Improving Long-Term Outcomes Clinical Research for Acute Respiratory Failure

改善急性呼吸衰竭的长期结果临床研究

• 批准号: 8700491
• 负责人: Dale Murray Needham
• 金额: $ 125.11万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8700491
• 关键词: Acute; Acute Lung Injury; Acute respiratory failure; Address; Adult Respiratory Distress Syndrome; Advisory Committees; Area; Cessation of life; Clinical Research; Clinical Trials Design; Cognitive; Consensus; Critical Care; Data Set; Databases; Dependency; Development; Educational workshop; Effectiveness; Foundations; Goals; Grant; Health; Health Care Costs; Hour; Impaired cognition; Impairment; Institutes; Intensive Care Units; Internet; Knowledge; Leadership; Long-Term Survivors; Measurement; Measures; Mechanical ventilation; Mental Health; Methodology; Methods; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Online Systems; Outcome; Outcome Measure; Outcome Study; Outcomes Research; Participant; Patients; Phase III Clinical Trials; Physical Function; Process; Public Health; Publications; Reporting; Research; Research Personnel; Resources; Societies; Solid; Speed; Staging; Statistical Methods; Structure; Surveys; Survivors; Uncertainty; Universities; Work; abstracting; aging population; analytical method; cohort; comparative effectiveness; depressive symptoms; effectiveness research; experience; follow-up; functional outcomes; improved; instrument; interest; mortality; neuromuscular; patient safety; programs; public health relevance; research clinical testing; research study; systematic review

DESCRIPTION (provided by applicant): With the aging population, there is a growing number of intensive care unit (ICU) patients with acute lung injury/acute respiratory distress syndrome (ALI) and other causes of acute respiratory failure (ARF). Advances in critical care have decreased ICU patients' mortality, but survivors frequently have substantial post-ICU physical, cognitive and mental health morbidities, which can last for years after discharge. A recent NHLBI workshop recommended that long-term outcomes be a fundamental part of all Phase III trials and indicated a need for determining appropriate measures for ALI/ARF survivors. At present, there is great uncertainty regarding which measurement instruments and analytical methods to use and how to effectively retain a cohort of ALI/ARF survivors for long-term follow-up. The overall goal of this grant is to create and nationally disseminate resources to assist ALI/ARF researchers with designing trials that appropriately evaluate long-term patient outcomes through creating and nationally disseminating: (a) a web-based electronic database of recommended survey instruments and clinical testing methods for evaluating survivors' long-term physical, cognitive and mental health outcomes (Aim 1), (b) resources for maximizing retention of survivors in long-term, longitudinal research studies (Aim 2), and (c) appropriate statistical analysis methods and programs to address "censoring due to death" which occurs when evaluating longitudinal functional outcomes in the setting of high patient mortality (Aim 3). This grant will utilize several methos for creating these resources, including: (a) rigorous systematic reviews, (b) empirical analyses using unique existing datasets, and, (c) structured expert consensus processes. For national dissemination of the resources, the grant will exploit the investigators' expertise in disseminatio methodology and their access and leadership within several existing national networks of relevant users of these clinical research resources.

描述（由申请人提供）：