Interactions Between Hedgehog and Ras Signaling in Lung Adenocarcinoma

Hedgehog 和 Ras 信号在肺腺癌中的相互作用

• 批准号: nhmrc : 546098
• 负责人: Prof David Watkins
• 金额: $ 19.74万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interactions-hedgehog-ras-lung-adenocarcinoma/96412
• 关键词: Interactions; Between; Hedgehog; Ras; Signaling

Lung cancer is a common and lethal disease in our community. In this project, we explore how signaling pathways that regulate the development of the lung in embryos contribute to the initation and progression of lung cancer. To do this, we use a mouse model of lung cancer in which we can activate embryonic signaling pathways in adult mice to study there effect on the disease. Understanding these pathways will help us to better treat and prevent lung cancer in humans.

肺癌是一种常见和致命的疾病在我们的社会。在这个项目中，我们探讨了调节胚胎肺发育的信号通路如何促进肺癌的发生和发展。为了做到这一点，我们使用了一个小鼠肺癌模型，在这个模型中，我们可以激活成年小鼠的胚胎信号通路来研究它们对疾病的影响。了解这些途径将有助于我们更好地治疗和预防人类肺癌。