Bridging Sustainable Distribution of TRBD Bioinformatics Resources

《炎症与宿主对损伤的反应》是美国国家普通医学科学研究所(NIGMS)的大型合作项目奖之一。这些奖项通常被称为胶助金计划，其声明的目的是“使生物医学研究中的重大问题得以解决，并促进综合生物医学科学的下一个进化阶段”。我们的Glue Grant研究人员一致认为，在损伤研究领域需要解决的最重要的生物学问题集中在固有的炎症反应上，具体地说，是提高我们的系统水平，了解关键的调控元素，以及它们推动宿主对严重损伤及其伴随的严重全身炎症做出反应的相对作用和重要性。这个问题只能通过首先以发现驱动的方法获取大量新数据来解决。与我们在临床医学中引入高通量基因组学相关的启动成本在时间、精力和资金方面都是巨大的。对于我们的调查人员来说，一个重要的战略是通过与其他联邦资助机构、行业和/或其他非营利性组织的资助合作，维持在胶水赠款中开发的基础设施、资源、工具和方法。Funding Opportunity PAR-10-261允许我们寻求财政支持，以保持我们独特的数据集的可用性，使其成为“尚未自我维持的”资源，并提高我们所拥有的可视化工具的可用性 创建用于存储、组织、存档、分析和可视化由我们的程序生成的数据。有三个具体目标定义了维护和加强我们现有的生物信息学数据库和工具的活动。(1)优化Glue Grant计划期间部署和投产的TRDB信息系统。(2)通过改善数据库、模型、算法和可视化工具之间的链接，增强用户友好的Web界面环境。(3)优化异质数据集的显示，以实现不同损伤类型、细胞/组织类型、时间点采样和时间进程之间的首个同类比较分析。

"Inflammation and the Host Response to Injury" is one of the Large-Scale Collaborative Project Awards of the National Institute of General Medical Sciences (NIGMS). Commonly known as the Glue Grants program, the stated purpose of these awards was "to enable the solution of major problems in biomedical research and to facilitate the next evolutionary stage of integrative biomedical science". Our Glue Grant investigators agreed that the most important biological problem to tackle in the area of injury research centered on the innate inflammatory response, and specifically, to improve our systems level understanding of the key regulatory elements, and their relative roles and importance that drive the host's response to serious injury and its accompanying severe systemic inflammation. The problem could only be addressed by first acquiring large amounts of new data in a discovery-driven approach. The start-up costs associated with our introduction of high throughput genomics in clinical medicine in terms of time, effort, and money have been substantial. An important strategy for our investigators is to sustain the infrastructure, resources, tools, and methodologies developed in this Glue Grant through funding collaborations with other federal funding agencies, industry, and/or other nonprofit organizations. Funding opportunity PAR-10-261 allows us to seek financial support to preserve the availability of our unique datasets as resources "not yet self-sustaining" and to improve the usability of the visualization tools we have created to store, organize, archive, analyze, and visualize the data generated by our program. There are three specific aims that define the activities for maintaining and enhancing our existing bioinformatics databases and tools. (1) Optimize the TRDB information system deployed and in production during the Glue Grant program. (2) Enhance the user-friendly web interface environment by improving the linkage between databases, models, algorithms, and visualization tools. (3) Optimize the display of the heterogeneous datasets, to allow the first-of-its-kind comparative analyses between differing injury types, cell/tissue types, time point sampling, and time course.