Mid-Career Mentoring Award for Patient-Oriented Research in Aging

项目摘要/摘要： 我，爱德华·R·马尔坎托尼奥，医学博士，SM，是一名获得委员会认证的老年病学家，以患者为导向的衰老研究人员， 哈佛医学院(HMS)医学副教授兼 贝丝以色列女执事医疗中心(BIDMC)的普通医学和初级保健。从长远来看 我的职业目标是进行以患者为中心的研究(POR)，以提高护理质量和 住院老年人的结果，并为对POR感兴趣的新研究人员提供指导 衰老。在过去的16年里，我建立了一个成功的、独立的、由NIH资助的研究项目 重点关注精神错乱(急性精神错乱)，这是住院老年人的一种常见、病态和代价高昂的疾病。我 进行了一系列观察性和干预性研究，旨在提高诊断、靶向 处于危险中的个人，识别可改变的风险因素，并测试干预策略以减少发病率， 精神错乱的严重程度和持续时间。通过这些学习，我获得了必要的知识和技能 进行高质量的POR并指导新的调查人员，并因我在 获得了两个享有盛誉的奖项。在此背景下，这个K24奖项的主要目标是： 1.继续围绕改善住院护理的质量和结果建立研究方案 患有精神错乱的老年人。这一目标将通过我目前获得资助的研究来实现，包括 NIA资助的R01，题为3D-CAM：推导和验证Delirium的3分钟诊断评估， 我的新研究，一个Delirium的Biomarker发现项目，在这份申请中描述了。收据： K24将使我能够更有效地利用这些研究和其他正在进行的工作来支持 实习生，他们将反过来扩大我的研究项目。 2.建立一个导师计划，扩大BIDMC和HMS在老龄化方面的POR，重点是精神错乱 以及相关的条件。这一目标将通过有组织的、个人的青年导师来实现。 对POR有浓厚兴趣的调查人员。K24奖将提供受保护的指导时间。 3.扩大我的导师计划，将围绕BioMarker的翻译、跨学科工作包括在内 发现精神错乱，并应用生物标记物改善风险分层、诊断和预测 患有精神错乱的老年人。这一目标将通过我的新研究项目--职业生涯来实现 发展活动，以及跨学科合作，将通过获得K24奖而得到促进。 一流的学术环境和优秀的机构将极大地促进我的目标 HMS和BIDMC普通医学和老年学分部提供的支持。

PROJECT SUMMARY/ABSTRACT: I, Edward R. Marcantonio, MD, SM, am a board-certified geriatrician and patient-oriented aging researcher, Associate Professor of Medicine at Harvard Medical School (HMS) and Director of Research in the Division of General Medicine and Primary Care at Beth Israel Deaconess Medical Center (BIDMC). The long term objectives of my career are to conduct patient-oriented research (POR) to improve the quality of care and outcomes of hospitalized older adults, and to provide mentoring to new investigators interested in POR in aging. Over the past 16 years, I have built a successful, independent, NIH-funded program of research focused on delirium (acute confusion), a common, morbid and costly condition in hospitalized older adults. I have conducted a series of observational and interventional studies designed to improve diagnosis, target individuals at risk, identify modifiable risk factors, and test intervention strategies to reduce the incidence, severity and duration of delirium. Through these studies, I have gained the knowledge and skills necessary to conduct high quality POR and to mentor new investigators, and have been recognized for my excellence in mentoring with two prestigious awards. In this context, the primary objectives of this K24 Award are: 1. To continue to build a research program around improving the quality and outcomes of care for hospitalized older adults with delirium. This objective will be accomplished through my currently funded studies, including an NIA-funded R01 entitled 3D-CAM: Deriving and validating a 3-Minute Diagnostic Assessment for Delirium, and my new research, a Biomarker Discovery for Delirium project described in this application. Receipt of the K24 will enable me to more effectively leverage these studies and other ongoing work to support the work of trainees, who will in turn expand my research program. 2. To build a mentorship program that will expand POR in aging at BIDMC and HMS, with a focus on delirium and related conditions. This objective will be accomplished through structured, individual mentorship of young investigators with a strong interest in POR. Protected time for mentorship will be provided by the K24 award. 3. To expand my mentorship program to include translational, interdisciplinary work around biomarker discovery for delirium, and biomarker applications to improve risk stratification, diagnosis, and prognostication of older adults with delirium. This objective will be accomplished through my new research project, career development activities, and interdisciplinary collaborations that will be facilitated by receipt of the K24 award. My objectives will be greatly facilitated by the superb academic environment and outstanding institutional support provided by HMS and the BIDMC Divisions of General Medicine and Gerontology.