ELECTROPHYSIOLOGY - TUSM/T-NEMC CENTER FOR NEUROSCIENCE RESEARCH

电生理学 - TUSM/T-NEMC 神经科学研究中心

• 批准号: 8787523
• 负责人: F Rob JACKSON
• 金额: $ 3.63万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8787523
• 关键词: Adopted; Automobile Driving; Behavior; Behavioral; Cells; Communities; Data; Educational workshop; Electrodes; Electrophysiology (science); Equipment; Evolution; Faculty; Funding; Future; Goals; Gold; Growth; Human Resources; Image; In Vitro; Investments; Laboratories; Methods; Mission; Mosses; Neurosciences; Neurosciences Research; Physiology; Research Personnel; Research Project Grants; Slice; Students; Techniques; Tissues; Training; Translational Research; Ursidae Family; demographics; in vivo; meetings; new technology; optogenetics; programs; research study; success; voltage clamp

Electrophysiological data are often considered the gold standard for demonstrating a causal relationship between cell/circuit physiology and behavior. Generating preliminary data is a daunting prospect, however, for an investigator who lacks the years of training necessary to produce a competent, independent electrophysiologist. Electrophysiological studies also require a considerable up-front investment in personnel and equipment, further discouraging investigators from entering the electrophysiological arena. When the EBC was first established, the electrophysiology community at Tufts was small (Cox and Dunlap being the only electrophysiologists on the faculty), yet there were significant numbers of faculty seeking to bring electrophysiological approaches to bear on their research projects. The EBC was, thus, established to promote more widespread use of electrophysiology in neuroscience research laboratories at Tufts. This mission has been realized more completely than we thought possible (see C5.2.3i for details). Tufts' electrophysiology community has changed dramatically since the CNR was established in 2003, in part due to the success of the EBC. Several investigators received their introduction to electrophysiology in the EBC. Remarkably, four of these (Feig, Galper, Jacob, Rios) now have students and/or fellows in their labs who independently perform such experiments on setups in their own labs or in the EBC. In addition, the recent Neuroscience Department expansion has further changed the demographics of CNR users. Electrophysiological recording is now key in the labs of Cox, Dunlap, Dulla, Feig, Galper, Haydon, Jacob, Maguire, Moss, Rios, and Trimmer. With this growth of the electrophysiology community, (i) the number of users needing access to EBC's existing setups is approaching a steady-state, (ii) the majority of EBC users are sufficiently trained to not only carry out their experiments independently, but to help train future lab personnel, and (iii) there is increasing demand for in vivo stimulation/recording as programs adopt a more behavioral focus. This evolution is driving changes in the EBC (described below) to allow us to continue to meet the electrophysiological needs of the Tufts neuroscience community.

电生理学数据通常被认为是证明细胞/电路生理学和行为之间因果关系的黄金标准。然而，对于一个缺乏培养合格的、独立的电生理学家所必需的多年培训的研究者来说，产生初步数据是一个令人望而生畏的前景。电生理研究还需要大量的前期人力和设备投入，这进一步阻碍了研究者进入电生理领域。当EBC成立之初，塔夫茨大学的电生理学界还很小（考克斯和邓拉普是教职员工中仅有的两名电生理学家），但有相当多的教职员工试图将电生理方法应用到他们的研究项目中。因此，EBC的建立是为了促进电生理学在塔夫茨大学神经科学研究实验室的更广泛应用。这个任务的实现比我们想象的要彻底（详见C5.2.3i）。