Nutrition Education for Cardiovascular Disease Prevention in Individuals with Spi

描述（由申请人提供）：该K奖的目标是提供发展支持，使Jesse Lieberman博士成为慢性脊髓损伤（SCI）患者心血管疾病（CVD）预防领域的独立研究者。与健康对照组相比，慢性SCI患者的心血管疾病危险因素（如血脂异常、糖尿病和向心性肥胖）患病率增加。随后，与一般人群相比，CVD在该人群中更普遍且过早发生。这项研究的标题是“营养教育对脊髓损伤患者心血管疾病预防的作用：一项随机对照试验。“目的是探讨在急性康复期间进行额外的营养教育对营养知识的影响， 急性SCI患者一年内的饮食质量、体重状况和代谢性CVD风险。这项建议是高度创新的，因为在急性康复期间没有研究额外的营养教育，而且在SCI人群中进行的CVD预防研究很少。这项研究具有公共卫生意义，因为沿着每年约有12，000例创伤性SCI和数千例非创伤性SCI，估计有1，275，000名美国人患有SCI，而且与普通人群相比，SCI人群中CVD、肥胖和糖尿病的患病率增加。拟议的研究经验和相关的职业发展计划将为Lieberman博士提供多学科研究方面的培训，这对于解决慢性SCI人群中的CVD等复杂问题至关重要。该奖项的职业发展方面包括：强大的，多学科的指导;营养，赠款写作， 道德;参加国家会议和讲习班;指导营养研究经验;营养期刊文章评论;以及领导能力课程。候选人完全有资格受益于拟议的职业发展计划。他已经证明了一个重大的承诺，研究事业和大量的生产力通过工作支持的NHLBI研究补充，以促进多样性在健康相关的研究，和其他研究资助他的机构和其他来源。他将与他的导师和咨询委员会密切合作，在五年的拟议奖励，以实现所需的能力，成为一个独立的调查支持R 01资金和/或VA的优点审查。申请人至少有75%的时间将完全致力于本提案中的研究和职业发展计划。这一建议的意义涉及SCI人群的庞大规模，CVD在这一人群中的巨大负担，以及通过营养生活方式行为改变进行预防的潜力。这项研究的结果有可能对SCI患者的护理和结果产生显著的积极影响。此外，开发的研究能力将使利伯曼博士通过未来的研究努力产生重大影响。(End摘要）

DESCRIPTION (provided by applicant): The goal of this K Award is to provide developmental support that will allow Dr. Jesse Lieberman to become an independent investigator in the area of cardiovascular disease (CVD) prevention for individuals with chronic spinal cord injury (SCI). Individuals with chronic SCI are known to have an increased prevalence of CVD risk factors such as dyslipidemia, diabetes, and central obesity compared to matched, able-bodied controls. Subsequently, CVD is more prevalent and occurs prematurely in this population compared to the general population. The study is entitled "Nutrition education for cardiovascular disease prevention in individuals with spinal cord injury: A randomized controlled trial." The purpose is t investigate the effect of additional nutrition education during acute rehab on nutrition knowledge, diet quality, weight status, and metabolic CVD risk over the course of one year among persons with acute SCI. This proposal is highly innovative because additional nutrition education has not been studied during acute rehab, and very little CVD prevention research has been conducted in the SCI population. This study has public health significance because there are approximately 12,000 traumatic SCI/year along with several thousand non-traumatic SCI/year and an estimated 1,275,000 Americans living with a SCI, and because of the increased prevalence of CVD, obesity and diabetes in the SCI population compared to the general population. The proposed research experiences and the associated career development plan will provide Dr. Lieberman with training in multidisciplinary research that is essential to address a complex problem such as CVD in the chronic SCI population. The career development aspect of this award includes: strong, multidisciplinary mentorship; graduate courses in nutrition, grant writing, and ethics; attending national conferences and workshops; mentored nutrition research experience; nutrition journal article reviews; and a leadership course. The candidate is well qualified to benefit from the proposed career development plan. He has demonstrated a significant commitment to a research career and substantial productivity through work supported by an NHLBI Research Supplement to Promote Diversity in Health Related Research, and other studies funded by his institution and other sources. He will work closely with his mentors and advisory committee during the five years of the proposed award to achieve the competencies needed to become an independent investigator supported by R01 funding and/or VA merit review. At least 75% of the applicant's time will be fully committed and dedicated to the research and career development plan in this proposal. The significance of this proposal relates to the large size of the SCI population, the considerable burden of CVD in this population, and the potential for prevention through nutritional lifestyle behavior change. The results of this researc have the potential to make a significant positive effect on the care and outcomes of individuals with SCI. Furthermore, the research competencies developed will enable Dr. Lieberman to make substantial impact through future research endeavors. (End of Abstract)