，持续暴露可导致再入院。美国国家卫生统计中心显示，少数族裔儿童（特别是非洲裔美国人和波多黎各人）患哮喘的比例比白人儿童高40%。我们将为家庭及其过敏症专家创建一项新的服务业务，在操作和成本上类似于地毯清洁服务；也就是说，从家庭环境中完全去除和灭活尘螨。临床医生通常采用多种干预策略进行过敏和哮喘管理。这项新业务将为临床医生提供一种新的介入工具，即安全、廉价地清洁含有过敏原的家居用品。

DESCRIPTION (provided by applicant): Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induce asthma, especially in children. The focus of this project is on the dust mite. Carbonix LLC proposes a Phase I research program, leading to a commercialization of a new service business for killing dust mites in the home and preventing re-infestation. Three specific aims are proposed to demonstrate feasibility. Specific Aim 1 will demonstrate that treating carpets with our proprietary technology will physically kill dust mites. Specific Aim 2 will demonstrate that an acaricide can be incorporated in the process, penetrating carpeting and preventing mite re-infestation. Specific Aim 3 will demonstrate the Carbonix process on mattresses, the other main repository of mites in the home. The dust mite is second only to pollen in causing allergies. Reactions range from itchy noses and eyes to severe and sometimes fatal asthma attacks. This is especially critical in children under age 13. This project could benefit any allergy sufferer, but is specifically aimed at minority and low-income children who are six times more likely to die from dust mite allergen-induced asthma. The American Lung Association estimates that 32.5 million Americans (approx. 11.2%) have been diagnosed with asthma, and 6.2 million of these are children between 5 and 17. It has been shown that most children with exacerbation of asthma have been exposed to high levels of indoor allergens, and that continuous exposure can result in readmission. The National Center for Health Statistics showed that the prevalence of asthma in minority (specifically African American and Puerto Rican) children is 40% higher than in white children. We will create a new service business, similar in operation and cost to carpet cleaning services, for families and their allergists; namely, complete removal and deactivation of dust mites from the home environment. Clinicians often employ a multiple-intervention strategy for allergy and asthma management. The new business will give practicing clinicians a new interventional tool, namely the safe and inexpensive cleaning of allergen- laden household items. PUBLIC HEALTH RELEVANCE: Eradication of Dust Mites and Removal of Allergens in Carpeting Asthma is a killer of children; especially those from disadvantaged homes. Many asthma attacks, especially in children, are triggered by the allergenic proteins found in dust mite feces. The proposed research focuses on a novel, clean, safe and effective approach to eradicating dust mites in carpeting and other large fabric surfaces.