Cardiovascular Disease Epidemiology in Medicaid Patients with Lupus
狼疮医疗补助患者的心血管疾病流行病学
基本信息
- 批准号:8678326
- 负责人:
- 金额:$ 17.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-05-15 至 2019-04-30
- 项目状态:已结题
- 来源:
- 关键词:Academic TrainingAddressAffectAgeAreaAutoimmune DiseasesBiostatistical MethodsCardiacCardiovascular DiseasesCaringCause of DeathClinicalClinical InvestigatorCohort StudiesCollaborationsCoronary Artery BypassCountryDataDevelopmentDiseaseDisease OutcomeEducational process of instructingEnrollmentEnvironmentEpidemiologic MethodsEpidemiologyEthnic OriginEventFeedbackFellowshipFutureGeneral PopulationGrantHealth InsuranceHealthcareHeart failureHospitalsHydroxychloroquineInflammatoryInterventionInvestigationKidneyKnowledgeLupusLupus NephritisMedicaidMedicalMentorsMethotrexateMorbidity - disease rateMyocardial InfarctionOperative Surgical ProceduresOutcomeOutcomes ResearchPatientsPeripheral Vascular DiseasesPharmaceutical PreparationsPharmacoepidemiologyPoliciesPopulationPositioning AttributePostdoctoral FellowProceduresPublic HealthPublic Health SchoolsRaceRecruitment ActivityRelative (related person)Relative RisksReportingResearchResearch PersonnelResearch Project GrantsResearch TrainingResourcesRheumatismRheumatoid ArthritisRheumatologyRiskSocioeconomic StatusStrokeSubgroupSystemic Lupus ErythematosusTeaching HospitalsTestingThrombosisTimeTrainingTraining ProgramsTumor Necrosis Factor-alphaUncertain RiskVariantVulnerable PopulationsWomanWorkadverse outcomebasecardiovascular disorder riskcareercohorthigh riskimprovedlecturesmedical schoolsmortalitynext generationpatient orientedpatient oriented researchpercutaneous coronary interventionpopulation basedpre-doctoralprogramspublic health relevanceresearch studysexsuccessyoung woman
项目摘要
DESCRIPTION (provided by applicant): Since completing her rheumatology fellowship and research training, Dr. Costenbader has devoted her career to patient-oriented rheumatic disease research. She has served as primary or secondary research mentor for 33 pre- and post-doctoral trainees. Along with her position as Co-Director of the Brigham and Women's Hospital Lupus Center, Dr. Costenbader's mentoring is facilitated by her affiliations with several Harvard teaching and training programs. Moreover, the candidate's multiple ongoing patient-oriented research projects and collaborations, commitment to mentoring, and exceptional institutional resources provide an outstanding environment for the development of junior investigators in patient-oriented rheumatic disease research. This K24 grant would preserve Dr. Costenbader's protected time and relieve future clinical and administrative responsibilities. The new research aims proposed will build upon past work in a large, nationwide lupus population with Medicaid data from 2000-2010. With data on over 66,000 lupus patients in the U.S., these studies will address key unanswered questions about cardiovascular disease risks, medical and surgical care, and outcomes. These important questions include whether cardiovascular disease risks are changing over time in this population, how post-cardiac event and intervention risks compare to those of the general population, whether lupus patients receive optimal cardiac care, and whether hydroxychloroquine reduces cardiovascular disease risks. The inherent sociodemographic variation and high medical risk of this vulnerable population make these studies extremely relevant for ongoing policy discussions about improving healthcare and outcomes. The findings of these powerful studies will inform future . Moreover, the proposed research studies will provide excellent mentoring opportunities. Dr. Costenbader will continue to recruit two to three new trainees into her rheumatic disease epidemiology and outcomes research program each year, and to expand and refine her formal mentoring program using feedback received from trainees, medical care and prescribing practices and seminars and lectures at the Brigham and Women's Hospital and Harvard Medical School. Based on institutional commitment and resources and Dr. Costenbader's successful record in research and mentoring, this K24 grant would greatly augment her ability to expand her existing research mentoring program and to develop the next generation of patient-oriented rheumatic disease investigators.
描述(由申请人提供):自从完成风湿病学奖学金和研究培训后,Costenbader博士致力于以患者为导向的风湿病研究。先后担任了33名在读前后博士生的一级或二级研究导师。除了担任布里格姆妇女医院狼疮中心的联合主任外,她还参与了哈佛大学的几个教学和培训项目,为她提供指导。此外,候选人的多个正在进行的面向患者的研究项目和合作,对指导的承诺,以及特殊的机构资源,为面向患者的风湿病研究的初级研究者的发展提供了良好的环境。这笔K24拨款将保留科斯滕巴德博士的受保护时间,并减轻未来的临床和行政责任。提出的新研究目标将建立在过去对2000-2010年全国范围内大量狼疮患者的研究基础上。这些研究收集了美国66,000多名狼疮患者的数据,将解决有关心血管疾病风险、医疗和手术护理以及结果的关键问题。这些重要的问题包括:在这一人群中,心血管疾病风险是否随着时间的推移而改变;与一般人群相比,心脏事件和干预风险如何;狼疮患者是否接受了最佳的心脏护理;羟氯喹是否降低了心血管疾病风险。这些弱势群体固有的社会人口差异和高医疗风险使得这些研究与正在进行的关于改善医疗保健和结果的政策讨论非常相关。这些强有力的研究结果将为未来提供信息。此外,拟议的研究将提供良好的指导机会。Costenbader博士每年将继续为她的风湿病流行病学和结果研究项目招募两到三名新学员,并利用从学员、医疗保健和处方实践以及布莱根妇女医院和哈佛医学院的研讨会和讲座中收到的反馈,扩大和完善她的正式指导计划。基于机构承诺和资源以及Costenbader博士在研究和指导方面的成功记录,K24资助将极大地增强她扩展现有研究指导计划的能力,并培养下一代以患者为导向的风湿病研究人员。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Karen H Costenbader其他文献
The Exposome: What Is It, Really, and Does it Help to Understand Environmental Influences on Human Health and Rheumatic Disease?
暴露组:它到底是什么?它有助于了解环境对人类健康和风湿病的影响吗?
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:13.3
- 作者:
Christine G Parks;Karen H Costenbader - 通讯作者:
Karen H Costenbader
Safety of CAR T-cell therapy for cancer in pre-existing autoimmune or inflammatory disease: a retrospective comparative cohort study
嵌合抗原受体(CAR)T细胞疗法用于存在自身免疫性或炎症性疾病患者癌症治疗的安全性:一项回顾性对比队列研究
- DOI:
10.1016/s2665-9913(24)00402-8 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:16.400
- 作者:
Kathleen M M Vanni;Kaitlin R McCarter;Xiaosong Wang;Caitlyn Duffy;Jamie P Dela Cruz;Holly Wobma;Sarah Nikiforow;Elena M Massarotti;Karen H Costenbader;Jessica S Little;Ellen M Gravallese;Gregory C McDermott;Caron A Jacobson;Jeffrey A Sparks - 通讯作者:
Jeffrey A Sparks
Prevalence and demographics of systemic lupus erythematosus and lupus nephritis among US children with Medicaid coverage, 2002-2004
- DOI:
10.1186/1546-0096-10-s1-a104 - 发表时间:
2012-07-13 - 期刊:
- 影响因子:2.300
- 作者:
Linda T Hiraki;Tamara Shaykevich;Wolfgang C Winkelmayer;Karen H Costenbader - 通讯作者:
Karen H Costenbader
Karen H Costenbader的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Karen H Costenbader', 18)}}的其他基金
Elucidating Social Determinants and Mental Health Needs to Achieve Equity in Rheumatic Disease Care
阐明社会决定因素和心理健康需求以实现风湿病护理的公平
- 批准号:
10797766 - 财政年份:2023
- 资助金额:
$ 17.59万 - 项目类别:
Sociodemographic Disparities in SLE Incidence: Behavioral and Psychosocial Factors
SLE 发病率的社会人口统计学差异:行为和社会心理因素
- 批准号:
9378558 - 财政年份:2017
- 资助金额:
$ 17.59万 - 项目类别:
Cardiovascular Disease Epidemiology in Medicaid Patients with Lupus
狼疮医疗补助患者的心血管疾病流行病学
- 批准号:
9071295 - 财政年份:2014
- 资助金额:
$ 17.59万 - 项目类别:
Cardiovascular Disease Epidemiology in Medicaid Patients with Lupus
狼疮医疗补助患者的心血管疾病流行病学
- 批准号:
9260809 - 财政年份:2014
- 资助金额:
$ 17.59万 - 项目类别:
Cardiovascular Disease Epidemiology in Patients with Lupus
狼疮患者的心血管疾病流行病学
- 批准号:
10192658 - 财政年份:2014
- 资助金额:
$ 17.59万 - 项目类别:
Cardiovascular Disease Epidemiology in Patients with Lupus
狼疮患者的心血管疾病流行病学
- 批准号:
9882953 - 财政年份:2014
- 资助金额:
$ 17.59万 - 项目类别:
Cardiovascular Disease Epidemiology in Patients with Lupus
狼疮患者的心血管疾病流行病学
- 批准号:
10394201 - 财政年份:2014
- 资助金额:
$ 17.59万 - 项目类别:
Cardiovascular Disease Epidemiology in Patients with Lupus
狼疮患者的心血管疾病流行病学
- 批准号:
10612756 - 财政年份:2014
- 资助金额:
$ 17.59万 - 项目类别:
Novel Biomarkers and Causal Pathways in RA Susceptbility
RA 易感性的新生物标志物和因果途径
- 批准号:
8457143 - 财政年份:2010
- 资助金额:
$ 17.59万 - 项目类别:
Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
维生素 D 和鱼油治疗自身免疫性疾病、炎症和关节疼痛
- 批准号:
7861111 - 财政年份:2010
- 资助金额:
$ 17.59万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 17.59万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 17.59万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 17.59万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 17.59万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 17.59万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 17.59万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 17.59万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 17.59万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 17.59万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 17.59万 - 项目类别:
Research Grant